Interstitial iridium-192 implantation combined with external radiotherapy in anal cancer: Ten years experience

Sandhu, Ajaypal S.; Symonds, Paul; Robertson, Anne S.; Reed, Nick; McNee, S.G.; Paul, Jim

doi:10.1016/s0360-3016(97)00814-6

Cited by 39 publications

(50 citation statements)

References 15 publications

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“…No significant treatment-related toxicity was reported. Local failure rate was 22%, and 48% of failed patients were surgically salvaged [45].…”

Section: Role Of Interstitial Radiotherapymentioning

confidence: 97%

“…Most reported studies have utilized a treatment regimen similar to the original Nigro protocol that combined radiation treatment with 5-fluorouracil (5-FU) and mitomycin. However, the radiation dose delivered was moving from Nigro's 30 Gy [55] towards [45][46][47][48][49][50]57,58].…”

Section: Combined Modality Treatment Retrospective Data On Combined Cmentioning

confidence: 99%

“…Impairment of anal function depends, in large measure, on the extent of prior surgical intervention or on subsequent biopsy, and this can become a permanent problem. Interstitial brachytherapy is associated with a higher incidence of anal dysfunction as a result of tissue necrosis; this ranges from 2%-15% [41][42][43][44][45].…”

Section: Treatment-related Toxicitiesmentioning

confidence: 99%

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Carcinoma of the Anus: Strategies in Management

2002

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The management of anal cancer underwent an interesting transformation over the last two decades. Prior to this period, the standard definitive treatment for carcinoma of the anal canal was abdominal-perineal resection, which necessitated a permanent colostomy. The organ preservation concept appeared following the discovery of a high complete response rate from preoperative combined chemoradiation prior to abdominal-perineal resection.The organ preservation method of treatment rapidly gained popularity and ultimately saved a large number of patients from undergoing abdominal-perineal resection and colostomy. Chemoradiation treatment itself subsequently went through an evolutionary process. Several studies have sought to define the optimal chemotherapeutic regimen as well as radiation treatment dose and fractionation. Ongoing studies attempt to define an optimal treatment regimen that yields a higher cure rate while minimizing toxicity. We review the etiology, epidemiology, and treatment regimens for anal cancer.

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“…No significant treatment-related toxicity was reported. Local failure rate was 22%, and 48% of failed patients were surgically salvaged [45].…”

Section: Role Of Interstitial Radiotherapymentioning

confidence: 97%

Section: Combined Modality Treatment Retrospective Data On Combined Cmentioning

confidence: 99%

Section: Treatment-related Toxicitiesmentioning

confidence: 99%

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Carcinoma of the Anus: Strategies in Management

2002

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“…External beam doses given to a larger pelvic target volume range between 39 and 50 Gy in most series [1,2,6,8,12,17]. Various methods of boost treatment have been applied, among them external beam photon or electron techniques [4,6] and interstitial afterloading with iridium-192 [2,11,12,14]. Also, the timing of boost treatment and the basis for prescribing such a treatment have differed tremendously: Whereas some groups have administered routine boost irradiation in all patients [1,2,4], others have used it as salvage treatment after clinical or histological demonstration of residual disease [6], with treatment interruptions of up to 8 weeks [1,8].…”

Section: Introductionmentioning

confidence: 99%

Intracavitary Afterloading Boost in Anal Canal Carcinoma Results, Function and Quality of Life

et al. 2001

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“…Sandhu et al reported good results for T1 and T2 lesions after interstitial Iridium-192 implantation combined with external beam radiotherapy [21]. For three patients in the current series, we used intraluminal brachytherapy with HDR Iridium-192 after inserting an intra-anal tube.…”

Section: Discussionmentioning

confidence: 93%