Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

Dai, Yongnian; Tang, Yifu; Xu, Xuemei; Luo, Zhenguo; Zhang, Yu; Li, Zhaohui; Lin, Zhenghua; Zhao, Shushan; Zeng, Min; Sun, Buhua; Cheng, Liang; Zhu, Jianxi; Xiong, Zeng; Long, Haitao; Zhu, Yong; Yu, Kun

doi:10.1002/jbm.b.34344

Cited by 15 publications

(7 citation statements)

References 46 publications

(57 reference statements)

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“…Extrusion could refine the grain, which mainly decreased the degradation rate in the early stages. After immersion for a period of time, the degradation rate of the Mg-Ag alloys decreased more than that of pure Mg, resulting from the formation of a protective compact product layer [ 42 , 43 ]. Then, corrosive ions, such as Cl − , might penetrate the substrate, causing pits on the surface.…”

Section: Discussionmentioning

confidence: 99%

Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys In Vitro and In Vivo

Liu

Han²,

et al. 2022

Bioinorganic Chemistry and Applications

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Binary magnesium-silver (Mg-Ag) alloys were designed as antibacterial materials for biomedical implant applications. In the present study, we focused on the effects of extrusion (extrusion ratio (ER): 1, 7.1, and 72.2) and Ag content (Ag = 0, 3, and 6 wt.%) on the degradation of Mg-Ag alloys in vitro and in vivo via microstructure characterization and corrosion/degradation measurements. The results showed that the Ag promoted a galvanic reaction with the Mg matrix to accelerate degradation or formed a protective oxide mesh texture to inhibit degradation, especially in vivo. Ag might also be beneficial for product crystallization, biomineralization, and organic matter deposition. For pure Mg, extrusion produced a more refined grain and decreased the degradation rate. For the Mg-Ag alloys, a low extrusion ratio (7.1) accelerated the degradation caused by the increase in the proportion of the precipitate. This promoted the release of Mg2+ and Ag+, which led to more deposition of organic matter and calcium phosphate, but also more H2 bubbles, which led to disturbance of product deposition in some local positions or even inflammatory reactions. Extrusion at a higher ratio (72.2) dissolved the precipitates. This resulted in moderate degradation rates and less gas production, which promoted osteogenesis without an obvious inflammation reaction.

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Section: Discussionmentioning

confidence: 99%

Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys In Vitro and In Vivo

Liu

Han²,

et al. 2022

Bioinorganic Chemistry and Applications

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“…reported that Mg wires could suppress the growth of ovarian tumors and promote apoptosis [ 13 ]. Some studies have also revealed that Mg and its alloys exert excellent inhibitory effects on the proliferation and metastasis of OS [ 43 ]. Mei Li et al.…”

Section: Discussionmentioning

confidence: 99%

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

Wei

Tang

et al. 2021

Materials Today Bio

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The recurrence of osteosarcoma (OS) after reconstruction using Ti6Al4V prostheses remains a major problem in the surgical treatment of OS. Modification of the surfaces of Ti6Al4V prostheses with antitumor functions is an important strategy for improving therapeutic outcomes. Magnesium (Mg) coating has been shown to be multifunctional: it exhibits osteogenic and angiogenic properties and the potential to inhibit OS. In this study, we determined the proper concentration of released Mg 2+ with respect to OS inhibition and biosafety and evaluated the anti-OS effects of Mg-coated Ti6Al4V scaffolds. We found that the release of Mg 2+ during short-term and long-term degradation could significantly inhibit the proliferation and migration of HOS and 143B cells. Increased cell apoptosis and excessive autophagy were also observed, and further evidence of AMPK/mTOR/ULK1 signaling pathway activation was obtained both in vitro and in vivo , which suggested that the biofunctional scaffolds induce OS inhibition. Our study demonstrates the ability of an Mg coating to inhibit OS and may contribute to the further application of Mg-coated Ti6Al4V prostheses.

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“…In Mg–Y binary alloys, intermetallic compounds can accelerate micro-galvanic corrosion. In contrast, oxide films containing Y can enhance surface protection [ 210 , 211 , 212 , 213 ]. The presence of Dy in Mg–Dy alloys can lead to the formation of protective layers.…”

Section: Influential Factors For Corrosion Behavior In Magnesiummentioning

confidence: 99%

Corrosion Behavior in Magnesium-Based Alloys for Biomedical Applications

Liu

Sun

et al. 2022

Materials

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Magnesium alloys exhibit superior biocompatibility and biodegradability, which makes them an excellent candidate for artificial implants. However, these materials also suffer from lower corrosion resistance, which limits their clinical applicability. The corrosion mechanism of Mg alloys is complicated since the spontaneous occurrence is determined by means of loss of aspects, e.g., the basic feature of materials and various corrosive environments. As such, this study provides a review of the general degradation/precipitation process multifactorial corrosion behavior and proposes a reasonable method for modeling and preventing corrosion in metals. In addition, the composition design, the structural treatment, and the surface processing technique are involved as potential methods to control the degradation rate and improve the biological properties of Mg alloys. This systematic representation of corrosive mechanisms and the comprehensive discussion of various technologies for applications could lead to improved designs for Mg-based biomedical devices in the future.

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Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

Cited by 15 publications

References 46 publications

Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys In Vitro and In Vivo

Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys In Vitro and In Vivo

Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway

Corrosion Behavior in Magnesium-Based Alloys for Biomedical Applications

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