Intracellular free calcium content plays a role in low magnesium-induced increases in prostacyclin production

Zhou, Qi; Kummerow, Fred A.

doi:10.1684/mrh.2012.0306

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…A similar situation was observed for Ca 2+ [20]. Moreover, Mg 2+ strongly interacts with Ca 2+ and K + , the deficiency-excess of one cation influencing the effects of the others [5,12,22,26]. A large part of the population is confronting stress, sleeping disorders and chronic fatigue.…”

Section: Introductionsupporting

confidence: 56%

Influence of Magnesium Compounds on Sodium, Potassium and Calcium Levels in Different Mice Organs

Moisa¹

2019

FARMACIA

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The administration of Mg 2+ determines not only the increase of Mg 2+ , but also induces changes in the tissular levels of Ca 2+ , K + and Na + . The effects of dietary Mg 2+ on macro-elements (Ca 2+ , K + , Na + ) levels in mice tissues (heart, liver, spleen, kidney and lung) were investigated in a murine study. Doses of 300, 200, 100, 50 and 25 mg of different Mg compounds (orotate, sulphate, oxide, chloride, carbonate, citrate) were administrated by gavage. The results showed that Na + and K + levels increase, while Ca 2+ levels decrease with the increase of the Mg 2+ level. In all organs, macro-elements levels decrease in the following order: K + > Na + > Ca 2+ . The highest intracellular Na + , K + and Ca 2+ levels were obtained in the case of Mg-orotate administration, while no significant changes in the intracellular Na + , K + and Ca 2+ levels were obtained by Mg supplementation as oxide, citrate or carbonate. The principal component analysis confirmed that the increase of intracellular Na + is accompanied by the increase of intracellular K + and vice versa. Also, high intracellular Ca 2+ levels are expected at low Mg 2+ doses. RezumatAdministrarea de Mg 2+ determină nu numai o creștere a conținutului de Mg 2+ , ci și modificări ale nivelurilor de Ca 2+ , K + și Na + în țesuturi. În această lucrare s-a studiat influența compușilor cu Mg 2+ asupra macro-elementelor (Ca 2+ , K + , Na + ) în țesuturile (inimă, ficat, splină, rinichi și plămâni) de șoareci. Au fost administrate doze de 300, 200, 100, 50 și 25 mg de diferiți compuși de Mg (orotat, sulfat, oxid, clorură, carbonat, citrat) prin gavaj. Rezultatele indică o creștere a nivelurilor de Na + și K + , în timp ce nivelul de Ca 2+ scade odată cu creșterea nivelului de Mg 2+ . În toate organele, nivelul de macro-elemente scade în următoarea ordine: K + > Na + > Ca 2+ . Cele mai mari niveluri intracelulare de Na + , K + și Ca 2+ au fost obținute în cazul administrării de orotat de Mg, în timp ce, ca urmare a administrării de Mg 2+ sub formă de oxid, citrat sau carbonat, nu au fost observate schimbări semnificative în nivelul intracelular de Na + , K + și Ca 2+ . Analiza componentelor principale a confirmat creșterea K + intracelular odată cu creșterea Na + și vice-versa. De asemenea, concentrații ridicate de Ca 2+ intracelular apar la administrarea de doze mici de Mg 2+ .

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Section: Introductionsupporting

confidence: 56%

Influence of Magnesium Compounds on Sodium, Potassium and Calcium Levels in Different Mice Organs

Moisa¹

2019

FARMACIA

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“…More studies are required to understand whether Mg deficiency induces the synthesis of these lipids in HMEC. At the moment, only prostacyclins are known to be induced by exposure of endothelial cells to low Mg [32]. Recently, the serine/threonine phosphatase PPM1B [PP (protein phosphatase), Mg 2+ /Mn 2+ dependent, 1B] has emerged as a novel selective modulator of PPAR␥ activity [33].…”

Section: Discussionmentioning

confidence: 99%

Potential interplay between NFκB and PPARγ in human dermal microvascular endothelial cells cultured in low magnesium

Castiglioni¹,

Cazzaniga²,

Maier³

2014

Magnesium Research

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Dermal microvascular endothelial cells contribute to cutaneous inflammation by secreting proinflammatory cytokines and chemokines. We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. This secretory pattern might result from interplay between NFB, the master regulator of inflammation, and PPAR␥, a transcription factor that has emerged as an inhibitor of inflammation. Indeed, both NFB and PPAR␥ are activated in dermal microvascular endothelial cells cultured in low magnesiumcontaining medium. In conclusion, we hypothesize that PPAR␥ and NFB might contribute to the response of these cells to low Mg.

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“…Vascular endothelial cells play an important role in tumor invasion and metastasis . The major product of endothelial cell is PGI 2 , which is a strong vasodilator and the most powerful inhibitor of platelet aggregation . Studies have shown that the PGI 2 and PGI 2 analogs can exert an inhibitory effect on lymphogenous and hematogenous tumor metastasis .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

Dai

Tang

et al. 2019

J Biomed Mater Res

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Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms. In our study, when compared with pure Mg, the rare element silver alloyed with yttrium (Ag–Y) could extremely enhance the corrosion resistance of these elements, giving the Ex–Mg–1Ag–1Y alloy better anticorrosion rates. Here, we implanted the Ex–Mg–1Ag–1Y alloy and pure Mg and Ti alloy in vivo around tumors in nude mice (BALB/c). Notably, the local tumor weight in Mg alloy and pure Mg groups were much smaller than that in Ti alloy group in 36 days after surgery (6.59 ± 0.70, 6.76 ± 0.62, and 8.54 ± 0.56 g), while the general scores of lung metastasis in Mg alloy and pure Mg groups were also lower than Ti alloy group (64.50 ± 7.64, 62.73 ± 7.84, and 87.60 ± 9.43). Therefore, the Mg and Ex–Mg–1Ag–1Y alloy, both demonstrated resisting effects against local tumor growth and pulmonary metastasis, which could be performed by changing the extracellular acidosis microenvironment, elevating the Mg concentration, suppressing C–X–C chemokine receptor type 4 (CXCR4) levels, and increasing prostacyclin (PGI2) synthesis. Our work revealed that the Ex–Mg–1Ag–1Y alloy may be a promising orthopedic implant for treating osteosarcoma due to its better corrosion resistance and antitumor attributes. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2537–2548, 2019.

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Intracellular free calcium content plays a role in low magnesium-induced increases in prostacyclin production

Cited by 3 publications

References 44 publications

Influence of Magnesium Compounds on Sodium, Potassium and Calcium Levels in Different Mice Organs

Influence of Magnesium Compounds on Sodium, Potassium and Calcium Levels in Different Mice Organs

Potential interplay between NFκB and PPARγ in human dermal microvascular endothelial cells cultured in low magnesium

Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

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