Endothelial Microparticle as an early Marker of Endothelial Dysfunction in Patients with Essential Hypertension: A Pilot Study

Silambanan, Santhi; Hermes, R.; Bhaskar, Emmanuel; Gayathri, S.

doi:10.1007/s12291-019-00861-w

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…The first stage of inflammatory reactions is the long-term chronic inflammation in the aorta in the patients with hypertension. Inflammation, oxidative stress and genetic predisposition play great roles in the pathogenesis of hypertension [13]. Chronic low-grade inflammation exists in the course of hypertension, triggers the progress of hypertension and contributes to vascular remodeling [9,14,15].…”

Section: Discussionmentioning

confidence: 99%

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Zhao

Bie

2020

BMC Cardiovasc Disord

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Background: Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD. Methods: We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (−) group (oxygenation index> 200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve. Results: A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85 ± 0.60 vs 37.64 ± 0.44°C, P = .005), higher levels of CRP (42.70 ± 28.27 vs 13.90 ± 18.70 mg/L, P = .000) and procalcitonin (1.07 ± 3.92 vs 0.31 ± 0.77μg/L, P = .027), and lower levels of albumin (34.21 ± 5.65 vs 37.73 ± 4.70 g/L, P = .000). Spearman's rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%. Conclusions: The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.

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Section: Discussionmentioning

confidence: 99%

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Zhao

Bie

2020

BMC Cardiovasc Disord

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“…The rst stage of in ammatory reactions is the long-term chronic in ammation in the aorta in the patients with hypertension. In ammation, oxidative stress and genetic predisposition play great roles in the pathogenesis of hypertension [13]. Chronic low-grade in ammation exists in the course of hypertension, triggers the progress of hypertension and contributes to vascular remodeling [9,14,15].…”

Section: Discussionmentioning

confidence: 99%

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Zhao¹,

Bie

2020

Preprint

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Background Acute aortic dissection (AAD) is an acute life-threatening cardiovascular disease, which is frequently complicated with oxygenation impairment (OI). We aim to investigate predictors of the development of OI in the patients with AAD.Methods We retrospectively collected clinical data of AAD in hypertensive patients from July 2012 to March 2020. The patients included in this study were divided into OI (+) group (oxygenation index≤200) and OI (-) group (oxygenation index>200). Both groups were compared according to demographic and clinical characteristics, and laboratory findings. Characteristics of hypertension in the patients with AAD were described. Predictors for the development of OI were assessed. And cutoff values were determined by receiver operating characteristics (ROC) curve.Results A total of 208 patients were included in this study and the incidence of OI was 32.2%. In OI (+) group, patients had significantly higher peak body temperature (37.85±0.60 vs 37.64±0.44℃, P= .005), higher levels of CRP (42.70±28.27 vs 13.90±18.70mg/L, P= .000) and procalcitonin (1.07±3.92 vs 0.31±0.77ug/L, P= .027), and lower levels of albumin (34.21±5.65 vs 37.73±4.70g/L, P= .000). Spearman’s rank correlation test showed that the minimum oxygenation index was positively correlated with albumin, and was negatively correlated with the peak body temperature, serum CRP, procalcitonin, BNP and troponin. The stepwise multiple linear regression analysis showed that the peak body temperature, serum CRP and albumin were independently associated with development of OI. An optimal cutoff value for CRP for predicting OI was ≥9.20 mg/L, with a sensitivity of 91.0% and a specificity of 61.0%.Conclusions The peak body temperature, serum CRP and albumin were independent predictors of OI development in the patients with AAD. The serum CRP on admission≥9.20 mg/L might be a valuable and reliable indicator in predicting the development of OI.

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“…Detecting it at an early stage before any clinical manifestations develop would be a cost-effective preventive strategy. A growing amount of evidence has recently indicated that endothelial microparticles (EMPs)-also termed endothelial microvesicles-may have a potential role as surrogate biomarkers for endothelial dysfunction [8][9][10][11][12][13][14]. Endothelial microparticles are vesicles measuring 0.1-1 µm that shed from the cell surface of the endothelium in response to cell activation or apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…Some methods also include the detection of phosphatidylserine with phosphatidylserine ligands, such as annexin V. Phosphatidylserine is a phospholipid present on the inner surface of cells that will also be exposed during apoptosis or activation [15]. Clinically, raised EMP levels have been shown to be associated with cardiovascular and metabolic diseases, such as atherosclerosis [16], hypertension [11,17,18], acute coronary syndrome [14,19], stroke [20], diabetes [21,22], and obesity [23]. CD31, CD62e and CD144, with or without double labelling with annexin V combination, are among the most extensively studied cell surface antigens commonly associated with endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Microparticles as Potential Biomarkers in the Assessment of Endothelial Dysfunction in Hypercholesterolemia

et al. 2022

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Background and Objectives: Endothelial microparticles (EMP) particularly CD31+/42−/AV+, CD144+/AV+ and CD62e+/AV+ have been reported as having increased in cardiovascular-related diseases, making them potential biomarkers for endothelial dysfunction. This study aimed to compare these EMPs in patients with hypercholesterolemia and healthy controls and to correlate their levels with endothelium-dependent vasodilation (EDV) assessed via pulse wave analysis (PWA); an established method of assessing endothelial function. Materials and Methods: EMPs from 88 subjects (44 hypercholesterolemia patients and 44 controls) were quantified from whole blood using flow cytometry analysis. Endothelial function was determined using PWA combined with pharmacological challenge. Results: CD31+/42−/AV+ (3.45 ± 4.74 count/µL vs. 1.33 ± 4.40 count/µL; p = 0.03), CD144+/AV+ (7.37 ± 12.66 count/µL vs. 1.42 ± 1.71 count/µL; p = 0.003) and CD62e+/AV+ (57.16 ± 56.22 count/µL vs. 20.78 ± 11.04 count/µL; p < 0.001) were significantly elevated in the hypercholesterolemic group compared with the controls, respectively. There was a significant inverse moderate correlation between all circulating EMPs and EDV: CD31+/42−/AV+ (r = −0.36, p = 0.001), CD144+/AV+ (r = −0.37, p = 0.001) and CD62e+/AV+ (r = −0.35, p = 0.002). Conclusions: All EMPs were raised in the patients with hypercholesterolemia, and these values correlated with the established method of assessing endothelial function.

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Endothelial Microparticle as an early Marker of Endothelial Dysfunction in Patients with Essential Hypertension: A Pilot Study

Cited by 5 publications

References 20 publications

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Predictors for the development of preoperative oxygenation impairment in acute aortic dissection in hypertensive patients

Endothelial Microparticles as Potential Biomarkers in the Assessment of Endothelial Dysfunction in Hypercholesterolemia

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