Intracellular plasma proteins in human fetal choroid plexus during development II. The distribution of prealbumin, albumin, alpha-fetoprotein, transferrin, IgG, IgA, IgM, and alpha1-antitrypsin

Transthyretin distribution in the developing choroid plexus of the South American opossum ( Monodelphis domestica )

“…The difference could be due to the difference in tissue fixation and preservation, as human material was obtained from abortions whereas tissue used in the present study was perfusedfixed immediately after killing the animal. In the human fetus, transthyretin was observed in more than 90% of the choroidal epithelial cells examined (Jacobsen et al 1982), and in this study similar proportions (90-95%) of transthyretin-positive cells were found. In the rat embryo transthyretin mRNA was located in the epithelial cells of the choroid plexus primordia, appearing first in the fourth ventricle, followed by the lateral ventricle and subsequently the third ventricle (Thomas et al 1988).…”

“…In the human, transthyretin immunoreactive products were described as dispersed throughout the cytoplasm with occasional perinuclear rarefaction in the choroidal epithelial cells (Aleshire et al 1983) or distributed evenly in the whole apical region of the cytoplasm (Møllgård et al 1979;Jacobsen et al 1982). In the opossum, however, almost all transthyretin-immunoreactive products were concentrated as granules in a small region of the cytoplasm apical to the nucleus.…”

“…Additionally, transthyretin was found in the epithelial cells of fetal, neonatal, and adult human choroid plexus by immunocytochemical staining (Møllgård et al 1979;Jacobsen et al 1982;Aleshire et al 1983). However, no detailed studies of the distribution of transthyretin immunoreactivity in the different choroid plexuses during development have been performed.…”

“Amyloid Is Not a Tombstone”— A Summation

“…A strong antibody reaction to prealbumin was found in the choroid epithelial cells of AD patients irrespective of age or the occurrence of amyloid. However, there was no correlation between amyloid in the choroid plexus and Alzheimer's disease 109 . Jacobsson et al and others 110,111 found prealbumin in up to 90% of the cells in the choroid plexus as compared to only 40% of cells showing albumin, transferrin.…”

Interpretation of alpha-fetoprotein concentrations in cerebrospinal fluid of infants

“…3,4 AFP is also known to exist in the epithelial cells of the human fetal choroid plexus but declines in concentration in these cells as gestation progresses. 5 In fetal serum, AFP reaches a peak concentration of about 2,500,000 kIU/L by the ¢fteenth week of pregnancy and decreases thereafter, in part due to the rapid increase in fetal size. AFP concentrations range from a mean of approximately 40,000 kIU/L at birth to normal adult levels by about 8 months of age.…”