Chemotherapy with mitoxantrone and prednisone provides palliation for some patients with symptomatic hormone-resistant prostate cancer.

These results demonstrate that the addition of high doses of tamoxifen to this chemotherapy regimen does not increase the response rate compared with chemotherapy alone in unselected patients with metastatic melanoma.

No abstract

SUMMARY1. The energy expenditure of normal and congenitally obese adult female Zucker rats has been measured by continuous indirect calorimetry for periods of 3-10 days at ambient temperatures varied from 30 to 5 'C. Rectal temperatures were also recorded.2. Exposure to cold caused no ill-effects in normal or obese rats. 3. The rectal temperatures ofobese rats were about 1 'C lower than those ofnormal rats. The rectal temperatures of normal rats did not change measurably with ambient temperature; in obese rats rectal temperature rose slightly as ambient temperature fell.4. In normal and obese rats, energy expenditure showed a smooth, steeply sloping, negative relationship to ambient temperature. Energy expenditure per rat was higher in obese than in normal rats at all temperatures. The two slightly curvilinear regressions were nearly 'parallel', with a separation of about 40 kJ/day per rat at the mid-point.5. This study therefore does not confirm suggestions that obese Zucker rats suffer from a defect in the level of energy expenditure, or in their capacity to increase it when exposed to cold.

The addition of CMF to TAM adds no benefit and considerable toxicity in this group of women.