Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

Delvaux, Michel

doi:10.1016/j.bpg.2004.06.004

Cited by 26 publications

(14 citation statements)

References 128 publications

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“…Organic and functional disorders of the GI tract are associated with abdominal pain thought to be due to alterations in visceral sensitivity. Individuals with IBS report discomfort in response intraluminal intestinal pressure at physiological levels and elevated discomfort at supraphysiological pressures 30,31 . Abdominal pain is a common symptom of active IBD, but studies of visceral sensitivity in these individuals have been limited to evaluation of individuals in remission.…”

Section: Discussionmentioning

confidence: 99%

“…As the animal recovered, the opposite end of the tubing was attached to a modifiable barostatic device (Bioengineering, University of Iowa, Iowa City, IA, USA). After full recovery from the anaesthesia (30 min), the balloon was inflated to a given pressure (15,30,45 and 60 mmHg) for 20 s. 16 The 10-s inflations were repeated four times for each pressure level, with rest periods of 5 min following each inflation. During each inflation period, external oblique muscle EMG activity was filtered, amplified and recorded as described in previous reports.…”

Section: Measuring the Visceromotor Response To Colorectal Distensionmentioning

confidence: 99%

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Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse

Coates

Johnson

Meerveld

et al. 2006

Neurogastroenterology Motil

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Serotonin-selective reuptake transporter (SERT) expression is decreased in animal models of intestinal inflammation and in individuals with inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS), and it is possible that resultant changes in intestinal serotonin signalling contribute to the manifestation of clinical features associated with these disorders. The objective of this investigation was to determine whether inhibition of SERT function leads to changes in gut motility and sensitivity. Mice underwent a 14-day treatment with the SERT inhibitor, paroxetine (20 mg kg(-1)), or vehicle (saline/propylene glycol). Gastrointestinal (GI) transit following charcoal gavage, colonic motility, stool frequency and visceromotor responses to colorectal distension were evaluated. In mice treated with paroxetine, stool output was decreased, upper GI transit was delayed, and colonic sensitivity to a nociceptive stimulus was attenuated. These results demonstrate that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Measuring the Visceromotor Response To Colorectal Distensionmentioning

confidence: 99%

Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse

Coates

Johnson

Meerveld

et al. 2006

Neurogastroenterology Motil

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“…The threshold for discomfort or pain lower than MDP ϩ 32 mmHg was used in this study to define visceral hypersensitivity (3,17). The threshold for discomfort or pain lower than MDP ϩ 32 mmHg was used in this study to define visceral hypersensitivity (3,17).…”

Section: Rectal Barostat Testmentioning

confidence: 99%

SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine

Kerckhoffs

Linde

Akkermans

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

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Colorectal visceral hypersensitivity has been demonstrated in a subset of irritable bowel syndrome (IBS) patients. Serine protease and serotonergic signaling modulate gastrointestinal visceral sensitivity. We evaluated whether altered mucosal serine protease and serotonergic pathway components are related to rectal visceral hypersensitivity in IBS patients. Colorectal mucosal biopsies of 23 IBS patients and 15 controls were collected. Gene transcripts of protease-activated receptor (PAR)-2, trypsinogen IV, tryptophan hydroxylase (TPH)-1, and serotonin reuptake transporter (SERT) were quantified using real-time polymerase chain reaction. Substance P and 5-HT contents were measured by ELISA. The number of enterochromaffin cells, mast cells, and intraepithelial lymphocytes was determined using immunohistochemistry. Rectal visceral sensitivity was determined in IBS patients using barostat programmed for phasic ascending distension. Rectal hypersensitivity (+) and (−) IBS patients showed lower TPH-1 and SERT mRNA levels in the rectum compared with controls ( P ≤ 0.05). Rectal hypersensitivity (+) IBS patients ( n = 12) showed lower TPH-1 mRNA level in the sigmoid compared with controls ( P = 0.015). No significant differences were observed in PAR-2 and trypsinogen IV expression between controls and IBS patients. Rectal substance P content was increased in IBS patients compared with controls ( P = 0.045). No significant differences were found in transcript levels, cell counts, and substance P and 5-HT contents between rectal hypersensitivity (+) and (−) IBS patients. In conclusion, regardless of visceral hypersensitivity state, several serotonergic signaling components are altered in IBS patients.

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“…8 It must also be pointed out that visceral pain and altered gut motility may depend upon altered motility reflexes resulting from increased sensitivity of the digestive tract. 9 Taken together, all these data provide rationale for the usefulness of antispasmodic agents in the short-term treatment of acute painful episodes. Phloroglucinol (P) and its methylated derivative (TMP) are both antispasmodic agents acting on smooth muscle and devoted to treat abdominal pain.…”

Section: Introductionmentioning

confidence: 95%

Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol – a randomized, double‐blind, placebo‐controlled study

Chassany

Bonaz

Varannes

et al. 2007

Aliment Pharmacol Ther

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Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

Cited by 26 publications

References 128 publications

Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse

Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse

SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine

Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol – a randomized, double‐blind, placebo‐controlled study

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