Anus‐preservation treatment for anal cancer: Retrospective analysis at a single institution

Chen, Yiwei; Yen, Sang‐Hue; Chen, Shengyu; Huang, Pin I.; Shiau, Chung‐Wai; Liu, Yuming; Wang, Ling-Wei

doi:10.1002/jso.20747

Cited by 6 publications

(3 citation statements)

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“…However, some studies claiming to demonstrate a QoL impact of anal cancer treatment have done so with inappropriate QoL measures, for example, one comparison of QoL following radiochemotherapy and surgery was based on data extracted from medical records [50] which will give a very incomplete assessment. Generic cancer QoL measures such as the EORTC QLQ-C30 are designed to capture issues relevant to all cancer types but are insensitive to unique disease-related features.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of the quality of life issues associated with anal cancer and its treatment with radiochemotherapy

Sodergren

Vassiliou

Dennis

et al. 2015

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PurposeRadiochemotherapy is the standard of care for the treatment of anal carcinoma achieving good loco-regional control and sphincter preservation. This approach is however associated with acute and late toxicities including haematological, skin, bowel function and genito-urinary complications. This paper systematically reviews studies addressing the quality of life (QoL) implications of anal cancer and radiochemotherapy. The paper also evaluates how QoL is assessed in anal cancer. MethodsMedline, EMBASE, CINAHL, PsycInfo, Web of Science and the Cochrane Library were searched for publications (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) reporting the effects on patients of anal cancer and radiochemotherapy. ResultsOf the 152 papers reporting treatment-related effects on patients, only 11 provided a formal assessment of QoL. In the absence of an anal cancer specific measure, QoL was assessed using generic cancer instruments such as the core EORTC quality of life questionnaire (EORTC QLQ-C30) or colorectal cancer tools such as the EORTC QLQ-CR29. Bowel function, particularly diarrhoea, and sexual problems were the most commonly reported QoL concerns. The review of QoL issues of anal cancer patients treated with radiochemotherapy is limited by the QoL assessment measures used. It is argued that certain treatment-related toxicities, for example skin-induced radiation problems are overlooked or inadequately represented in existing measures. ConclusionsThis review emphasises the need to develop an anal cancer specific QoL measure and to incorporate QoL as an outcome of future trials in anal cancer. The results of this review are informative to clinicians and patients in terms of treatment decision making.

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Section: Discussionmentioning

confidence: 99%

Systematic review of the quality of life issues associated with anal cancer and its treatment with radiochemotherapy

Sodergren

Vassiliou

Dennis

et al. 2015

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“…We observed that the performance status was an independent predictor for OS 17,28,29. Martenson, et al17 reported that patients with a good performance status had much better 5-year OS as compared to that of the patients with a poor performance status (74% vs. 55%, respectively; p =0.045).…”

Section: Discussionmentioning

confidence: 55%

“…Martenson, et al17 reported that patients with a good performance status had much better 5-year OS as compared to that of the patients with a poor performance status (74% vs. 55%, respectively; p =0.045). Moreover, Chen, et al29 showed that the performance status was a significant prognostic factor for OS ( p <0.001).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Chemoradiation for Anal Cancer Patients

et al. 2013

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PurposeThe aim of this study was to evaluate long-term oncologic outcomes after concurrent chemoradiation treatment for anal cancer.Materials and MethodsBetween January 1979 and December 2008, the records of 50 consecutive patients with anal cancer and who were treated by chemoradiation or radiation only with a curative intent were retrospectively reviewed. The oncologic outcomes and the risk factors for recurrence were analyzed.ResultsOf the 50 patients, 49 underwent concurrent chemoradiation and one underwent radiation only. After these definitive treatments, 43 (86.0%) achieved a clinical complete response. During the median follow-up of 60 months (range: 2-202 months), the 5-year overall survival, disease-free survival, and locoregional recurrence-free survival were 84.2%, 72.7%, and 69.9%, respectively. Multivariate analysis revealed that the performance status (p=0.031) and a clinical complete response (p=0.039) were the independent predictors for overall survival; lymph node involvement (p=0.031) was the only independent predictor for disease-free survival.ConclusionThe performance status and a clinical complete response may be reliable predictors of survival after chemoradiation for anal cancer. The addition of irradiation to the inguinal area may not be significantly associated with the outcomes.

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Squamous Cell Carcinoma of the Anal Canal

Kulaylat

2014

Surgical Oncology

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Anus‐preservation treatment for anal cancer: Retrospective analysis at a single institution

Abstract: With careful monitoring of toxicity, non-surgical anus-preservation treatment with good tumor control is feasible.

Cited by 6 publications

References 20 publications

Systematic review of the quality of life issues associated with anal cancer and its treatment with radiochemotherapy

Systematic review of the quality of life issues associated with anal cancer and its treatment with radiochemotherapy

Long-Term Outcomes of Chemoradiation for Anal Cancer Patients

Squamous Cell Carcinoma of the Anal Canal

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