Intracerebral Plasma Cell Tumor in a Cat: A Case Report and Literature Review

Greenberg, Marc J.; Schatzberg, Scott J.; deLahunta, A; Stokol, Tracy; Summers, B. A.

doi:10.1892/0891-6640(2004)18<581:ipctia>2.0.co;2

Cited by 12 publications

(11 citation statements)

References 18 publications

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“…More serious manifestations, especially in cats, involve the eyes (ophthalmomyiasis; Johnson et al, 1988;Harris et al, 2000;Wyman et al, 2005;Stiles and Rankin, 2006), respiratory system (nasal/pharyngeal/tracheal myiasis; Thirloway, 1982;Fitzgerald et al, 1996;Dvorak et al, 2000), or central nervous system (cerebrospinal myiasis; Cook et al, 1985;Hendrix et al, 1989;Glass et al, 1998;King, 2000). In these cases, clinical signs and symptoms can include anorexia, lethargy, inflammation, retinal damage, impaired vision, dyspnea, seizures, paralysis, or a combination, and definitive diagnoses can be difficult (many of the above references; also see Greenberg et al, 2004). Treatments for these conditions are often experimental and of uncertain efficacy, and the outcome may be fatal, either because the animal dies outright or is killed.…”

Section: Buchymentioning

confidence: 99%

Parasitic Helminths of Free-Ranging Mink (Neovison vison mink) From Southern Florida

Foster¹,

Cunningham

Kinsella³

et al. 2007

Journal of Parasitology

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Five free-ranging mink, Neovison vison mink, from in or near the Fakahatchee Strand Preserve State Park, Collier County, Florida (26 degrees 00'N, 81 degrees 25'W), were examined for parasitic helminths. Nine species of helminths were identified (2 trematodes, 5 nematodes, and 2 acanthocephalans). The most prevalent parasites were Molineus patens (4 of 5 mink), mean intensity 173 (range, 12-342); Strongyloides sp. (4 of 5), mean intensity 48 (range, 1-170); Macracanthorhynchus ingens (immature) (4 of 5), mean intensity 2.5 (range, 1-4); and Alaria mustelae (3 of 5), mean intensity 59.3 (range, 11-127). Polymorphus brevis and Dirofilaria lutrae are reported from the mink for the first time.

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Section: Buchymentioning

confidence: 99%

Parasitic Helminths of Free-Ranging Mink (Neovison vison mink) From Southern Florida

Foster¹,

Cunningham

Kinsella³

et al. 2007

Journal of Parasitology

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“…32,39,59 Many histopathologic reports of feline MRD simply describe myeloma cells as plasma cells. However, other terminology has been used: ''plasmacytoid cells'' have been reported in single cases of plasmacytoma, 9,24,43 and ''lympho-plasmacytoid'' appearance was described in 2 cases reported as lymphoma (IgSL) 62,77 and 1 case reported as multiple myeloma. 20 Small to medium-sized lymphocytes were described in 1 case of IgSL.…”

Section: Introductionmentioning

confidence: 99%

Histopathologic, Immunohistochemical, and Cytologic Analysis of Feline Myeloma-Related Disorders: Further Evidence for Primary Extramedullary Development in the Cat

et al. 2008

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Abstract. Feline myeloma-related disorders (MRD) are rare neoplasms of plasma cells. The multistep transformation model of myeloma in humans is based on the premise that plasma cells undergo neoplastic transformation primarily within the intramedullary compartment and that over time they become poorly differentiated and metastasize to extramedullary locations. Historically, diagnostic criteria used for human multiple myeloma have been applied to the cat, with the assumption that feline MRD commonly arises in the intramedullary compartment. Our objectives were to describe the features of feline MRD confirmed by cytology, histopathology, histochemistry, and immunohistochemistry and to categorize these tumors. A priori hypotheses were 1) tumor category predicts survival and 2) cats with well-differentiated tumors commonly have extramedullary involvement in contrast to human myeloma patients. This multicenter, retrospective study identified 26 MRD cases. There was good agreement between histopathologic and cytologic tumor categorization. Histochemistry and immunohistochemistry were shown to be valuable adjunct tests in the diagnosis of MRD. Cats with well-differentiated tumors had increased median survival relative to those with poorly differentiated tumors (254 versus 14 days). We have reported that marked extramedullary involvement at initial clinical presentation is significantly more common in the cat than in human MRD patients. In this study, we demonstrate that cats with welldifferentiated tumors more commonly have extramedullary involvement than human myeloma patients with well-differentiated tumors (90% versus 20%, P , 0.0002). These results contrast strongly with the human myeloma model of primary intramedullary neoplastic transformation and suggest that primary extramedullary neoplastic transformation may be more common in feline MRD.

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“…14-29 to 14-32) (Seo et al, 2011). Other round cell tumors (Greenberg et al, 2004;Sheppard et al, 1997;Stowe et al, 2012;Tzipory et al, 2009) are less common and include encephalic and spinal plasma cell tumors (Fig. 14-31A&B).…”

Section: Neural Cystic and Neoplastic Lesion Findings In Cerebrospinamentioning

confidence: 99%

The Central Nervous System

Lorenzi¹,

Mandara²

2016

Canine and Feline Cytology

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Intracerebral Plasma Cell Tumor in a Cat: A Case Report and Literature Review

Cited by 12 publications

References 18 publications

Parasitic Helminths of Free-Ranging Mink (Neovison vison mink) From Southern Florida

Parasitic Helminths of Free-Ranging Mink (Neovison vison mink) From Southern Florida

Histopathologic, Immunohistochemical, and Cytologic Analysis of Feline Myeloma-Related Disorders: Further Evidence for Primary Extramedullary Development in the Cat

The Central Nervous System

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