Proceedings of the 10th Alcohol Hangover Research Group Meeting in Utrecht, The Netherlands

Abstract

The hangover is the most commonly reported negative consequence of alcohol use with several studies reporting the detrimental consequences of hangover on health, economy, and society. Research has emphasized the socioeconomic consequences of experiencing these physical and psychological symptoms in relation to absenteeism, increased risk of having accidents and injuries, and impairment of daily activities, such as job performance and driving a car. During the 10th Alcohol Hangover Research Group meeting, held on 29 April 2018, in Utrecht, The Netherlands, aspects of alcohol hangover were presented with regards to determinants, biological and cognitive consequences and potential treatments. Precursory and posterior factors influencing alcohol hangover, including biological, psychological, behavioral, metabolic aspects, cognitive functioning, and the role of the immune system in the development of alcohol hangover, were presented. In addition, potential preventive measures and treatments of alcohol hangover to reduce the adverse consequences of alcohol consumption and hangover symptoms were discussed. One study revealed that an average of 24% of social and heavy drinkers claimed not to experience hangover symptoms across time. Another study showed that food intake (either healthy or junk food) had no significant impact on next-day hangover severity. Research examining cognitive and psychomotor functioning during hangover revealed impairments in collective problem solving and response inhibition, but not attentional bias towards alcohol-related cues. The alcohol hangover state further significantly impaired driving performance, even for a short commute to work. With regard to the pathology of the alcohol hangover, research was presented that demonstrated increases in saliva cytokine concentrations confirming drinking alcohol and the hangover phase are both associated with an immune response. Other presentations discussed that scientific literature shows that there are no effective hangover treatments available yet. However, although promising, new hangover treatments are currently in development. Taken together, at the 10th Alcohol Hangover Research Group meeting, a comprehensive overview of the causes, consequences, and potential treatments of the alcohol hangover was presented.

Review of the Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

“…For instance, the FDA has sanctioned a genetically engineered probiotic, Bacillus subtilis ZB183, developed and commercialized by ZBiotics (https://zbiotics.com/ accessed on 8 July 2019). This engineered probiotic, hosting an acetaldehyde dehydrogenase enzyme, transforms acetaldehyde into acetic acid, effectively reducing post-alcohol consumption acetaldehyde accumulation and thus relieving the alcohol hangover [75]. Despite the known safety of the parent strain, the modified variant underwent thorough safety assessments before gaining recognition as safe for general use [76].…”

The Alcohol Hangover Research Group: Ten Years of Progress in Research on the Causes, Consequences, and Treatment of the Alcohol Hangover

“…The objectives of these meetings are to discuss recent findings and future research directions, to raise the profile of alcohol hangover research, and to start new research collaborations. Over the past 10 years, 11 successful AHRG meetings have been held across the world [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. In 2010, the first AHRG meeting was held as a satellite symposium of the Research Society on Alcoholism conference in San Antonio, Texas, USA.…”

“…Subsequent AHRG meetings were held in Paris in 2010 (France), Utrecht in 2011 (The Netherlands), Wolfville in 2012 (Canada), Keele in 2013 (UK), Bellevue in 2014 (USA), Perth in 2015 (Australia), New Orleans in 2016 (USA), Utrecht in 2017 (The Netherlands), Utrecht in 2018 (The Netherlands), and Wailoaloa Beach, Nadi in 2019 (Fiji). Proceedings of most of the AHRG meetings have been published [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”