Pulse Wave Velocity, Intima Media Thickness, and Flow-mediated Dilatation in Patients with Normotensive Normoglycemic Inflammatory Bowel Disease

Öztürk, Kayhan; Güler, Ahmet; Çakır, Mehmet Volkan; Özen, Alptuğ; Demirci, Hakan; Türker, Türker; Demirbaş, Şeref; Uygun, Ahmet; Gülşen, Mustafa; Bağcı, Sait

doi:10.1097/mib.0000000000000355

Cited by 38 publications

(78 citation statements)

References 42 publications

(60 reference statements)

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“…The association between disease duration, a variable associated with chronic inflammation, and increased arterial stiffness in patients with UC is in accordance with previous data [11,12,28,29]; the association between acute inflammation and arterial stiffening has been previously reported in other models of inflammation [30]. Taken together, these findings suggest that, in contrast to physiological aging and accelerated aging reported in patients with CKD, in whom aortic, but not brachial stiffening was shown, in UC patients both elastic and muscular components of arterial tree could be affected by inflammation.…”

Section: Arterial Phenotype In Patients With Ucsupporting

confidence: 80%

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Zanoli

Lentini

Boutouyrie

et al. 2018

European Journal of Internal Medicine

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Section: Arterial Phenotype In Patients With Ucsupporting

confidence: 80%

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Zanoli

Lentini

Boutouyrie

et al. 2018

European Journal of Internal Medicine

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“…Ozturk et al found significant increase in PWV in a rather large sample but they were not able to evidentiate a difference in IMT [31]. In our study, we assessed arterial stiffness, not only by PWV, but also by central AIx.…”

Section: Discussionmentioning

confidence: 59%

“…Though being effective in the maintenance of remission of mild-to-moderate UC and possibly effective in chemoprevention, in other indications the role of 5-ASA is questioned and definitely not enough for the proper control of inflammation in Crohn's Disease. The effect of medications on vascular parameters has not been confirmed by Ozturk et al [31] though this could be explained by a more relevant proportion of UC patients in their cohort, thus on maintenance therapy with 5-ASA, which in UC could lead to an adequate control of inflammation.…”

Section: Discussionmentioning

confidence: 73%

“…Both studies showed that there was an increase in both carotid-radial and carotid-femoral PWV in IBD patients as compared with controls and that arterial stiffness of these patients was related to the degree of inflammation and reduced by immunomodulatory drugs. More recently, Ozturk et al [31] added further evidence to the association of early atherosclerosis markers and IBD by investigating arterial stiffness, FMD and IMT, showing a significant relationship between disease duration and hemodynamic parameters.…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

Cappello

Licata

Calvaruso

et al. 2017

European Journal of Internal Medicine

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Background & Aims:Recent studies documented an increased cardiovascular risk in patients with inflammatory bowel disease (IBD). Our study aimed at investigating the prevalence of intima-media thickness (IMT) of the carotid arteries and the arterial stiffness indices as markers of early atherosclerosis in young IBD patients. Methods: We recruited 68 consecutive IBD patients, and 38 matched healthy controls less than 45 years old (median age 31.6 ± 8.1 years). Clinical and demographic features, cardiovascular risk factors, history of cardiovascular events, concomitant therapies were registered on a dedicate database. Carotid IMT was evaluated by using high resolution B-mode ultrasonography. Arterial stiffness was assessed by measurement of carotidfemoral Pulse Wave Velocity (PWV) and Augmentation Index (AIx). Results: Total cholesterol (P b 0.013) and LDL-cholesterol (P b 0.019) levels were significantly lower in IBD patients compared to controls. Carotid IMT was higher in IBD than in controls (P b 0.047), but there was no statistically significant difference among Crohn's Disease (CD) and Ulcerative Colitis (UC) patients. Moreover, PWV and AIx were significantly higher in patients as compared to controls (P b 0.006 and P b 0.004 respectively). No medication seemed to affect vascular measurements, though stiffness parameters were significantly higher in patients treated with 5-ASA (11.9 (9.7) vs 18.2 (10.2), P b 0.021), suggesting a lack of efficacy of 5-ASA in protecting IBD patients from early atherogenesis. Conclusions: Young IBD patients show an increase in subclinical markers of atherosclerosis. Future studies need to address whether these markers result in an increased risk of cardiovascular events in these patient.

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“…For these abnormalities, noninvasive vascular parameters are used. Flow-mediated dilatation is used for endothelial dysfunction and carotid femoral pulse wave velocity as a marker of arterial stiffness [22]. CIMT is a vascular parameter of structural alterations in intima and media in early atherosclerosis [23].…”

Section: Discussionmentioning

confidence: 99%

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

2019

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Background: Ulcerative colitis (UC) is characterized by chronic relapsing-remitting inﬂammation of the gastrointestinal tract. The chronic inﬂammatory process may predispose to atherosclerosis. The aim of the study was to assess the carotid intima-media thickness (CIMT) and its relation to subclinical atherosclerosis and to follow up cardiovascular complications in patients with UC. Methods: 83 patients with proven UC in remission were enrolled in the study. 42 age- and sex-matched healthy controls were taken. Patients with known risk factors for atherosclerosis were excluded from the study. Baseline blood investigations along with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fasting lipid profile were done. CIMT was measured using B-mode Doppler imaging study. Results: The mean age of the UC patients was 37.06 ± 14.87 years. Left-sided colitis (45.8%) was the commonest type of presentation according to the extent of the disease. Mean CIMT (0.55 ± 0.17) was significantly higher in UC patients when compared to mean CIMT (0.46 ± 0.13) in the control group (p = 0.002). In Pearson correlation analysis, age, ESR, and CRP were positive and significantly correlated with CIMT. Multiple linear regression analysis (R² = 0.18, p = 0.0026) revealed that age and CRP were significant independent predictors of mean CIMT. On following up for 6 months, 4 patients with UC had complications in the form of venous thrombosis. Conclusion: CIMT is a simple, noninvasive, reliable and objective auxiliary vascular parameter of structural alteration in UC patients.

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Pulse Wave Velocity, Intima Media Thickness, and Flow-mediated Dilatation in Patients with Normotensive Normoglycemic Inflammatory Bowel Disease

Abstract: Article first published online 23 March 2015.

Cited by 38 publications

References 42 publications

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Pulse wave velocity differs between ulcerative colitis and chronic kidney disease

Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis

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