Motility in Irritable-Bowel Syndrome

Müller-Lissner, S; Coremans, Georges; Dapoigny, Michel; Pace, F.; Smout, Andreas J.; Stockbrügger, R.W.; Tougas, Gervais; Whorwell, Peter J.; Wienbeck, M

doi:10.1159/000201444

Cited by 8 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although motor abnormalities of the large bowel have been described in both conditions [3, 4, 5, 6], especially for IBS, unequivocal data have not been reported consistently. Recent evidence, however, seems to suggest that an abnormal colonic motility may actually be documented in IBS patients [7, 8, 9, 10].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Colonic Propagated Activity in Patients with Slow Transit Constipation and Constipation-Predominant Irritable Bowel Syndrome

Bassotti

Chistolini²,

Marinozzi³

et al. 2003

Digestion

View full text Add to dashboard Cite

Background: The pathophysiological basis of constipation is still unclear, and the role of colonic dysfunction is debated, especially in irritable bowel syndrome. Objective data are quite scarce, especially concerning colonic propulsive activity. Aims: To evaluate high- and low-amplitude colonic propulsive activity in constipated patients (slow-transit type and irritable bowel syndrome) in comparison with normal controls. Patients and Methods: Forty-five constipated patients (35 with slow-transit constipation and 10 with constipation-predominant irritable bowel syndrome) were recruited, and their data compared to those of 18 healthy subjects. Twenty-four-hour colonic manometric recordings were obtained in the three groups of subjects, and data concerning high- and low-amplitude colonic propulsive activity were then compared. Results: High-amplitude propagated contractions were significantly (p < 0.05) decreased in patients with slow-transit constipation and constipation-predominant irritable bowel syndrome with respect to controls (1.5 ± 0.4, 3.7 ± 2, and 6 ± 1 events/subject/day, respectively). In slow-transit constipation, a significant decrease of contractions’ amplitude was also observed. Concerning low-amplitude propagated contractions, patients with slow-transit constipation had significantly less events with respect to patients with constipation-predominant irritable bowel syndrome (46 ± 7 vs. 87.4 ± 19, p = 0.015); no differences were found between patients with slow-transit constipation and controls and between patients with constipation-predominant irritable bowel syndrome and controls. All three groups displayed a significant increase of low-amplitude propagated contractions after meals (6.3 ± 2 vs. 18.2 ± 5 for controls, p < 0.005; 6.4 ± 1.4 vs. 16.3 ± 2.4 for slow-transit constipation, p < 0.005; 10.5 ± 3.2 vs. 32.6 ± 7 for constipation-predominant irritable bowel syndrome, p = 0.001). Conclusions: Low-amplitude propagated contractions may represent an important physiologic motor event in constipated patients, reducing the severity of constipation in patients with irritable bowel syndrome and preserving a residual colonic propulsive activity in patients with slow-transit constipation.

show abstract

Section: Introductionmentioning

confidence: 99%

Abnormal Colonic Propagated Activity in Patients with Slow Transit Constipation and Constipation-Predominant Irritable Bowel Syndrome

Bassotti

Chistolini²,

Marinozzi³

et al. 2003

Digestion

View full text Add to dashboard Cite

show abstract

“…Although a clear relationship between changes in motility and visceral hypersensitivity in IBS patients has not yet been established (Muller-Lissner et al 1997), the smooth muscle relaxant properties of otilonium bromide are thought to underlie its beneficial effect on symptoms of IBS patients (Battaglia et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon

Santicioli

Zagorodnyuk

Renzetti

et al. 1999

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

We have analyzed, by the sucrose gap method, the action of otilonium bromide, a quaternary ammonium derivative in use for the symptomatic therapy of irritable bowel syndrome, on the electrical and mechanical responses initiated by different stimuli in the circular muscle of the guinea-pig proximal colon. Otilonium bromide produced a concentration-dependent inhibition of membrane depolarization (IC50 4.1 microM), action potentials (APs) and contraction (IC50 3.7 microM) produced by the muscarinic receptor agonist, methacholine. It also produced a concentration-dependent inhibition of APs and accompanying contraction (IC50 31 microM) produced by KCl (30 mM), and had a biphasic effect on the cholinergic excitatory junction potential (e.j.p.) produced by single pulse electrical field stimulation: at low concentrations (0.1-0.3 microM) otilonium bromide enhanced the e.j.p. and, at higher concentrations (IC50 22 microM and 16 microM toward depolarization and contraction), produced a concentration-dependent inhibition. Otilonium bromide eliminated the APs superimposed on the depolarization induced by the tachykinin NK1 receptor agonist, [Sar9]substance P-sulphone and suppressed the corresponding contraction (IC50 43 microM) but had little effect on the sustained membrane depolarization induced by this agonist. On the other hand, otilonium bromide produced a similar inhibitory effect on both membrane depolarization and contraction (IC50 38 microM and 45 microM, respectively) induced by the tachykinin NK2 receptor agonist [betaAla8]neurokinin A (4-10). When tested in the presence of nifedipine (1 microM), otilonium bromide had no effect on the membrane depolarization induced by [Sar9]substance P-sulphone but inhibited in a concentration-dependent manner the depolarization induced by [betaAla8]neurokinin A (4-10) (IC50 41 microM). In contrast, the blocker of receptor-operated cation channels, SKF 96365, inhibited with similar potency the depolarization induced by both [Sar9]substance P-sulphone and [betaAla8]neurokinin A (4-10) (IC50 60 microM and 54 microM, respectively). In radioligand binding experiments otilonium bromide produced a concentration-dependent inhibition of the binding of both an agonist ([125I]neurokinin A, Ki 7.2 microM) and an antagonist ([3H]SR 48968, Ki 2.2 microM) to membranes of Chinese hamster ovary cells transfected with the human tachykinin NK2 receptor. In conclusion, the present findings demonstrate that, in the microM range of concentrations, otilonium bromide acts as a muscarinic and tachykinin NK2 receptor antagonist and as a calcium channel blocker. The latter property is likely to account for its ability to suppress contraction initiated by the tachykinin NK1 receptor agonist. Therefore multiple mechanisms of action account for the ability of otilonium bromide to reduce stimulated motility of intestinal smooth muscle.

show abstract

“…Eine internationale Expertengruppe fasste 1997 nach mehreren Konferenzen den bisherigen Stand der Forschung in einem Bericht zusammen [37]. Demnach scheinen Veränderungen der gastrointestinalen Motilität tatsächlich häufiger bei Reizdarmpatienten aufzutreten, diese werden jedoch weder als spezifisch für die Erkrankung angesehen, noch korrelieren sie mit den typischen Beschwerden der Patienten.…”

Section: Introductionunclassified

“…Demnach scheinen Veränderungen der gastrointestinalen Motilität tatsächlich häufiger bei Reizdarmpatienten aufzutreten, diese werden jedoch weder als spezifisch für die Erkrankung angesehen, noch korrelieren sie mit den typischen Beschwerden der Patienten. Aus diesem Grunde werden systematische Motilitätsaufzeichnungen auch nicht mehr als integraler Bestandteil der klinischen Diagnostik empfohlen [37].…”

Section: Introductionunclassified

See 1 more Smart Citation

Psychophysiologie des Eingeweideschmerzes

Musial

2002

Der Schmerz

View full text Add to dashboard Cite

This paper reviews the most important research strategies in the context of the psychophysiology of visceral pain. These are disturbed gastrointestinal motility, visceral hypersensitivity and central nervous system mechanisms such as response bias, attentional bias and affective evaluation. The most prominent research methods and results are reviewed and methodological problems are discussed. From a psychophysiological perspective, visceral pain remains a complex and heterogeneous syndrome in which stress and coping may be etiologically as important as pathophysiological mechanisms of peripheral origin and central nervous system mechanisms like attentional bias.

show abstract

Motility in Irritable-Bowel Syndrome

Cited by 8 publications

References 33 publications

Abnormal Colonic Propagated Activity in Patients with Slow Transit Constipation and Constipation-Predominant Irritable Bowel Syndrome

Abnormal Colonic Propagated Activity in Patients with Slow Transit Constipation and Constipation-Predominant Irritable Bowel Syndrome

Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon

Psychophysiologie des Eingeweideschmerzes

Contact Info

Product

Resources

About