Intrabulbar and peribulbar accumulation of dendritic OKT 6-positive cells in alopecia areata

Prevention of toxic epidermal necrolysis by regulatory T cells

“…For example, experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis induced by immunizing with myelin basic protein (MBP) [1]. Although the involvement of autoimmunity is suggested in many inflammatory skin diseases, obvious autoantigens have not been found in most cases [2][3][4]. We have established a transgenic mouse (K5-mOVA) expressing ovalbumin (OVA) under a control of human keratin 5 promoter as a model skin autoantigen.…”

Alopecia Areata-a Clinical Analysis

“…The inflammatory infiltrate is composed mainly of activated T lymphocytes, with a preponderance of CD4 cells, along with macrophages and Langerhans' cells. 21,22 Little or none of the inflammatory infiltrate is seen around the isthmus of the hair follicle, the site of hair follicle stem cells. 23 Follicles are smaller than normal and anagen follicles do not develop beyond the Anagen III-IV stage, when the hair shaft starts to be formed.…”

Immunohistochemical Study of Langerhans Cells in Skin Tumors

“…Both the monoclonal antibody OKT6 and antiserum for S-100 antigen are highly reliable and now widely used as histochemical markers [5,6]. The increase in number of LCs has been demonstrated in certain inflammatory or neoplastic conditions [3,7,8], However, few studies have been reported so far on the dis tribution of LCs in nonlymphomatous skin tumours [9,10], In the present paper, the be havior of LCs in various benign and malig nant skin tumors was investigated by means of immunohistochemical method using both OKT6 and anti-S-100 antibodies. …”

“…Langerhans cells (LCs) are the bonemarrow-derived immune cells in the epider mis and play an important role in cutaneous cell-mediated immune responses such as contact hypersensitivity [1,2], They are found not only in the epidermis but also in hair follicles, especially in the infundibular region [3,4], Since the identification of LCs is very difficult in routinely prepared histo logic sections, the detection of Birbeck gran ules by electron microscopy is required. However, the recent progress in immunolog ic techniques made possible the visualiza tion of LCs by antibodies recognizing specific determinants on the cell surface or within the cytoplasm of LCs.…”