Intestinal taurine availability from synthetic amino acid-taurineconjugates: an in vitro perfusion study in rats

Hummel, Monika; Pogan, Karin; Stehle, Peter; Fürst, Peter

doi:10.1016/s0261-5614(97)80241-5

Cited by 10 publications

(3 citation statements)

References 9 publications

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“…The aim of the present study was to evaluate absorption and metabolism of cyanidin-3-glucoside in the presence and absence of ethanol by using an isolated rat small intestine (duodenum, jejunum and ileum) [13,14]. This organ perfusion model facilitates direct investigation of luminal disappearance and venous appearance of administered compounds, thereby allowing the estimation of intestinal absorption.…”

Section: Introductionmentioning

confidence: 99%

Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol

et al. 2003

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Anthocyanins are receiving renewed attention for their positive health attributes. High intakes and an adequate absorption rate of anthocyanins are necessary for efficient protection, though other dietary agents might influence absorption efficacy. The aim of this study was to investigate intestinal handling of luminally administered cyanidin-3-glucoside in the absence and presence of ethanol in an isolated preparation of luminally and vascularly perfused rat small intestine. A synthetic perfusate free from blood components was used as vascular medium, with a perfluorocarbon as the oxygen carrier. Luminal media consisted of a bicarbonate buffered sodium chloride solution in water or in water/ethanol (95/5), spiked with cyanidin-3-glucoside. Absorption rate of cyanidin-3-glucoside was 4.3% +/- 3.2 (n=5). Ethanol (5 %) had no significant influence on absorption rate (2.9% +/- 1.8, n=5). Irrespective of the presence of ethanol, the majority of the absorbed cyanidin-3-glucoside appeared unchanged, besides some cyanidin-3-glucoside-conjugate.

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Section: Introductionmentioning

confidence: 99%

Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol

et al. 2003

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“…While aglycones were absorbed from the rat stomach, absorption of genistin has not been observed. The aim of the present study was to evaluate absorption and metabolism of genistin by using an isolated rat small intestine (duodenum, jejunum and ileum) [12,13]. This organ perfusion model facilitates direct investigation of luminal disappearance and venous appearance of administered compounds, thereby allowing the estimation of intestinal absorption.…”

Section: Introductionmentioning

confidence: 99%

Absorption and metabolism of genistin in the isolated rat small intestine

2000

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Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 W Wmol/l. The intestinal absorption of genistin was 14.9% ( þ 2.3, n = 9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein. Sulfate derivatives of genistein or genistin were not observed. ß

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“…Hydrolase activities against these conjugates are considerably higher in rat mucosa and kidney homogenates than in plasma. 61,62 Additionally, in subcellular fractions of rat mucosa the hydrolase capacities of the brush border membrane vesicles and cytosol were at least 300-fold and 30-fold higher, respectively, than in plasma. The existence of considerable membrane-bound and intracellular hydrolase activity suggests that amino acid-taurine conjugates might be used as efficient sources of free taurine in clinical nutrition.…”

Section: Utilization Of Dipeptides: In Vitro Studiesmentioning

confidence: 94%

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

Fürst

2000

J Parenter Enteral Nutr

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Intestinal taurine availability from synthetic amino acid-taurineconjugates: an in vitro perfusion study in rats

Cited by 10 publications

References 9 publications

Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol

Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol

Absorption and metabolism of genistin in the isolated rat small intestine

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

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