Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Sabater, Carlos; Molina-Tijeras, José Alberto; Vezza, Teresa; Corzo, Nieves; Montilla, Antonia; Utrilla, Pilar

doi:10.1039/c9fo02221j

Cited by 57 publications

(17 citation statements)

References 42 publications

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“…In the same experimental setting modified apple polysaccharides significantly decreased LPS-induced expression of TLR4, COX-2, matrix metallopeptidases (MMP) 2 and 9, iNOS, as well as prostaglandin E2 [55]. Oral application of pectins was also demonstrated to alleviate LPS-induced shock in mice [56] and to decrease the expression of pro-inflammatory markers in model mouse colitis [57]. The direct interaction of pectins with TLR4, thus competing with LPS binding, was proposed to constitute the molecular basis for the modulation of the inflammatory process by pectins [55,58].…”

Section: Discussionmentioning

confidence: 93%

Newly Obtained Apple Pectin as an Adjunct to Irinotecan Therapy of Colorectal Cancer Reducing E. coli Adherence and β-Glucuronidase Activity

Palko-Łabuz

Maksymowicz

Sobieszczańska

et al. 2021

Cancers

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Colorectal cancer (CRC) is the second cause of cancer death worldwide. The composition and enzymatic activity of colonic microbiota can significantly affect the effectiveness of CRC chemotherapy. Irinotecan is a drug widely used to treat colon cancer. However, the transformation of a drug-glucuronide (SN-38G) back to its active form (SN-38) by bacterial β-glucuronidase (GUS) constitutes the primary reason for the observed intestinal toxicity of irinotecan. It was demonstrated that novel enzymatically extracted apple pectin (PC) might be a promising candidate for an adjunct to irinotecan therapy. PC itself reduced the viability of HCT 116 and Caco-2 colorectal cancer cells, induced apoptosis, and increased intracellular reactive oxygen species production. Moreover, PC enhanced the cytotoxic and proapoptotic effect of irinotecan (at concentrations below its IC50), i.e., synergistic effect was recorded. Additionally, PC exhibited potent anti-inflammatory properties and prevented adhesion of prototype adherent-invasive E. coli (AIEC) LF82 strain and laboratory K-12C600 strain to colon cancer cells. PC was also identified to be an effective inhibitor of bacterial GUS activity. Altogether, novel apple pectin was identified as a promising candidate for a supplement to irinotecan therapy that might alleviate its side-effects via inhibition of bacterial GUS and thus increasing its therapeutic efficacy.

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Section: Discussionmentioning

confidence: 93%

Newly Obtained Apple Pectin as an Adjunct to Irinotecan Therapy of Colorectal Cancer Reducing E. coli Adherence and β-Glucuronidase Activity

Palko-Łabuz

Maksymowicz

Sobieszczańska

et al. 2021

Cancers

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“…Wheat bran and peanut fiber also improve intestinal barrier function, changing GM composition and TLR2 expression in pigs ( 100 ). Likewise, chicory pectin and intact guar gum DF exhibit an anti-inflammatory effect in a murine model of DSS-induced colitis decreasing proinflammatory expression ( 101 , 102 ). Additionally, bengkoang DF binds to TLR4, favoring phagocytic activity in J774.1 macrophages ( 103 ).…”

Section: Direct or Indirect Mechanisms Of Dietary Fibers And Bacterial Catabolites And Their Role In Health And Diseasementioning

confidence: 99%

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

2021

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The diverse and dynamic microbial community of the human gastrointestinal tract plays a vital role in health, with gut microbiota supporting the development and function of the gut immune barrier. Crosstalk between microbiota-gut epithelium and the gut immune system determine the individual health status, and any crosstalk disturbance may lead to chronic intestinal conditions, such as inflammatory bowel diseases (IBD) and celiac disease. Microbiota-derived metabolites are crucial mediators of host-microbial interactions. Some beneficially affect host physiology such as short-chain fatty acids (SCFAs) and secondary bile acids. Also, tryptophan catabolites determine immune responses, such as through binding to the aryl hydrocarbon receptor (AhR). AhR is abundantly present at mucosal surfaces and when activated enhances intestinal epithelial barrier function as well as regulatory immune responses. Exogenous diet-derived indoles (tryptophan) are a major source of endogenous AhR ligand precursors and together with SCFAs and secondary bile acids regulate inflammation by lowering stress in epithelium and gut immunity, and in IBD, AhR expression is downregulated together with tryptophan metabolites. Here, we present an overview of host microbiota-epithelium- gut immunity crosstalk and review how microbial-derived metabolites contribute to host immune homeostasis. Also, we discuss the therapeutic potential of bacterial catabolites for IBD and celiac disease and how essential dietary components such as dietary fibers and bacterial tryptophan catabolites may contribute to intestinal and systemic homeostasis.

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“…Sabater and colleagues recently demonstrated that artichoke pectin has anti-inflammatory effects in mice with DSS-induced colitis. The study discovered that mice fed with artichoke pectin had lower pro-inflammatory markers such as TNF-α, ICAM-1, iNOS, and TLR4, implying that artichoke pectin could help alleviate inflammatory bowel disease in a mouse model of colitis [ 63 ].…”

Section: High-fiber Diet For Ibd: What We Knowmentioning

confidence: 99%

Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease

2022

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Crohn’s disease (CD) and ulcerative colitis (UC), two components of inflammatory bowel disease (IBD), are painful conditions that affect children and adults. Despite substantial research, there is no permanent cure for IBD, and patients face an increased risk of colon cancer. Dietary fiber’s health advantages have been thoroughly investigated, and it is recommended for its enormous health benefits. This review article discusses the importance of appropriate fiber intake in managing IBD, emphasizing how optimal fiber consumption can significantly help IBD patients.

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Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Abstract: Anti-inflammatory properties of artichoke pectin and modified fractions (arabinose- and galactose-free) used at two doses (40 and 80 mg kg−1) in mice with colitis induced by dextran sulfate sodium have been investigated.

Cited by 57 publications

References 42 publications

Newly Obtained Apple Pectin as an Adjunct to Irinotecan Therapy of Colorectal Cancer Reducing E. coli Adherence and β-Glucuronidase Activity

Newly Obtained Apple Pectin as an Adjunct to Irinotecan Therapy of Colorectal Cancer Reducing E. coli Adherence and β-Glucuronidase Activity

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

Health Benefits of Dietary Fiber for the Management of Inflammatory Bowel Disease

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