Antral Intestinal Metaplasia in &lt;i&gt;Helicobacter pylor&lt;/i&gt;&lt;i&gt;i&lt;/i&gt; Gastritis

Eidt, Sebastian; Stolte, Manfred

doi:10.1159/000201116

Cited by 33 publications

(26 citation statements)

References 29 publications

(34 reference statements)

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“…This IM incidence is significantly higher than that in German patients, in whom we found only 28% in H. pylori-infected subjects, and only 5% in uninfected subjects (Bayerdorffer et al, 1992). Similar observations have been made by other investigators (Eidt and Stolte, 1994;Kuipers et al, 1995). However, as IM was more common in H. pylori-infected carcinoma patients than in infected non-carcinoma patients, and also more common in H. pylori-negative carcinoma patients than in uninfected non-carcinoma patients, it is very possible that IM may be a marker for an increased gastric carcinoma risk in H. pyloriinfected as well as uninfected subjects.…”

Section: Discussionsupporting

confidence: 90%

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Miehlke

Hackelsberger²,

Meining³

et al. 1998

Br J Cancer

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Summary In 50 Helicobacterpylori-infected gastric carcinoma patients the corpus gastritis was significantly higher than in matched H. pyloripositive control subjects (P < 0.01). Atrophy and intestinal metaplasia (IM) occurred significantly more often in the antrum of carcinoma patients (P < 0.01). The odds ratio for gastric carcinoma was 8.85 for high-grade corpus gastritis and 8.04 when atrophy in the antrum was present.

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Section: Discussionsupporting

confidence: 90%

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Miehlke

Hackelsberger²,

Meining³

et al. 1998

Br J Cancer

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“…27 Also, the frequency of intestinal metaplasia in duodenal ulcer patients before therapy with either ranitidine or aluminium±magnesium hydroxide was lower than our own previous data had shown. 28,29 Therefore, we cannot de®nitely exclude bias due to sampling error explaining the unexpected low number of patients with intestinal metaplasia before treatment.…”

Section: ±26contrasting

confidence: 52%

H₂‐receptor antagonists and antacids have an aggravating effect on Helicobacter pylori gastritis in duodenal ulcer patients

Meining

Bosseckert

Caspary

et al. 1997

Aliment Pharmacol Ther

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Background: Antacids, such as aluminium–magnesium hydroxide (AlMg(OH)3), or H2‐receptor antagonists, such as ranitidine, are common drugs used for treating peptic ulcer disease and acid‐related symptoms. Methods: In a prospective double‐blind controlled study, 174 patients were randomized to a 4‐week course of treatment with either AlMg(OH)3 (acid‐binding capacity: 280 mval/day) or ranitidine 300 mg for active Helicobacter pylori‐associated duodenal ulcers (as determined by histology and the urease test). Before and after treatment, two biopsy specimens each were obtained from the antrum and corpus, and the grade and activity of gastritis, as well as H. pylori density, were determined using a score ranging from 0 = none to 4 = severe. Results: Pre‐ and post‐treatment histology were available for 138 patients (AlMg(OH)3: 67, ranitidine: 71). Treatment with AlMg(OH)3 significantly increased the activity of corpus gastritis (Wilcoxon signed‐rank: P = 0.0014), while ranitidine treatment significantly increased both the grade and activity of corpus gastritis (P = 0.0002 and P = 0.0001 respectively). In the antrum, both regimens provoked a significant increase in the frequency of intestinal metaplasia, but this may be a consequence of sampling error. Conclusions: Ranitidine and AlMg(OH)3 have an aggravating effect on H. pylori gastritis in duodenal ulcer patients. This should be considered a side‐effect of the respective drugs and is more pronounced with ranitidine.

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“…These results suggest that IM in GCA and GC should be considered as a separate entity. In stomach, IM frequently forms at the antrum (22.9%) but rarely at the fundus (2.8%) [13] . Likewise, most GCs arise from the distal part of the stomach and infrequently from the near part.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

Gao¹,

Wang²,

Fan³

et al. 2005

WJG

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Abstract Abstract Abstract AIM:To characterize the histochemical type and pattern of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China. METHODS:Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio-or chemotherapy was not applied to these patients before surgery. RESULTS:The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues (80.64%, P<0.01). The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues (31.82% and 63.64%, respectively) were significantly higher than those in GC (5.33% and 21.33%, respectively, P<0.01). CONCLUSION:IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.

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Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

Cited by 33 publications

References 29 publications

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

H₂‐receptor antagonists and antacids have an aggravating effect on Helicobacter pylori gastritis in duodenal ulcer patients

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

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Antral Intestinal Metaplasia in <i>Helicobacter pylor</i><i>i</i> Gastritis

Cited by 33 publications

References 29 publications

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori

H2‐receptor antagonists and antacids have an aggravating effect on Helicobacter pylori gastritis in duodenal ulcer patients

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

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H₂‐receptor antagonists and antacids have an aggravating effect on Helicobacter pylori gastritis in duodenal ulcer patients