Intracolonic injection of glycerol: A model for abdominal pain in irritable bowel syndrome?

Impaired Proximal Colonic Motor Response to Rectal Mechanical and Chemical Stimulation in Obstructed Defecation

“…28 The effect of rectal chemical stimulation on the motor activity of the terminal ileum and proximal colon is not as well described, although chemical stimulation to the rectum has been shown to enhance colonic activity. 35,36 The major findings in patients with OD in the present study were that they lack the normal inhibitory rectoileal and rectocolonic response to rectal mechanical distention and they lack of a normal increase in proximal colonic PSs in response to rectal chemical stimulation. 17 As these patients are capable of generating a normal daily frequency of colonic propagating pressure wave sequences (PS), 4 the neuronal apparatus necessary to produce this motor pattern must be intact.…”

Motility in Irritable-Bowel Syndrome

“…The colonic motor response to psychologic stress was found to be both similar to and higher than in control subjects [10,16]. Instillation of glycerol was reported to stimulate colonic motility and to induce pain in IBS patients [17], Psycho logic stress was found to increase contractile activity in IBS patients only [10].…”

Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

“…Injection of glycerol into the rectum inhibits tone in the left colon. 21 In healthy subjects, voluntary suppression of defaecation for 1 week significantly delays gastric emptying. 22 Stimulation of digestive afferent pathways triggers also secretory responses, like release of epinephrine by adrenal glands or of opiate peptides in the ENS.…”

“…20 On the contrary, the stimulation or the distension of a caudad segment results in an inhibition of the more proximal gut segment. Hence, intrarectal injection of glycerol inhibits colonic tone by a reflex recation 21 and in healthy subjects, voluntary suppression of defaecation results in a delay of gastric emptying. 22 Disturbed viscero-visceral reflexes might be triggered by exaggerated sensory influxes and result in abnormal motor responses.…”