Interventions for treatment and/or prevention of alcohol hangover: Systematic review

Jayawardena, Ranil; Thejani, Thulasika; Ranasinghe, Priyanga; Fernando, D; Verster, Joris C.

doi:10.1002/hup.2600

Cited by 38 publications

(25 citation statements)

References 34 publications

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“…Although there is a high demand for an effective hangover treatment [23], most of the currently marketed hangover treatments lack scientific evidence to support their efficacy. For other compounds that have been evaluated by clinical trials, the effectiveness is normally limited to either mitigating a single hangover symptom or absent completely [24][25][26]. The primary cause for the lack of an effective hangover treatment is the fact that limited investments are made in the development of such treatments, and that the pathology of the alcohol hangover is not yet fully elucidated [25,27,28].…”

Section: The Future For the Research And Treatment Of Alcohol Hangoversmentioning

confidence: 99%

Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

et al. 2020

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The present proceedings offer a summary of the 11th meeting of the Alcohol Hangover Research Group held in April 2019 in Nadi, Fiji. The aim of the meeting was to gather the world’s leading experts in the field of alcohol hangover and share advances and ideas to help better understand the underlying pathology, consequences, and potential therapeutics. Several aspects of alcohol hangover research were discussed, including hangover-associated impairments of cognitive performance and health, novel and best research practice, the validation and use of wearable technology and online tools for off-site data collection, effects of hangover on physical strength performance, new evidence on sex differences in the occurrence and severity of alcohol hangover, and exciting future projects and directions.

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Section: The Future For the Research And Treatment Of Alcohol Hangoversmentioning

confidence: 99%

Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

et al. 2020

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“…The most important reason is that drinkers want to both enjoy the drinking occasion and perform optimally the next-morning. Current scientific literature shows that there are no effective hangover treatments available yet [41][42][43]. Only a fraction of the marketed hangover products have been scientifically investigated, and for none of these products is substantial scientific evidence (i.e., randomized controlled trials in human subjects) available that demonstrates their efficacy in treating or preventing alcohol hangover.…”

Section: Interventions and Treatments For Alcohol Hangovermentioning

confidence: 99%

Proceedings of the 10th Alcohol Hangover Research Group Meeting in Utrecht, The Netherlands

et al. 2020

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The hangover is the most commonly reported negative consequence of alcohol use with several studies reporting the detrimental consequences of hangover on health, economy, and society. Research has emphasized the socioeconomic consequences of experiencing these physical and psychological symptoms in relation to absenteeism, increased risk of having accidents and injuries, and impairment of daily activities, such as job performance and driving a car. During the 10th Alcohol Hangover Research Group meeting, held on 29 April 2018, in Utrecht, The Netherlands, aspects of alcohol hangover were presented with regards to determinants, biological and cognitive consequences and potential treatments. Precursory and posterior factors influencing alcohol hangover, including biological, psychological, behavioral, metabolic aspects, cognitive functioning, and the role of the immune system in the development of alcohol hangover, were presented. In addition, potential preventive measures and treatments of alcohol hangover to reduce the adverse consequences of alcohol consumption and hangover symptoms were discussed. One study revealed that an average of 24% of social and heavy drinkers claimed not to experience hangover symptoms across time. Another study showed that food intake (either healthy or junk food) had no significant impact on next-day hangover severity. Research examining cognitive and psychomotor functioning during hangover revealed impairments in collective problem solving and response inhibition, but not attentional bias towards alcohol-related cues. The alcohol hangover state further significantly impaired driving performance, even for a short commute to work. With regard to the pathology of the alcohol hangover, research was presented that demonstrated increases in saliva cytokine concentrations confirming drinking alcohol and the hangover phase are both associated with an immune response. Other presentations discussed that scientific literature shows that there are no effective hangover treatments available yet. However, although promising, new hangover treatments are currently in development. Taken together, at the 10th Alcohol Hangover Research Group meeting, a comprehensive overview of the causes, consequences, and potential treatments of the alcohol hangover was presented.

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“…Natural products such as vegetables, fruits, and traditional herbs have been developed as potential treatments for alcohol hangovers based on the findings that they promote the elimination of alcohol and alcohol metabolites, inhibit inflammatory mediators, and stimulate the expression of antioxidant enzymes [ 9 ]. However, they improve some symptoms associated with alcohol hangovers such as fatigue, nausea/vomiting, and gastric pain, but not all [ 10 ]. In addition, these products can cause liver toxicity depending on the individual’s health condition [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

et al. 2020

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Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition, OH pre-administration alleviated CYP2E1 activity, ROS production, apoptotic signals, and inflammatory mediators in liver tissues. These results showed that OH and YA enhanced EtOH metabolism and had a protective effect against acute alcohol liver damage. Our findings offer new insights into a single high dose of EtOH drinking and suggest that OH and YA could be used as potential marine functional foods to prevent acute alcohol-induced liver damage.

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Interventions for treatment and/or prevention of alcohol hangover: Systematic review

Abstract: The available evidence suggests that several products are capable of significantly improving some, but not all, of the symptoms related to alcohol hangover. Therefore, further research is necessary to develop clinically effective hangover treatments.

Cited by 38 publications

References 34 publications

Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

Proceedings of the 11th Alcohol Hangover Research Group Meeting, in Nadi, Fiji

Proceedings of the 10th Alcohol Hangover Research Group Meeting in Utrecht, The Netherlands

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

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