Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

Ekundayo, Temitope C.; Olasehinde, Tosin A.; Okaiyeto, Kunle; Okoh, Anthony I.

doi:10.3389/fnins.2021.648484

Cited by 15 publications

(12 citation statements)

References 89 publications

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“…Details of the top 20 relevant institutions are shown in Table 2. Several studies have used bibliometrics to assess relevant institutions and authors in a specific field of interest [29,30]. The data from WoS revealed that 1131 authors wrote the 290 documents used for the analysis, with 3.9 authors per document-Table 1.…”

Section: Relevant Institutions and Authorsmentioning

confidence: 99%

A Bibliometric Analysis of Research Trends in Biodegradation of Plastics

Akinpelu

Nchu²

2022

Polymers

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The rapid growth in the production and application of plastic globally has resulted in plastic pollution with a negative impact on the environment, especially the marine ecosystem. One main disadvantage in the majority of polymers is disposal after a useful life span. Non-degradable polymers create severe difficulty in plastic waste management that might end up in landfills or wash into the ocean. The biodegradation of plastic waste is one solution to this critical problem of pollution. Hence, there is a need to consider the advancement of research in this subject area, in pursuit of a way out of plastic pollution. Thus, this study was designed to map the biodegradation of plastic-related research from 2000 to 2021. Statistical information on the topic was recovered from the Web of Science Core Collection and analysed using the bibliometrix package in RStudio statistical software, while data visualisation was conducted via VOSviewer. Our evaluation indicated that the amount of research on the biodegradation of plastic increased over the last decade, and the annual growth rate of publication trends was 11.84%. The study revealed that 1131 authors wrote the 290 analysed documents, with a collaboration index of 4.04. Cooper DG (n = 11) was the most relevant author, McGill University (n = 21) was the most active university, and the Journal of Polymers and the Environment (n = 19) the leading journal. The outcome of this study can guide prospective research and offer vital information for improving the management of plastic waste.

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Section: Relevant Institutions and Authorsmentioning

confidence: 99%

A Bibliometric Analysis of Research Trends in Biodegradation of Plastics

Akinpelu

Nchu²

2022

Polymers

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“…The top 20 active authors, countries and journals were identified according to their productivity using their number of citations and corresponding H-index. The methods of Aria and Cuccurullo [ 33 ] and Ekundayo et al [ 34 ] were used to rate the research outputs on the neurotoxicity of PAHs using a co-word analysis of author–keywords regulated to their root forms by the Porter stemming algorithm. The multidimensional metric scaling (MDS) results of the unsupervised k-means clustering were then visualized.…”

Section: Methodsmentioning

confidence: 99%

Neurotoxicity of Polycyclic Aromatic Hydrocarbons: A Systematic Mapping and Review of Neuropathological Mechanisms

Olasehinde

Olaniran

2022

Toxics

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Several studies present the neurotoxic effects of polycyclic aromatic hydrocarbons (PAHs), a class of environmental pollutants capable of causing neurological deficits. However, a collective review approach to this research topic is scarce. This study presents the effect of PAHs on the central nervous system using a bibliometric approach. The neuropathological mechanisms of PAHs are also highlighted. Published articles were searched for in the Scopus and Web of Science databases from January 1979 to December 2020 using the keywords ‘polycyclic aromatic hydrocarbons’ and ‘neurotoxicity’. The total number of documents retrieved from both databases was 338. Duplicated documents (80) were excluded and 258 articles were used for the final analysis. Our findings revealed that there has been a significant increase in research outputs on this topic in the last ten years. The countries with the highest scientific productivity in this area are USA, China, France and Italy. The result also showed that, in the past few years, global scientific output in research relating to PAH neurotoxicity focused on neurodegeneration, cholinergic function, neurodevelopmental toxicity, behavioural studies, oxidative stress, neuroprotection and therapeutic intervention using different experimental models, including zebrafish, neuronal cell lines, Caenorhabditis elegans and rats. Recent studies also revealed the neuroprotective roles of some natural products against PAH-induced neurotoxicity. However, more investigation involving clinical trials is required to emphasize the observed neurotoxic effects.

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“…In cell and animal models, HSV‐1 causes β‐amyloid peptide aggregation, the creation of senile plaques, and the production of neurofibrillary tangles. Moreover, HSV‐1 produced hyperexcitability and elevated intracellular calcium signals in rat cortical neurons, leading to a change in the amyloid precursor processing pathway and an aberrant increase in amyloid‐β formation (Ekundayo et al., 2021 ).…”

Section: New Findings On Pathogenic Microbes In Admentioning

confidence: 99%

“…Furthermore, Alzheimer's patients’ frontal and temporal cortex and hippocampus have been recently found to have human herpes virus 6 (HHV‐6) (Santpere et al., 2020 ). This virus may create lesions in the infected patient's brain, although not directly connected to AD (Ekundayo et al., 2021 ).…”

Section: New Findings On Pathogenic Microbes In Admentioning

confidence: 99%

Is Alzheimer's disease an infectious neurological disease? A review of the literature

et al. 2022

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Introduction Alzheimer's disease (AD) is a leading cause of dementia around the globe. Its pathogenesis is characterized primarily by the extracellular deposition of amyloid β peptides and intracellular neurofibrillary tangles. Despite the significant investments in neurological research, the exact molecular mechanism of AD pathogenesis is still not fully elucidated. Several studies converge on a hypothesis that pathogenic microbes might play a role in AD progression. Although this hypothesis has been considered relatively weak for decades, it has recently received considerable attention due to increasing evidence on the association between microorganisms and AD. There is a lack of experimental and scientific arguments conveying that these microorganisms engender cognitive and neuropathological deficits and modifications specific to AD, challenging the theory that it could be an infectious neurological disease. This review focuses on recent advances in the infection hypothesis and provides an overview of new findings portraying the significance of pathogenic microbes in AD and the challenges confronting the validity of the hypothesis. Methodology Data were collected from medical journals published on PubMed, Ovid MEDLINE, ScienceDirect, and Embase bibliographical databases with a predefined search strategy. All articles considering neurological disorders, especially AD associated with infectious diseases, were included. Results This work focused on providing an overview of new findings around the relationship between microorganisms and AD, challenges facing the validity of the theory, and recommendations on how the scientific community can best develop alternative approaches to address the pathophysiology of AD. Conclusion While many studies reinforce the suspicion of an infectious etiology of AD, it is important to note that it is yet not validated how microorganisms’ presence in the brain can develop AD due to the limited available evidence. Certainly, ground‐breaking work is mandatory in this field of research, and these reports so far warrant a thorough investigation into how a chronic infection may remain silent while progressing its neuroinflammation. Amid this uncertainty arises the hope that many researchers will take on this challenge and join this endeavor to benefit AD patients worldwide.

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Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

Cited by 15 publications

References 89 publications

A Bibliometric Analysis of Research Trends in Biodegradation of Plastics

A Bibliometric Analysis of Research Trends in Biodegradation of Plastics

Neurotoxicity of Polycyclic Aromatic Hydrocarbons: A Systematic Mapping and Review of Neuropathological Mechanisms

Is Alzheimer's disease an infectious neurological disease? A review of the literature

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