No abstract

No abstract

Background and aims: Interaction between oxidative stress and inflammation has not been comprehensively investigated in the association obesitydiabetes -hypertension.Our aim was to investigate interrelations between inflammatory and oxidative stress biomarkers in obese women with two complications (hypertension, type 2 diabetes). Material and Methods: 54 obese patients without complications, 46 diabetic patients with obesity, 48 hypertensive diabetic obese women, and 120 healthy controls were recruited from the department of nuclear medicine (Algeria). Inflammatory and oxidative stress biomarkers were assayed by appropriate methods. Results: Inflammatory markers were significantly higher in all obese groups compared to controls. Elevated pro-oxidants and decreased antioxidant markers were noted in obese women. These alterations were accentuated when obesity was associated with hypertension and diabetes. A positive interrelationship between inflammatory mediators and oxidative status, and a negative one with antioxidants were noted during obesity. Hypertension and diabetes enhanced these correlations. Leptin, C-reactive protein, catalase, superoxide dismutase, ion superoxide, peroxynitrite were found to be the best inflammatory and oxidative stress biomarkers that can predict diabetes and hypertension in obese women. Conclusions: oxidative stress and inflammation were intimately interconnected in women obesity associated with diabetes and hypertension. key words: Hypertension, inflammation, obesity, oxidative stress, type 2 diabetes mellitus. Background and aimsObesity is characterized by a chronic lowgrade inflammation due to the expansion of adipocytes (hypertrophy), and by adipogenesis (hyperplasia) of adipose tissue with high proinflammatory and low anti-inflammatory

Dietary fiber is a group of food components which is the subject of many studies on several aspects of human health. Recent research demonstrate that dietary fiber intake is associated with reduced diabetes risk. The aim of the present work was to test the effect of dietary fiber such as cellulose and mucilage on disorders of lipid metabolism induced by experimental diabetes in the aged Wistar rats. Diabetes was induced by intraperitoneal injection of streptozotocin. Aging male Wistar rats diabetic and control rats were fed highly-pure-cellulose-mucilage-enriched (HPCME) diet or control diet for 2 months. At the end of study, blood samples and tissue are collected for de-termination of biochemical parameters (glucose, total cholesterol, triglycer-ides and lipoproteins) and lipases activities. 2 months of HPCME diet intake by diabetic aged rats improves diabetic control, induced a decrease of body weight, a reduction of plasma lipid concentration, lower blood-glucose and a significant decrease in expression of pathway lipolytic enzyme activities va-lues witch decrease the prevalence of the specific disorders of diabetes. This study suggests that dietary fiber (HPCME), has an important physiological effect on glucose and lipid metabolism during aging which reduces the risk of developing complications of diabetes.

No abstract