Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats

Niaz, Nasir; Güvenç, Gökçen; Altınbaş, Burçin; Toker, Mehmed Berk; Aydın, Begüm; Udum-Kucuksen, Duygu; Alçay, Selim; Gökçe, Elif; Üstüner, Burcu; Yalçın, Murat

doi:10.1016/j.brainres.2018.08.020

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…In male rats, the administration of histamine dose and time dependently increased plasma hormones (GnRH, FSH, LH) and testosterone levels (Niaz et al, 2018).…”

Section: Introductionmentioning

confidence: 94%

Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Alazzouni

Aziz

El‐Nabtity

et al. 2020

JoBAZ

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Background Peptic ulcer is an excoriated area of stomach or intestinal mucosa. Two experimental designs were proceeded: the first aimed. on twenty adult male albino rats, used to study the protective effect of both ranitidine and nizatidine; on the second, including sixty adult male albino rats, was used to study the therapeutic effect of ranitidine and nizatidine after induction of ulcer and also to evaluate the adverse effects of therapeutic doses of H2-receptor antagonists on male hormonal profile. The study aims to assess the gastroprotective effects of nizatidine and ranitidine and on treating of non-steroidal anti-inflammatory drugs (NSAIDs) induced peptic ulcer and to evaluate its adverse effect on male sex hormones. Result The result revealed that ranitidine and nizatidine reduced incidence of ulceration. Histopathological findings showed a significant recovery of the alteration, and disturbance in male sex hormones. Conclusion Nizatidine is better than ranitidine in the management of NSAIDs induced peptic ulcer in rats.

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“…In male rats, the administration of histamine dose and time dependently increased plasma hormones (GnRH, FSH, LH) and testosterone levels (Niaz et al, 2018).…”

Section: Introductionmentioning

confidence: 94%

Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Alazzouni

Aziz

El‐Nabtity

et al. 2020

JoBAZ

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“…The hypothalamic-pituitary-gonadal (HPG) axis can adjust the body's fertility (Kaprara & Huhtaniemi, 2018), and is the key regulatory axis of testicular function (Niaz et al, 2018). T is the most abundant steroid androgen in men that are tightly regulated by the HPG axis (Shea, Wong, & Chen, 2014).…”

Section: Discussionmentioning

confidence: 99%

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Zhou

Wei

et al. 2020

J. Food Biochem.

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In addition to being nutritional elements, proteins in food can also regulate the body's physiological functions, which is achieved via specific peptide sequences in the proteins (Chakrabarti, Guha, & Majumder, 2018). Therefore, although many bioactive peptides are stored in dietary proteins, the peptides remain inactive in the protein sequence and only have specific physiological functions after being released (Kitts & Weiler, 2003). Proteases from various sources can release biologically active peptides (Korhonen & Pihlanto, 2006), which are absorbed by the body via a different absorption route than the protein (Silk, Grimble, & Rees, 1985). Bioactive peptides can be absorbed directly from the intestine into the bloodstream, where they are highly active, exhibiting physiological effects in small amounts. The bioactive peptide activity is controlled by the composition and sequence of amino acids (Chakrabarti et al., 2018), and many peptides are known to reveal multifunctional properties

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“…Çalışmada kullanılan histamin ve reseptör antagonistleri daha önceki çalışmamızda kullandığımız etkin dozlardan seçilmiştir (21).…”

Section: Deneysel Protokolunclassified

Merkezi Yolla Enjekte Edilen Histamin ve Reseptör Antagonistlerinin, Sıçanların Yem, Su Alımı ve Vücut Ağırlıkları Üzerine Etkileri

Altınbaş¹,

Bayram²,

Yalçın³

2021

Turkish Journal of Diabetes and Obesity

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Aim: The histaminergic system, which has a wide distribution in the central nervous system, especially the hypothalamus, plays a role as a neurotransmitter or neuromodulator in the regulation of many autonomic functions. In the hypothalamus, histamine receptors are widely distributed in many nuclei involved in the regulation of food, water intake and body weight. In this study, food and water intake and body weight changes caused by histamine, chlorpheniramine, ranitidine and thioperamide treatments chronically in rats were investigated. Material and Methods:The study was carried out in Sprague-Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), histaminergic H2 receptor antagonist ranitidine (100 nmol), or histaminergic H3/H4 receptor antagonist thioperamide (100 nmol) were injected via the cerebral side ventricular route for 7 days. The data were analyzed with the IBM SPSS Effects of Centrally Injected Histamine and Receptor Antagonists on Feed, Water Intake and Body Weight of Rats ÖZ Amaç: Başta hipotalamus olmak üzere merkezi sinir sisteminde geniş bir dağılım gösteren histamin birçok otonomik işlevin düzenlenmesinde bir nörotransmitter veya nöromodülatör olarak rol almaktadır. Hipotalamusta; yiyecek, su alımı ve vücut ağırlığının düzenlenmesinde görev alan birçok çekirdekte histamin reseptörleri geniş bir dağılıma sahiptir. Çalışmada, merkezi yolla histamin, klorfeniramin, ranitidin ve tiyoperamid tedavilerinin sıçanlarda oluşturduğu yiyecek ve su alımı ile vücut ağırlığı değişimleri araştırılmıştır. Gereç ve Yöntemler: Çalışma, Sprague-Dawley ırkı sıçanlarda gerçekleştirilmiştir. Histamin (100 nmol), histaminerjik H1 reseptör antagonisti klorfeniramin (100 nmol), histaminerjik H2 reseptör antagonisti ranitidin (100 nmol) veya histaminerjik H3/H4 reseptör antagonisti tiyoperamid (100 nmol) serebral yan ventriküler yolla günde bir kez olacak şekilde 7 gün boyunca enjekte edilmiştir. Veriler IBM SPSS Statistics (v23) paket programı ile analiz edilmiştir. Verilerin analizinde, Kolmogorov-Smirnov Testi, ANOVA ve Dunnet testleri kullanılmıştır. p<0,05 istatistiksel olarak anlamlı sayılmıştır.Bulgular: Histamin, klorfeniramin ve ranitidinin gıda ve su alımı ile vücut ağırlığında azalmalara neden olmuştur (p<0,05). Fakat tiyoperamid ile yapılan tedavi bahsedilen ilaçların tersine gıda ve su alımı ile vücut ağırlığında artışlara yol açmıştır (p<0,05).Sonuç: Elde edilen veriler, 7 günlük tedaviler sonrasında merkezi histamin, klorfeniramin ve ranitidin tedavilerinin beslenmenin düzenlenmesinde negatif etkilere yol açtığını göstermektedir. Bunun yanında, merkezi tiyoperamid ile yapılan 7 günlük tedavinin gıda ve su alımı ile kilo alımına neden olduğu ortaya çıkmıştır.

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Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats

Cited by 12 publications

References 33 publications

Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Merkezi Yolla Enjekte Edilen Histamin ve Reseptör Antagonistlerinin, Sıçanların Yem, Su Alımı ve Vücut Ağırlıkları Üzerine Etkileri

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