“…However, with the rapid development of industry and frequent anthropogenic pollution in the last decades, outbreaks of disease and ocean pollution have affected the pearl aquaculture industry, and lead to heavy economic losses. Pearl oyster has suffered serious disease caused mainly by bacteria (Lau et al, 2006), rickettsia-like organism (Wu and Pan, 1997), parasites (Hine and Thorne, 2000;Spiers et al, 2008) and virus (Suzuki et al, 1998;Kitamura et al, 2000Kitamura et al, , 2002, which could be related to the dramatic decline in South China seawater pearl production. In recent years, to control disease and enhance the yields and quality of seawater pearl, great effort has been done to understand the molecular mechanism of immune regulation of pearl oyster, and some immune-relevant factors have been identified and characterized from pearl oyster (Zhang et al, 2009a(Zhang et al, ,b,c, 2010.…”