Intestinal Bacterial Flora and Alzheimer’s Disease

Bostancıklıoğlu, Mehmet

doi:10.1007/s11062-018-9728-0

Cited by 20 publications

(15 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Aβ is a 40–42 amino acid Aβ42 peptide that derived by proteolytic cleavage of amyloid precursor protein (APP). It plays a major role in the AD pathogenesis by initiating neuroinflammatory response in AD [ 81 ]. The APP transgenic mice had a remarkable shift in the gut microbiota diversity than non-transgenic wild-type mice [ 82 ].…”

Section: Interaction Of Gut and Nervous System: Gut–brain Axismentioning

confidence: 99%

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Suganya

Koo

2020

IJMS

176

112

View full text Add to dashboard Cite

The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the largest and vulnerable surface with desirable features to observe foods, nutrients, and environmental factors, as well as to differentiate commensals, invading pathogens, and others. It is well-known that the gut has a strong connection with the central nervous system (CNS) in the context of health and disease. A healthy gut with diverse microbes is vital for normal brain functions and emotional behaviors. In addition, the CNS controls most aspects of the GI physiology. The molecular interaction between the gut/microbiome and CNS is complex and bidirectional, ensuring the maintenance of gut homeostasis and proper digestion. Besides this, several mechanisms have been proposed, including endocrine, neuronal, toll-like receptor, and metabolites-dependent pathways. Changes in the bidirectional relationship between the GIT and CNS are linked with the pathogenesis of gastrointestinal and neurological disorders; therefore, the microbiota/gut-and-brain axis is an emerging and widely accepted concept. In this review, we summarize the recent findings supporting the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. In addition, we highlight the recent advances in improving of neurological diseases by probiotics/prebiotics/synbiotics and fecal microbiota transplantation via the concept of the gut–brain axis.

show abstract

Section: Interaction Of Gut and Nervous System: Gut–brain Axismentioning

confidence: 99%

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Suganya

Koo

2020

IJMS

176

112

View full text Add to dashboard Cite

show abstract

“…Various studies have presented compelling evidence that the gut and central nervous system (CNS) engage in crosstalk with each other, and that the regulation of gut commensal flora could be a promising therapy for neurodegenerative diseases such as Parkinson's (perfectly reviewed in “Pathogenesis of Parkinson's disease—the gut–brain axis and environmental factors”; Klingelhoefer and Reichmann ) and AD (Bonfili et al . ) but first, it is necessary to clarify the nature of the pathophysiological mechanism underlying gut flora causes of AD (Bostanciklioglu ). This study presents a hypothesis on the interaction between the gut microbiome and AD (see Fig.…”

Section: Introductionmentioning

confidence: 99%

The role of gut microbiota in pathogenesis of Alzheimer's disease

Bostancıklıoğlu

2019

Journal of Applied Microbiology

Self Cite

146

View full text Add to dashboard Cite

This paper describes the effects of the gut microbiota on the pathogenesis of Alzheimer's pathology by evaluating the current original key findings and identifying gaps in the knowledge required for validation. The diversity of the gut microbiota declines in the elderly and in patients with Alzheimer's disease (AD). Restoring the diversity with probiotic treatment alleviates the psychiatric and histopathological findings. This presents a problem: How does gut microbiota interact with the pathogenesis of AD? The starting point of this comprehensive review is addressing the role of bacterial metabolites and neurotransmitters in the brain under various conditions, ranging from a healthy state to ageing and disease. In the light of current literature, we describe three different linkages between the present gut microbiome hypothesis and the other major theories for the pathogenesis of AD as follows: bacterial metabolites and amyloids can trigger central nervous system inflammation and cerebrovascular degeneration; impaired gut microbiome flora inhibits the autophagy‐mediated protein clearance process; and gut microbiomes can change the neurotransmitter levels in the brain through the vagal afferent fibres.

show abstract

“…However, disruption of the ecosystem, which could be triggered by high concentrations of antibiotics, suppression of the immune system, and alteration of the gastrointestinal barriers, may lead to pathological processes involving dysbiosis (Angelucci et al, 2019 ). Pro-inflammatory biomarkers produced during dysbiosis has been associated with the development of some neurological disorders (Bostanciklioglu, 2018 ; Shen et al, 2020 ). The community of microbes in the intestine such as bacteria and viruses has been identified as pathogens responsible for several acute and chronic diseases, affecting different organs from their primary site of infection via different mechanisms (Wozniak et al, 2007 ; Piacentini et al, 2011 ; Angelucci et al, 2019 ).…”

Section: Aetiology-based Mechanisms Of Mpp-admentioning

confidence: 99%

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

et al. 2021

View full text Add to dashboard Cite

Microbial infections have been linked to the pathogenesis and pathophysiology of Alzheimer's disease (AD) and other neurodegenerative diseases. The present study aimed to synthesise and assess global evidence of microbial pathogenesis and pathophysiology in AD (MPP-AD) and associated neurodegenerative conditions using integrated science mapping and content analytics to explore the associated research landscape. Relevant MPP-AD documents were retrieved from Web of Science and Scopus according to PRISMA principles and analysed for productivity/trend linked to authors/countries, thematic conceptual framework, and international collaborative networks. A total of 258 documents published from 136 sources to 39.42 average citations/document were obtained on MPP-AD. The co-authors per document were 7.6, and the collaboration index was 5.71. The annual research outputs increased tremendously in the last 6 years from 2014 to 2019, accounting for 66% compared with records in the early years from 1982 to 1990 (16%). The USA (n = 71, freq. = 30.34%), United Kingdom (n = 32, freq. = 13.68%) and China (n = 27, 11.54%) ranked in first three positions in term of country's productivity. Four major international collaboration clusters were found in MPP-AD research. The country collaboration network in MPP-AD was characteristic of sparse interaction and acquaintanceship (density = 0.11, diameter = 4). Overall, international collaboration is globally inadequate [centralisation statistics: degree (40.5%), closeness (4%), betweenness (23%), and eigenvector (76.7%)] against the robust authors' collaboration index of 5.71 in MPP-AD research. Furthermore, four conceptual thematic frameworks (CTF) namely, CTF#1, roles of microbial/microbiome infection and dysbiosis in cognitive dysfunctions; CTF#2, bacterial infection specific roles in dementia; CTF#3, the use of yeast as a model system for studying MPP-AD and remediation therapy; and CFT#4, flow cytometry elucidation of amyloid-beta and aggregation in Saccharomyces cerevisiae model. Finally, aetiology-based mechanisms of MPP-AD, namely, gut microbiota, bacterial infection, and viral infection, were comprehensively discussed. This study provides an overview of MPP-AD and serves as a stepping stone for future preparedness in MPP-AD-related research.

show abstract

Intestinal Bacterial Flora and Alzheimer’s Disease

Cited by 20 publications

References 67 publications

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

The role of gut microbiota in pathogenesis of Alzheimer's disease

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

Contact Info

Product

Resources

About