Absorption and metabolism of genistin in the isolated rat small intestine

Abstract

Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 W Wmol/l. The intestinal absorption of genistin was 14.9% ( þ 2.3, n = 9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein. Sulfate derivatives of genistein or genistin were not observed. ß

Function of Traditional Foods and Food Culture in China

“…There is considerable evidence that hydrolysis of the isoflavone glucosides is necessary for their absorption from the gut since the glucosides have not been detected in human plasma 22 . Daidzein and genistein but not their glucoside forms were absorbed from the stomach, and genistein was better absorbed than daidzein 1,19,22 . Genistein had been reported to have a higher antiproliferative effect on the growth of human breast carcinoma and prostate cancer cells compared to genistin 17,18 .…”

Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography

“…Preclinical studies in mice, rats and dogs suggest that resveratrol is readily absorbed and rapidly glucuronidated and sulfated both in the liver and in intestinal epithelial cells [15][16][17].…”

Radiosynthesis and Biodistribution of an125I-labeled Resveratrol Derivative

“…19,23,24 This accounts for gradual decrease of radioactivity with time, and for minimal tumor uptake of the radiolabeled compound 1. In addition, compound 1 can be readily metabolized and eliminated from the body in the forms of glucuronide and sulfate conjugates, and the radioactivity will not be retained in the body.…”