Prednisone/cytosine arabinoside is a safe empirical therapy for dogs with meningoencephalitis of unknown aetiology; this drug combination may prolong survival time.
Intravascular lymphoma (malignant angioendotheliomatosis, angiotrophic lymphoma) is a rare neoplastic disorder in dogs. The literature contains few reports in dogs and a single report in a cat. Intravascular lymphoma is characterized by an intravascular proliferation of malignant lymphocytes. This unique angiocentric distribution of neoplastic cells leads to the characteristic clinicopathologic feature of thromboses and infarctions. In people, intravascular lymphoma has a predilection for vessels in the central nervous system (CNS) and skin. Typically, affected patients have episodic symptoms that coincide with the timing of infarctions. This report details the clinicopathologic description and magnetic resonance (MR) images of a dog with intravascular lymphoma that resulted in multiple CNS infarctions. Abnormalities identified with MR imaging consisted of multifocal hyperintensities observed in pre-contrast T1-weighted, T2-weighted, intermediate-weighted, and FLAIR pulse sequences. Lesions were most conspicuous on the FLAIR images. In addition, there was mild enhancement of the lesions seen in post-contrast T1 weighted images.
An eight-year-old, female spayed, domestic shorthair cat presented with a three-week history of progressive general proprioceptive ataxia and upper motor neuron paresis of the hindlimbs. Computed tomography revealed a mediastinal mass invading the vertebral canal with the T1 spinal nerve and roots, causing extramedullary compression of the cranial thoracic spinal cord. Histopathological and immunohistochemical studies of the mass during postmortem examination disclosed a neoplasm, later determined to be a poorly differentiated histiocytic sarcoma. Feline histiocytic tumours are rare, with only two prior reports existing in the veterinary literature. This report details a case work-up and reviews the literature on feline histiocytic diseases and tumours affecting the feline spinal
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