Intestinal metaplasia of the regenerative epithelia in 549 gastric ulcers

Oohara, Takeshi; Tohma, Hiroyuki; Aono, Giichi; Ukawa, Shiro; Kondô, Yoshio

doi:10.1016/s0046-8177(83)80263-9

Cited by 30 publications

(12 citation statements)

References 11 publications

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“…The model of histogenesis presented above is well in accordance with results published before HP was rediscovered: in 1924, Moszkowics [47] postu lated that IM might be the consequence of repeated insults when the undifferentiated regenerative epithelium might have the capability of differentiating into an epithe lium of the intestinal type. Reports published later sup ported this hypothesis [48,49], Another important point to be considered is that, in our material, only 8.1 % of patients were under 30 years of age (n = 219) of which only 4.1% developed IM (n = 9). This finding underscores the rarity of HP gastritis and IM in the under-30-year-old group.…”

Section: Discussionmentioning

confidence: 47%

Antral Intestinal Metaplasia in Helicobacter pylori Gastritis

Eidt

Stolte²

1994

Digestion

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The prevalence of antral intestinal metaplasia (IM) in underlying Helicobacter pylori (HP) gastritis was studied in biopsy specimens of the antral mucosa obtained from 2,692 patients with histologically proven HP gastritis. The prevalence of IM varied in the groups investigated: 47.4% in gastric ulcers, 30.5% in pyloric ulcers, 16.8% in duodenal ulcers, 21.8% in gastritis with no lesions and 9.8% in chronic antral erosions (p < 0.001). A hypothetical model for the role of HP in the development of IM is presented: HP probably promotes mucosal regeneration. The prolonged stimulatory effect on regeneration could then, in the course of time, lead to an increasing likelihood of IM developing.

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Section: Discussionmentioning

confidence: 47%

Antral Intestinal Metaplasia in Helicobacter pylori Gastritis

Eidt

Stolte²

1994

Digestion

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“…19,20 During the regeneration process, the epithelium exhibiting IM either differentiates into normal gastric epithelium or persists. 21 In our study, we divided IM into three categories according to the Filipe classification. 22 Type 1 (complete IM) is frequently associated with benign conditions.…”

Section: Discussionmentioning

confidence: 99%

General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors

Canöz¹,

Belenli²,

Patıroğlu³

2002

Pathol. Oncol. Res.

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“…Endoscopically determined ulceration was defined as clear endoscopic observation of ulcer formation or converging folds without agglutination [10,21]. Pathologically determined ulceration was defined as disruption of the muscularis mucosa with involvement of the submucosal layers [22,23]. Consecutive 4-lm-thick sections were cut from each paraffin-embedded sample and immunolabeled.…”

Section: Endoscopic and Pathological Identification Of Ulceration Andmentioning

confidence: 99%

Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis

et al. 2012

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Background Whether submucosal fibrosis is related to ulceration and affects the outcome of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is unknown. This study aimed to determine ESD outcome in relationship to degree of submucosal fibrosis of gastric epithelial neoplasms and to identify factors predictive of submucosal fibrosis. Methods Eight hundred ninety-one patients with 1,027 gastric epithelial neoplasms were treated by ESD from April 2005 to January 2011. Complete en bloc resection and perforation rates in relationship to degree of submucosal fibrosis (F0, no fibrosis; F1; mild fibrosis; F2, severe fibrosis) were determined during ESD, as well as degree of concordance between endoscopically observed ulceration and pathologically determined ulceration and pathological fibrosis stained with Masson's trichrome. Results The complete en bloc resection rate was significantly low and the perforation rate was high for F2 versus F0/F1 tumors. Ulceration, tumor size C30 mm, and depressed histological type were independent risk factors for severe (F2) fibrosis. No fibrosis (F0) was observed in 77 % (732/951) of endoscopically negative ulceration cases, whereas fibrosis was observed in 100 % (76/76) of endoscopically positive cases. Masson trichrome staining was weak in 97 % (710/732) of F0, moderate in 85 % (181/ 214) of F1, and strong in 100 % (81/81) of F2 cases. Conclusions Histopathological type of submucosal fibrosis predicts outcome of ESD for EGC. Endoscopic indications of F2 submucosal fibrosis are ulceration, tumor C30 mm, and macroscopic depression.

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Intestinal metaplasia of the regenerative epithelia in 549 gastric ulcers

Cited by 30 publications

References 11 publications

Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

General features of gastric carcinomas and comparison of HSP70 and NK cell immunoreactivity with prognostic factors

Outcome of endoscopic submucosal dissection for gastric neoplasm in relationship to endoscopic classification of submucosal fibrosis

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