Intima-Media Thickness of the Common Carotid Artery Is Not Significantly Higher in Crohn’s Disease Patients Compared to Healthy Population

Abstract

Crohn's disease patients do not have an increased risk for developing early atherosclerosis.

Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

“…Our data confirm the results of most studies conducted in Mediterranean area [27][28][29][30], though other studies, carried out in Israel obtained opposite results [22][23]. We could speculate that ethnicity might have an influence on the risk of atherogenesis, being higher in population from Italy and Turkey, as compared with population from Israel, even if, we do not have any genetic markers to support our hypothesis.…”

“…From a clinical point of view, the assessment of early atherosclerosis has been made by investigating surrogate markers such as the carotid artery intima-media thickness (IMT), flow-mediated vasodilatation of the brachial artery (FMD) and arterial stiffness by pulse wave velocity (PWV) [21][22][23][24][25][26][27][28][29][30]. The study by Aloi et coll, reported signs of endothelial dysfunction and early atherosclerosis even in children with IBD [27].…”

Reactive hyperaemia index as a marker of endothelial dysfunction in children with Crohn's disease is significantly lower than healthy controls

“…IMT increases gradually during childhood, and thus, the precise definition of cut‐off values remains difficult to set in this population . These facts correspond with conflicting results regarding IMT in children with IBD and with previously published studies in young adults . On the contrary, RHI measurement as a noninvasive plethysmographic method is technically easy to perform, and automatic analysis substantially reduces operator dependency.…”

Pulse Wave Velocity, Intima Media Thickness, and Flow-mediated Dilatation in Patients with Normotensive Normoglycemic Inflammatory Bowel Disease

“…Of 9 studies, 5 reported increased CIMT in patients with IBD compared with controls, 17 , 31 – 34 and 4 studies found no difference between IBD and controls. 13 , 27 , 35 , 36 Thus, these results showed that the available data regarding the association of IBD and CIMT still remains controversial, and that additional information is required. In this study, we did not find any difference regarding CIMT levels among subjects UC, CD, and healthy controls.…”