Interpretation of bronchograms and chest radiographs in patients with chronic sputum production.

Currie, D C; Cooke, Julie; Morgan, A. G.; Kerr, I.H.; Delany, David J.; Strickland, Basil; Cole, P J

doi:10.1136/thx.42.4.278

Cited by 70 publications

(29 citation statements)

References 13 publications

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“…Although historically the serial evaluation of chest radiographs has been reported as being suitable to document progression of CF [42] and non-CF bronchiectasis [43], it has been well established that HRCT of the chest provides more detailed information [44][45][46]. Utilising HRCT scans and a validated CT score in this study is a major strength in comparison with other work that uses chest radiograph assessment to compare with exercise.…”

Section: Discussionmentioning

confidence: 96%

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

Edwards

Narang²,

Li³

et al. 2004

European Respiratory Journal

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In paediatric bronchiectasis, there has been limited work on the relationship between disease severity as assessed by exercise limitation and high resolution computed tomography (HRCT).An observational study was performed on 36 children who completed a questionnaire, physical examination, spirometry and sputum analysis, followed by a low dose of radiation protocol chest computed tomography (CT) scan and cycle ergometry incremental exercise test. A modified Bhalla score was used to score the HRCT abnormalities. The exercise variables used to assess functional status were heart rate, oxygen consumption, oxygen saturations and time of exercise. The results were compared with established normal paediatric values.The median (range) age of the children was 13 yrs (10.6-17.1). Age, sex, height, weight or pubertal status were equally distributed between the children with cystic fibrosis (CF) or non-CF bronchiectasis. The children with non-CF bronchiectasis had a lower median forced expiratory volume in one second % predicted than the children with CF (69% versus 76%, respectively). The distribution of lung disease differed between the two groups. The children with CF bronchiectasis had predominantly right upper lobe disease, and scored higher for the presence and extent of bronchiectasis. Otherwise, there was no statistical difference in the overall CT score or the individual CT parameters between the groups. There was evidence of exercise limitation in both CF and non-CF bronchiectasis compared to normal children. No consistent relationships were identified between the lung function parameters, HRCT findings or exercise parameters in either disease group.In this study, high resolution computed tomography features were not found to be markers of exercise capacity. As spirometry, high resolution computed tomography features and exercise testing give different information in children with cystic fibrosis and non-cystic fibrosis bronchiectasis, the current authors suggest all three may be required for the comprehensive assessment of respiratory status.

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Section: Discussionmentioning

confidence: 96%

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

Edwards

Narang²,

Li³

et al. 2004

European Respiratory Journal

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“…1,5,7 In infants and pre-school children with bronchiectasis, it is mostly challenging to obtain high quality sputum. Moreover, chest radiography 9 and spirometric tests are not sensitive enough to predict the exacerbations. 8,10 In the present study, MPV values are found significantly lower during acute exacerbation periods of bronchiectasis when compared to non-exacerbation periods and the values of healthy children.…”

Section: Discussionmentioning

confidence: 99%

“…2,6,7 Besides, chest radiography and spirometric analysis are not sensitive enough in monitoring disease progression and predicting exacerbations. 8,9,10 Novel and appropriate parameters are needed to predict exacerbations and follow disease activity in children. It is known that platelets play a role in either pathogenesis of chronic inflammation during the development of bronchiectasis or progression and exacerbation of the disease.…”

Section: Introductionmentioning

confidence: 99%

Does Mean Platelet Volume in Children with Bronchiectasis Predict Exacerbations?

Uysal¹,

Tunçel²,

Erge³

et al. 2014

UHOD

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Bronchiectasis is a parenchymal lung disease which develops as a consequence of chronic inflammation and recurrent pulmonary infections. It is known that platelets have a role in inflammation and progressive pulmonary damage. Mean platelet volume (MPV) values as a marker of platelet activation, and might be used as an indicator of inflammation. Eighty-one children with the diagnosis of bronchiectasis followed between July 2010-July 2012 were enrolled in the study. The demographical data of patients were recorded and complete blood count (CBC) and MPV values were screened via hospital patient database. Complete blood count and MPV values were compared to age and sex-matched healthy children's data. In addition, CBC and MPV values were compared among chronic disease period without any exacerbation and exacerbation period in the children with bronchiectasis. The study was consisted of 81 children with bronchiectasis and 79 healthy controls. There was no significant difference between MPV values of non-exacerbation period and control group (p>0,05).Mean platelet volumes during acute exacerbation were significantly lower when compared with the values of non-exacerbation period and controls (p= 0,02 and p= 0,01 respectively). MPV and platelet counts (r = -0,502, p= 0,01) as well as leucocyte count and hemoglobin levels were inversely correlated with each other in exacerbation period (r= -439, p= 0.00). Mean platelet volume measured at during acute exacerbation were significantly decreased in children with bronchiectasis. With the result of present study, we suggest that MPV might be used as a predictor marker for diagnosis of acute exacerbations in children with bronchiectasis.

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“…Currie et al (1987) in a study of 27 patients with chronic sputum production evaluated bronchographically showed that there was a significant interobserver variability when studies were interpreted by two well-trained bronchographers. Agreement was reached only in 19 out of 27 (70%) by one radiologist only.…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that bronchography may be more limited in its utility than previously thought. 1 We did a random study in 50 patients in our hospital who were clinically suspected to have bronchiectasis. HRCT's were performed on these patients on Toshiba sub-second Spiral CT Scan.…”

Section: Discussionmentioning

confidence: 99%

Role of HRCT in Evaluation of Bronchiectasis

M¹,

S²,

Sapna³

2016

jemds

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BACKGROUNDBronchiectasis is defined as a localised, irreversible dilatation of the bronchial tree. Bronchiectasis is a chronic and progressive lung disease and can lead to chronic respiratory failure. HRCT has emerged as the imaging modality of choice for evaluating suspected cases of bronchiectasis. HRCT is excellent in characterisation of the type of bronchiectasis and extent of lung involvement. AIMS 1. To study the role of HRCT in diagnosis of bronchiectasis. 2. To study regional distribution of bronchiectasis on HRCT. 3. To characterise bronchiectasis morphologically and to determine aetiologies of bronchiectasis wherever possible. MATERIAL AND METHODSA prospective study of 50 patients was done in the Department of Radiology and Imaging at Kakatiya Medical College and MGM General Hospital, Warangal. PATIENT SELECTIONPatients of all age groups were selected in whom clinically bronchiectasis was suspected. Ours was a random study for a period of three years and no specific criteria were laid down for patient selection. From May 2005 -April 2008, 50 patients clinically suspected to have bronchiectasis were subjected to chest radiograph and HRCT examination. RESULTSIn our study by co-relating HRCT findings and clinical history an accurate diagnosis was made in 46 cases, i.e. 76.6% which was confirmed by laboratory investigations. In our study 23 patients (46%) had pulmonary tuberculosis, in 8 patients (16%) no cause was found, 16 patients (32%) had history of recurrent childhood infections, 2 patients (4%) had bronchial asthma and COPD and 1 patient (2%) had allergic bronchopulmonary aspergillosis. In this study incidence was common in the age group of 21-30 years and is more common in males than females. Bilateral involvement is more common than unilateral involvement. CONCLUSIONIn a given clinical setting suggestive of bronchiectasis, HRCT serves as the best modality in confirming the diagnosis of bronchiectasis. HRCT is definitely superior to chest radiographs in the detection of bronchiectasis.

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Interpretation of bronchograms and chest radiographs in patients with chronic sputum production.

Cited by 70 publications

References 13 publications

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

Does Mean Platelet Volume in Children with Bronchiectasis Predict Exacerbations?

Role of HRCT in Evaluation of Bronchiectasis

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