Interrelations Between Inflammatory and Oxidative Stress Biomarkers in Obese Women with Two Complications (Hypertension, Diabetes)

Abstract

Background and aims: Interaction between oxidative stress and inflammation has not been comprehensively investigated in the association obesitydiabetes -hypertension.Our aim was to investigate interrelations between inflammatory and oxidative stress biomarkers in obese women with two complications (hypertension, type 2 diabetes). Material and Methods: 54 obese patients without complications, 46 diabetic patients with obesity, 48 hypertensive diabetic obese women, and 120 healthy controls were recruited from the department of nuclear medicine (Algeria). Inflammatory and oxidative stress biomarkers were assayed by appropriate methods. Results: Inflammatory markers were significantly higher in all obese groups compared to controls. Elevated pro-oxidants and decreased antioxidant markers were noted in obese women. These alterations were accentuated when obesity was associated with hypertension and diabetes. A positive interrelationship between inflammatory mediators and oxidative status, and a negative one with antioxidants were noted during obesity. Hypertension and diabetes enhanced these correlations. Leptin, C-reactive protein, catalase, superoxide dismutase, ion superoxide, peroxynitrite were found to be the best inflammatory and oxidative stress biomarkers that can predict diabetes and hypertension in obese women. Conclusions: oxidative stress and inflammation were intimately interconnected in women obesity associated with diabetes and hypertension. key words: Hypertension, inflammation, obesity, oxidative stress, type 2 diabetes mellitus. Background and aimsObesity is characterized by a chronic lowgrade inflammation due to the expansion of adipocytes (hypertrophy), and by adipogenesis (hyperplasia) of adipose tissue with high proinflammatory and low anti-inflammatory

Endothelial Microparticle as an early Marker of Endothelial Dysfunction in Patients with Essential Hypertension: A Pilot Study

“…There was direct relationship between inflammatory, oxidative stress and procoagulant markers and inverse relationship with eNOS which catalyzes formation of the vasodilator, nitric oxide (NO). According to Karaouzeneet al, inflammatory and pro- oxidant markers are elevated with decrease in antioxidant markers in obese women with hypertension [12]. In this study, percentage of EMPs in group III with a value of 13.51 ± 4.38 and Median Fluorescence Intensity (MFI) of 3.0 ± 0.19 was the highest in hypertensive patients with end organ damage (Fig.…”