Interrater reliability of the international consensus definition of drug-resistant epilepsy: A pilot study

Hao, Xiao ting; Wong, I.; Kwan, Patrick

doi:10.1016/j.yebeh.2011.06.035

Cited by 47 publications

(17 citation statements)

References 9 publications

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“…In interobserver and intraobserver comparisons, the ILAE definition obtained the highest kappa scores (0.77 and 0.82), thus proving its reliability. Similarly, the excellent interobserver agreement of the ILAE definition was recently demonstrated by Hao et al, 17 whose results yielded a kappa score of 94%. However, it was also found that the Camfield and Camfield, Kwan and Brodie, and Berg et al definitions met criteria for reliability and validity.…”

Section: Discussionsupporting

confidence: 68%

A validation of the new definition of drug‐resistant epilepsy by the International League Against Epilepsy

et al. 2014

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SUMMARYObjective: To establish applicability, the recently proposed International League Against Epilepsy (ILAE) consensus on drug-resistant epilepsy (DRE) requires testing in clinical and research settings. This study evaluates the reliability and validity of these criteria in a clinical population. Methods: In phase I, two independent evaluators reviewed 97 randomly selected medical records of patients with epilepsy at two separate intervals. Both ILEA consensus and standard diagnostic criteria were employed. Kappa, weighted kappa, and intraclass correlation coefficient (ICC) were used to determine interobserver and intraobserver variability. In phase II, ILAE consensus criteria were applied to 250 patients with epilepsy to determine risk factors associated with development of DRE and to calculate point prevalence.Results: The interobserver agreement of the four definitions was as follows: Berg (0.56), Kwan and Brodie (0.58), Camfield and Camfield (0.69), and ILAE (0.77). The intraobserver agreement of the four definition was as follows: Berg (0.81), Kwan and Brodie (0.82), Camfield and Camfield (0.72), and ILAE (0.82). The prevalence of DRE was the following: with the Berg's definition was 28.4%, Kwan and Brodie 34%, Camfield and Camfield 37%, and with ILAE was 33%. Significance: This is first study to establish reliability and validity of ILAE criteria for the diagnosis of DRE. This new definition compares favorably with previously established constructs, which continue to retain clinical significance. KEY WORDS: Drug-resistant epilepsy, Validation, Reliability, Validity, Consensus.Epilepsy affects 50 million people worldwide.1 It is estimated that between 6% and 69% of patients fail to respond to standard medical and surgical therapies and continue to experience debilitating refractory seizures. These patients are classified as having drug-resistant epilepsy (DRE), a diagnosis with poor prognostic implications that include premature death, physical injury, psychosocial dysfunction, and reduced quality of life.2,3 The prevalence of DRE is not consistently defined and tends to vary among studies, owing to issues with population selection, sample size, classification, terminology, and characterization of seizure intractability. 1,4,5 Conceptual elements of DRE are documented in the literature with terminology that is nonstandard and potentially conflicting, albeit abundant. Various prefixes such as "pharmaco-resistant-," "refractory-," "drug refractory-," or "intractable-" have been applied to describe this form of epilepsy. Recognizing the need for a consistent definition to guide classification, diagnosis, epidemiology, and research, the International League Against Epilepsy (ILAE) generated the unified concept of DRE in 2008. Two years prior, Berg et al. 6 applied six different definitions of DRE to a cohort of 613 children with newly diagnosed epilepsy. Of these six criteria, three diagnostic criteria-namely those proposed by Camfield and Camfield,7 Kwan and Brodie, 8 and Berg's own 9,10 -produced the high...

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Section: Discussionsupporting

confidence: 68%

A validation of the new definition of drug‐resistant epilepsy by the International League Against Epilepsy

et al. 2014

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“…The present study also showed that, for individuals with epilepsy, social and personal relationships are factors that negatively interfere in QoL, which in turn compromise the knowledge and self-perception of such individuals about their disease, which in general leads to isolation, family dependence, and low self-esteem. The domains social and personal life, self-perception (feeling about oneself), and change, which in the mentioned study showed lower scores, may lead EIs to family withdrawal and limited social life, as well as to restricted participation in their treatment and, therefore, in the relations established with the professionals in charge (9,10) .…”

Section: Discussionmentioning

confidence: 66%

“…Tumors, cortical dysplasias, vascular malformations, hippocampal sclerosis, and traumas are among the underlying etiologies of TLE. Individuals with TLE are at higher risk of premature death, are more susceptible to falls and injuries, and tend to present psychosocial problems and reduced quality of life (QoL) (9) . In order to analyze the QoL of EIs, multidisciplinary teams should assess the impact that clinical manifestations of this disease have on these individuals' lives.…”

Section: Introductionmentioning

confidence: 99%

A pessoa com epilepsia: percepções acerca da doença e implicações na qualidade de vida

Hopker

Berberian

Massi

et al. 2017

CoDAS

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RESUMO Objetivo Analisar percepções de pessoas com epilepsia acerca da doença e seu impacto na qualidade de vida. Método Trata-se de um estudo qualitativo e quantitativo de corte transversal realizado em hospital de referência terciária, vinculado ao Sistema Único de Saúde. Participaram do estudo 30 pessoas com o diagnóstico de epilepsia de lobo temporal refratária. Foi aplicado questionário para a coleta dos dados sociodemográficos e clínicos, bem como das percepções acerca da doença. Avaliou-se a qualidade de vida por meio do Subjective Handicap of Epilepsye e o estigma pela Escala Estigma na Epilepsia. Resultados Foi encontrada significância na relação entre estigma e qualidade de vida com os domínios trabalho e social/pessoal, entre estigma e percepções sobre a epilepsia. As respostas fornecidas pelos participantes foram organizadas em quatro categorias: definições e causas; crises e tratamento; impacto familiar e social; impacto na vida das pessoas. Conclusão Evidenciou-se o predomínio do conhecimento restrito dos participantes acerca da epilepsia e o impacto negativo que o estigma relacionado a tal doença acarreta na qualidade de vida. Pode-se verificar que a qualidade de vida e o estigma estão diretamente relacionados ao conhecimento dos participantes sobre a epilepsia. Ressalta-se a necessidade do implemento de programas e ações que objetivem: proporcionar maior conhecimento sobre a epilepsia por parte do paciente e de seus familiares; favorecer a comunicação entre os profissionais de saúde e as PCEs; promover a participação do paciente e de seus familiares na gestão do tratamento.

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“…The inter-rater reliability of the new drug resistance definitions, established by the ILAE Task Force, was previously evaluated by Hao et al [7]. The results of this work provided early evidence that the definition has a very high degree of inter-rater reliability.…”

Section: Discussionmentioning

confidence: 85%

“…Hao and al. [7] suggested that the main problems with respect to classification arose in the undefined group, because of problems regarding insufficient information or when a treatment had not been tried adequately.…”

Section: Discussionmentioning

confidence: 99%

ESPERA study: Applicability of the new ILAE criteria for antiepileptic drug resistance of focal epilepsies in current clinical practice

Toffol

Zélicourt

Vespignani

et al. 2012

Epilepsy & Behavior

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Interrater reliability of the international consensus definition of drug-resistant epilepsy: A pilot study

Cited by 47 publications

References 9 publications

A validation of the new definition of drug‐resistant epilepsy by the International League Against Epilepsy

A validation of the new definition of drug‐resistant epilepsy by the International League Against Epilepsy

A pessoa com epilepsia: percepções acerca da doença e implicações na qualidade de vida

ESPERA study: Applicability of the new ILAE criteria for antiepileptic drug resistance of focal epilepsies in current clinical practice

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