Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children?

Nacaroğlu, Hikmet Tekin; Erdem, Semiha Bahçeci; Karaman, Sait; Yazıcı, Selçuk; Can, Demet

doi:10.5114/ceji.2017.72808

Cited by 18 publications

(18 citation statements)

References 27 publications

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“…11,24 The studies showed that PLR was more valuable than NLR in chronic inflammation, and it has been emphasized that PLR is an important inflammation marker. 9,25 Furthermore, there are also studies suggesting that PLR is a predictive marker in nasal polyposis cases. 12 Considering that another topic in ACP etiology is chronic sinusitis and inflammation, there may be changes in the inflammatory blood parameters of these patients.…”

Section: Discussionmentioning

confidence: 99%

“…8 Recently, there are studies in the literature showing that hemogram parameters are associated with the severity of the disease and recurrence in chronic inflammatory diseases. 9,10 Especially, the parameters correlated with the severity of systemic inflammation, such as the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), have also been shown to increase in cases of nasal polyposis. 11 Moreover, there are also studies suggesting that these parameters may be considered as an indicator for recurrence in cases of nasal polyposis.…”

Section: Introductionmentioning

confidence: 99%

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Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Korkmaz

Çelik

Turan

et al. 2020

Int Arch Otorhinolaryngol

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Introduction There are no definitive parameters to guide the etiology and severity of pediatric antrochoanal polyps. Objective The aim of our study is to compare the values of blood cell distribution parameters in cases of pediatric antrochoanal polyps (ACPs) with those of the control group. These values may be guiding parameters in determining the etiology of ACPs and evaluating the severity of the disease and the risk of recurrence. Methods Blood count values of patients operated for pediatric ACPs were retrospectively analyzed and compared with the data of the control group with the same age and gender distribution. The ACPs group was divided into subgroups in terms of inflammation, severity, and recurrence, and these subgroups were statistically compared as well. Results When the ACP patient group and the control group were compared, there was no statistically significant difference between the two groups. When we compared the patients considering the CT findings, there was a statistically significant difference between the stage III patients and the control group in terms of mean platelet volume (MPV) and platelet-to-lymphocyte ratio (PLR) values (p < 0.05 in both). Similarly, the MPV and PLR values were significantly higher in the recurrence patient group than in the control group. (p < 0.05 in both). Conclusion As a result of the data obtained, it can be suggested that inflammatory parameters in pediatric cases of ACPs vary in terms of recurrence and the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Korkmaz

Çelik

Turan

et al. 2020

Int Arch Otorhinolaryngol

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“…MPV is an easily available and economical test and associated with thrombocyte activation in inflammatory conditions, however, contradictory results for MPV have been reported [29][30][31]7 . In the present study there was no relationship between MPV and severity of snake envenomation.…”

Section: Discussionmentioning

confidence: 99%

“…It is a new biomarker of inflammation and can be used as an indicator and prognostic marker of inflammation. The neutrophilto-lymphocyte ratio (NLR) is a useful marker that predicts disease progression and mortality in inflammatory disease [5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

The relationship between neutrophil lymphocyte ratio and clinical outcomes after snakebite in pediatric patients

Aslan

Yıldızdaş

Horoz

et al. 2019

Cukurova Medical Journal

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Öz Purpose: Snake venom has serious cardiotoxic, neurotoxic, nephrotoxic effects. The neutrophil-tolymphocyte ratio (NLR) is a new biomarker of inflammation and can be used as an indicator and prognositic marker of inflammation. In this study we aimed to analyze the association with clinical outcomes of pediatric patients with snakebite envenomation, and NLR. Materials and Methods: A total of 61 pediatric patients with snakebite who admitted to a tertiary university hospital and a children's hospital between July 2012 and July 2017 were included in the study. Demographic features, clinical findings and complications of snakebite, length of stay in hospital, NLR at admission (NLR1), and NLR at the twelfth hour (NLR2) and NLR at the discharge (NLR3) and mean platelet volume (MPV) were retrospectively reviewed and recorded. Results: There was a positive correlation between NLR1 and the length of hospital stay. We found that as the level of NLR1 increased, the length of hospitalization was prolonged. NLR1 level increased as the disease stage progressed, but it was not statistically significant. Our study showed that when the severity of the illness increased, the length of hospital stay was significantly prolonged. Conclusion: The study revealed a positive correlation with NLR and severity of the illness. We claim that NLR at admission can be a useful marker for predicting severe clinical course and prolonged hospital length of stay for pediatric patients with snake envenomation.

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“…[7] The same was stated in Turkey in 2015 where the neutrophil lymphocyte ratio could be used as an inammatory biomarker in acute exacerbation of bronchiectasis in children due to the physiological response of leukocyte circulation in the human body due to increased neutrophils and decreased lymphocytes. [8] Increased neutrophils occur during systemic inammation caused by delayed apoptosis and stem cell stimulation by growth hormone and decreased lymphocytes due to redistribution of lymphocytes to the lymphatic system accompanied by accelerated apoptosis. [7,[9][10] Research that assesses NLR begins in adults but still few in children where several studies report that an increase in NLR is associated with poor prognosis and ideal cut-off still varies with grades 3 to 5.4.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Lymphocytes Ratio as a Predictor of Bacteremia In Children

Lubis

Pasaribu

et al. 2020

Global Journal for Research Analysis

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Bacterial infections are an important problem in the world. Early and accurate diagnosis to detect infection is very important in order to reduce mortality. Many bacterial infections that cause leukocytes are circulating and are characterized by increased neutrophils and decreased lymphocytes, this is caused by the inammatory process. The neutrophil lymphocyte ratio (NLR) is one of the infection markers currently being investigated because it is easy to do, simple with relatively low cost so that it can be used in daily practice. Research with a cross-sectional retrospective design on children performed blood culture at H. Adam Malik Hospital in 2017. Sampling was done in total population and a sample of 506 children who met the inclusion and exclusion criteria was obtained. Data analysis used the chai squared test (p <0.05). This study looked at the 5 most bacteria, namely Klebsiella pneumonia, Acinetobacter baumanii, Staphylococcus aureus, Escherichia coli, Staphylococcus haemolyticus. The neutrophil lymphocyte ratio is better for determining bacteremia with sensitivity of 80.5%, specicity of 26.9%, positive predictive value of 33% and negative predictive value of 74% and cut off 1.3 but cannot be used as a guide because the relationship between blood culture and NLR is not signicant with (p=0.1) and (OR=1.4)

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Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children?

Cited by 18 publications

References 27 publications

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

The relationship between neutrophil lymphocyte ratio and clinical outcomes after snakebite in pediatric patients

Neutrophil Lymphocytes Ratio as a Predictor of Bacteremia In Children

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