Does Mean Platelet Volume in Children with Bronchiectasis Predict Exacerbations?

Abstract

Bronchiectasis is a parenchymal lung disease which develops as a consequence of chronic inflammation and recurrent pulmonary infections. It is known that platelets have a role in inflammation and progressive pulmonary damage. Mean platelet volume (MPV) values as a marker of platelet activation, and might be used as an indicator of inflammation. Eighty-one children with the diagnosis of bronchiectasis followed between July 2010-July 2012 were enrolled in the study. The demographical data of patients were recorded and complete blood count (CBC) and MPV values were screened via hospital patient database. Complete blood count and MPV values were compared to age and sex-matched healthy children's data. In addition, CBC and MPV values were compared among chronic disease period without any exacerbation and exacerbation period in the children with bronchiectasis. The study was consisted of 81 children with bronchiectasis and 79 healthy controls. There was no significant difference between MPV values of non-exacerbation period and control group (p>0,05).Mean platelet volumes during acute exacerbation were significantly lower when compared with the values of non-exacerbation period and controls (p= 0,02 and p= 0,01 respectively). MPV and platelet counts (r = -0,502, p= 0,01) as well as leucocyte count and hemoglobin levels were inversely correlated with each other in exacerbation period (r= -439, p= 0.00). Mean platelet volume measured at during acute exacerbation were significantly decreased in children with bronchiectasis. With the result of present study, we suggest that MPV might be used as a predictor marker for diagnosis of acute exacerbations in children with bronchiectasis.

Evaluation of Platelet counts and its Indices in Various Clinical Conditions using Automated Hematology Analyzer in a Tertiary care Hospital

“…[20] Larger platelets reflect greater content of granules and imply greater efficiency in its hemostatic and pro-inflammatory function. [21] Accordingly, cases with fever and bronchiectasis showed raised MPV & PDW in this study. It is a known fact that bronchiectasis is a parenchymal lung disease that develops as a result of chronic inflammation and recurrent pulmonary infec tions.…”

“…[3,5,21] Platelet indices in cardiac and neurological diseases: Raised MPV is proved to be an independent risk factor for cardio and cerebrovascular diseases in many studies. [1,3] But the present study did not show raised levels in patients with heart diseases or stroke, probably because of the treatment with no thrombotic risk.…”

Nötrofil- lenfosit oranı ve trombosit- lenfosit oranlarının çocuklardaki kistik fibroz dışı bronşektazinin akut alevlenmesinde potansiyel biyolojik gösterge olarak değerlendirmesi

“…The MPV was also lower in patients with stable-phase COPD compared with the control subjects. Uysal et al [23] compared the MPV values in 81 children with BE to those of healthy control subjects. The MPV values were similar for steady-state patients, whereas a significant difference was observed during exacerbation periods.…”

Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children?

“…In contrast, in the study of Uysal et al . [ 18 ] evaluating children with BE, MPV levels in the acute exacerbation period were found to be significantly lower when compared to the non-exacerbation period and the control group. In asthmatic children, as another chronic airway disease, Tuncel et al .…”

“…Different results in various studies may result from methodological changes. Also, MPV levels may be influenced by the method of blood sampling, care of blood samples, time between sampling and analysing, and the drugs used by the cases [ 18 ]. In our study, platelet counts in the acute exacerbation and non-exacerbation periods were significantly higher than in the control group.…”