Intestinal microbiota and allergic diseases: A systematic review

Abstract

Evidence suggests that possible imbalances in intestinal microbiota composition may be implicated in the occurrence of allergic diseases. Although several studies published until 2006 indicated a correlation between microbiota composition and allergic symptoms, it has not been possible to distinguish protective microorganisms from those associated with increased risk of allergic diseases. Therefore, the objective of this study was to review the studies published since 2007 that address the intestinal microbiota in allergic diseases. Twenty-one studies were identified after excluding those that performed a clinical intervention before stool collection. In the early microbiota of children who later developed allergies, lower bacterial diversity was observed, with a predominance of Firmicutes; a higher count of Bacteroidaceae; a higher prevalence of the anaerobic bacteria Bacteroides fragilis, Escherichia coli, Clostridium difficile, Bifidobacterium catenulatum, Bifidobacterium bifidum, and Bifidobacterium longum; and a lower prevalence of Bifidobacterium adolescentis, B. bifidum, and Lactobacillus. In the microbiota of allergic children whose intestinal microbiota was assessed at the onset of allergic symptoms, there was a higher count of Bacteroides; a lower count of Akkermansia muciniphila, Faecalibacterium prausnitzii, and Clostridium; a higher prevalence of B. adolescentis; a lower prevalence of B. catenulatum and Staphylococcus aureus; and a lower bacterial diversity.

Three Novel Candidate Probiotic Strains with Prophylactic Properties in a Murine Model of Cow's Milk Allergy

“…Epidemiological studies have illustrated that gut microbiota plays a crucial role in the maintenance of immune homeostasis and influences the occurrence of later diseases (microbial programming) (42). This association between dysbiosis and allergy led us to examine the impact of supplementation on cecal microbiota composition.…”

“…Therefore, it may be linked to a protective effect against allergy or it may be an indicator of the preservation of the microbial diversity, which is reduced in the first week of life in children who will develop atopic eczema (44). LA307 and LA308 strains decreased the bacterial groups that are often associated with allergy, such as enterobacteria and Clostridium cluster XI (42). High-throughput sequencing might help identify specific elements in the microbiota associated with a beneficial impact.…”

Comparison Study of Oropharyngeal Microbiota in Case of Bronchial Asthma and Chronic Obstructive Pulmonary Disease in Different Severity Levels

“…По данным метаанализа, бактерия Bifidobacterium longum ранее обнаруживалась в микробиоте кишечника у детей с аллергической симптоматикой, являясь ее значи-мым компонентом [16]. Нами было показано присутствие этой бактерии в орофарингеальном мазке у больных с тяжелой БА, что отражало сложную взаимосвязь био-топов человеческого организма и комплексного влияния состояния здоровья на микрофлору.…”

Probiotics in allergy treatment: a literature review

“…The first include control of allergenic components, reducing objects that may favor the accumulation of dust, such as carpets, curtains, etc., the composition of microbiota associated with allergic processes, and identified difference between children with or without allergy. They noted that children with allergy had lower biodiversity in microbiota composition 32 .…”