Transthyretin distribution in the developing choroid plexus of the South American opossum ( Monodelphis domestica )

Li, Z. S.; Dzięgielewska, Katarzyna M.; Saunders, NR

doi:10.1007/s004410050785

Cited by 7 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies, using immunocytochemistry, showed that a number of common plasma proteins (albumin, fetuin, ␣-fetoprotein, transthyretin, and transferrin) are found in epithelial cells of immature choroid plexuses at all three sites at which choroid plexuses are found, IIIrd, IVth, and lateral ventricles. The quantitative studies of Jacobsen et al (1982aJacobsen et al ( ,b, 1983, Knott et al (1997), and Li et al (1997) confirmed the semi-quantitative impression that positive cells are much more frequent in immature choroid plexuses and that staining is absent in choroid plexuses of the more mature brain, with the exception of transthyretin. Transthyretin distribution also differs from other plasma proteins in that it is present in almost all choroid plexus epithelial cells at all ages, whereas other plasma proteins are only present in a small proportion of the cells.…”

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 73%

“…The only other systematic cytochemical investigations of the developing choroid plexuses appear to be our studies, carried out mainly in collaboration with Møllgård and colleagues on the distribution of plasma proteins in the human fetus (Jacobsen et al, 1982a,b;Møllgård et al, 1979a) and in fetal sheep (Jacobsen et al, 1983) and our more recent studies of choroid plexus in postnatal Monodelphis domestica (Knott et al, 1997;Li et al 1997). These studies, using immunocytochemistry, showed that a number of common plasma proteins (albumin, fetuin, ␣-fetoprotein, transthyretin, and transferrin) are found in epithelial cells of immature choroid plexuses at all three sites at which choroid plexuses are found, IIIrd, IVth, and lateral ventricles.…”

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 99%

“…Transthyretin distribution also differs from other plasma proteins in that it is present in almost all choroid plexus epithelial cells at all ages, whereas other plasma proteins are only present in a small proportion of the cells. Li et al (1997) have shown that albumin and transthyretin are co-localised in epithelial cells of the developing choroid plexus, at least in Monodelphis. The origin of transthyretin in choroid plexus has been shown to be from in situ synthesis (see article by Schreiber, Richardson and Prapunpoj, pages 21-30, this issue).…”

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 99%

See 2 more Smart Citations

Development of the choroid plexus

Dziegielewska

Habgood

et al. 2001

Microsc. Res. Tech.

View full text Add to dashboard Cite

Mammalian choroid plexuses develop at four sites in the roof of the neural tube shortly after its closure, in the order IVth, lateral, and IIIrd ventricles. Bone morphogenetic proteins and tropomyosin are involved in early specification of these sites and in early plexus growth. Four stages of lateral ventricular plexus development have been defined, based on human and sheep fetuses; these depend mainly on the appearance of epithelial cells and presence or absence of glycogen. Other plexuses and other species are probably similar, although marsupials may lack glycogen. Choroid plexuses form one of the blood-brain barrier interfaces that control the brain's internal environment. The mechanisms involved combine a structural diffusion restraint (tight junctions between the plexus epithelial cells) and specific exchange mechanisms. In this review, it is argued that barrier mechanisms in the developing brain are different in important respects from those in the adult brain, but these differences do not necessarily reflect immaturity of the system. Absence of a barrier mechanism or presence of one not found in the adult may be a specialisation that is appropriate for that stage of brain development. Emphasis is placed on determining which mechanisms are present in the immature brain and relating them to brain development. One mechanism unique to the developing brain transfers specific proteins from blood to cerebrospinal fluid (CSF), via tubulocisternal endoplasmic reticulum in plexus epithelial cells. This results in a high concentration of proteins in early CSF. These proteins do not penetrate into brain extracellular space because of "strap" junctions between adjacent neuroependymal cells, which disappear later in development, when the protein concentration in CSF is much lower. Functions of the proteins in early CSF are discussed in terms of generation of a "colloid" osmotic pressure that expands the ventricular system as the brain grows; the proteins may also act as specific carriers and growth factors in their own right. The pathway for low molecular weight compounds, which is much more permeable in the developing choroid plexuses, appears also to be a transcellular one, rather than paracellular via tight junctions. There is thus good evidence to support a novel view of the state of development and functional significance of barrier mechanisms in the immature brain. It grows in an environment that is different from that of the rest of the fetus/neonate and that is also different in some respects from that of the adult. But these differences reflect developmental specialisation rather than immaturity.

show abstract

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 73%

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 99%

Section: Morphological Development Of the Choroid Plexus Light Microsmentioning

confidence: 99%

See 1 more Smart Citation

Development of the choroid plexus

Dziegielewska

Habgood

et al. 2001

Microsc. Res. Tech.

View full text Add to dashboard Cite

show abstract

“…Synthesis of transthyretin by the choroid plexus has only been studied in one American marsupial species: the short‐tailed grey opossum ( Monodelphis domestica) . Synthesis of transthyretin by the choroid plexus was detected during development from the day of birth [81] and in the adult [79].…”

Section: Sites Of Transthyretin Synthesis Throughout Vertebrate Evolumentioning

confidence: 99%

Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis

Richardson

2009

The FEBS Journal

View full text Add to dashboard Cite

Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins. Of particular interest is transthyretin, which in mammals is synthesized in the liver, choroid plexus, meninges, retinal and ciliary pigment epithelia, visceral yolk sac, placenta, pancreas and intestines, whereas the other thyroid hormone distributor proteins are synthesized only in the liver. Transthyretin is synthesized by all classes of vertebrates; however, the tissue specificity of transthyretin gene expression varies widely between classes. This review summarizes what is currently known about the evolution of transthyretin synthesis in vertebrates and presents hypotheses regarding tissue‐specific synthesis of transthyretin in each vertebrate class.

show abstract

“…However, CP has not been described in the central canal of the spinal cord and thus any possible role not only in the aetiology of recurrent syringomyelia but also in spinal cord development has yet to be addressed. Furthermore, CP may mediate effects of peripheral inflammation in the nervous system by altering gene expression profile after an inflammatory stimulus 14 . On the other hand, systemic non-inflammatory disease may enhance an inflammatory reaction in CP as seen in an autopsy of the CP of two patients treated for diabetic ketoacidosis 15 .…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Choroid Plexus in the Central Canal of the Spinal Cord Causing Recurrent Syringomyelia

et al. 2018

View full text Add to dashboard Cite

Our illustrative case reveals the presence of CP in the central canal of the spinal cord that may suggest a role in the etiology of recurrent syringomyelia. Although management poses a challenge to neurosurgeons, prompt decompression and shunting of the syringomyelia remains a favorable approach with acceptable outcomes. Further investigation into the pathophysiology of central canal CP ectopic causing recurrent syringomyelia and its correlation with spinal cord development may help future treatments.

show abstract

Transthyretin distribution in the developing choroid plexus of the South American opossum ( Monodelphis domestica )

Cited by 7 publications

References 16 publications

Development of the choroid plexus

Development of the choroid plexus

Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis

Choroid Plexus in the Central Canal of the Spinal Cord Causing Recurrent Syringomyelia

Contact Info

Product

Resources

About