Probiotics in allergy treatment: a literature review

Abstract

Allergy is a exacerbate response of immune system to a triggering element. A probable cause of allergies is gut microbiota composition. It has strong relationship with development of human immune system and this is formed in intrauterine life and early childhood, crucial periods for formation adequate microbiota. In this sense modulation gut microbiota by probiotics could prevent or help in the treatment of allergic diseases such as allergic rhinitis, asthma, atopic dermatitis and food allergy. Studies published to date are controversial. It is difficult to determine whether the probiotic can be used in the treatment and prevention of allergic diseases. Más información: http://creativecommons.org/licenses/by-nc-sa/4.0/ La alergia es una respuesta exacerbada del sistema inmunitario a un elemento desencadenante. Una probable causa de las alergias es la composición del microbioma intestinal. Tiene una fuerte relación con el desarrollo del sistema inmunitario humano y se forma en la vida intrauterina y en la primera infancia, períodos cruciales para la formación de la microbiota adecuada. En este sentido, la modulación de la microbiota intestinal por los probióticos podría prevenir o ayudar en el tratamiento de enfermedades alérgicas como la rinitis alérgica, el asma, la dermatitis ató-pica y la alergia alimentaria. Los estudios publicados hasta la fecha son controvertidos. Es difícil determinar si los probióticos pueden usarse en el tratamiento y prevención de enfermedades alérgicas. PALABRAS CLAVE

Probiotics in Medicine: A Long Debate

“…This hypersensitivity in immune system tolerance mechanisms seems to be modulated by the gut microbiota (90). Dysbiosis has been incriminated for the development of allergies (91).…”

“…Dysbiosis has been incriminated for the development of allergies (91). Probiotics have been successfully used in the treatment of allergic diseases such as allergic rhinitis, asthma, atopic dermatitis and food allergy (90). However, there is still controversy over their use.…”

“…Studies on the role of probiotics in prevention or treatment of food allergies were conducted but with contradictory results (90,110). Heterogeneity of strains, duration and dosage of treatment should probably explain some of the differences.…”

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

“…Allergic reactions often occur due to genetic predisposition and environmental factors. Recently, it is confirmed that human bacterial flora, particularly the intestinal microbiota, plays a crucial role in the development of mucosal immune tolerance during the allergy process; the bacteria interact with innate immune cells like macrophages and dendritic cells and contribute to the maturation of the immune organs and differentiation of Th cells (Crovesy et al., 2017 ).…”