Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones

Abstract

Background Peptic ulcer is an excoriated area of stomach or intestinal mucosa. Two experimental designs were proceeded: the first aimed. on twenty adult male albino rats, used to study the protective effect of both ranitidine and nizatidine; on the second, including sixty adult male albino rats, was used to study the therapeutic effect of ranitidine and nizatidine after induction of ulcer and also to evaluate the adverse effects of therapeutic doses of H2-receptor antagonists on male hormonal profile. The study aims to assess the gastroprotective effects of nizatidine and ranitidine and on treating of non-steroidal anti-inflammatory drugs (NSAIDs) induced peptic ulcer and to evaluate its adverse effect on male sex hormones. Result The result revealed that ranitidine and nizatidine reduced incidence of ulceration. Histopathological findings showed a significant recovery of the alteration, and disturbance in male sex hormones. Conclusion Nizatidine is better than ranitidine in the management of NSAIDs induced peptic ulcer in rats.

Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin®-induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways

“…Furthermore, the histopathological and immunohistochemical findings supported the previous results and agreed with Alazzouni et al ( 2020 ). On the surfaces of endothelial cells, Aspirin® may stimulate the expression of cell adhesion molecules, damage to the stomach mucosa and the recruitment of leukocytes to inflammatory areas.…”

Role of carbon nanotubes in remediation of pharmaceutical wastewater

“…Table 2 also summarizes the health hazards posed by the presence of different compounds present in pharmaceutical wastewater. Antibiotics contribute to antibiotic‐resistant bacteria proliferation, hormones and endocrine‐disrupting compounds disrupt hormonal and reproductive function in both wildlife and humans, pain relievers and psychiatric medications can adversely affect aquatic life, cytostatic drugs can be toxic, heavy metals can accumulate and harm organisms, personal care product chemicals (e.g., phthalates and parabens) may have endocrine‐disrupting properties, and residual solvents used in pharmaceutical manufacturing can exhibit toxicity (Ahmed et al, 2011; Alazzouni et al, 2020; Currie, 2023; Elnashar et al, 2024; Farag & Bahra, 2022; Khezri et al, 2020; Kuczyńska & Nieradko‐Iwanicka, 2021; Li et al, 2023; McCormick et al, 2008). Hence, it is essential to treat pharmaceutical wastewater effectively to remove or minimize these compounds before discharge to safeguard the environment and human health.…”