Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac

Mali, Kailas K.; Dhawale, Shashikant C.; Dias, Remeth J.; Havaldar, Vijay D.; Kavitake, Pankaj R

doi:10.12991/mpj.2017.20

Cited by 19 publications

(10 citation statements)

References 32 publications

(67 reference statements)

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“…TG is composed of (1→4)-β-D-glucan back-bone substituted with side chains of α-D-xylopyranose and β-D-galactopyranosyl(1→2)-α-D-xylopyranose linked (1→6) to glucose residues [20] . It has been used in the development of various drug delivery systems due to its hydrophilic and bioadhesive properties [21][22][23][24][25][26][27] . Although TG shows presence of non-sterically hindered hydroxyl groups, very few reports mentioned the use of pure TG in chemically crosslinked hydrogels [28] .…”

Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

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Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

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Section: Research Papermentioning

confidence: 99%

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Mali¹,

Dhawale²,

Dias³

et al. 2018

pharmaceutical-sciences

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“…[17] Tamarind polysaccharide is promising excipient, which is being used and investigated for the preparation of various dosage forms. [15,[18][19][20][21][22] The presence of hydroxyl groups in TG makes it suitable for the preparation of physically [23] or chemically [24] cross-linked hydrogels.…”

Section: Research Articlementioning

confidence: 99%

“…An increase in "n" value from HD1 to HD3 suggests an increase in drug hydrogel interaction due to TG. [22] Furthermore, an increase in the concentration of crosslinker (HD1, HD4, and HD5) increases the "n" value which indicates increase in the interaction of drug and hydrogel dressing.…”

Section: In Vitro Releasementioning

confidence: 99%

Untitled

Mali¹

2018

AJP

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Aim: The objective of this study was to develop and evaluate carboxymethylcellulose (CMC) and tamarind gum (TG)-based citric acid cross-linked vancomycin-loaded hydrogel dressing for wound healing. Materials and Methods: CMC and TG are known for its biocompatibility and biodegradability and hence selected for preparation of hydrogel dressings. The hydrogel films were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid-state 13 C-nuclear magnetic resonance (13 C-NMR) spectroscopy, differential scanning calorimeter (DSC), and scanning electron microscopy (SEM). The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Vancomycin hydrochloride was loaded into hydrogels films and drug release was studied in the phosphate buffer pH 7.4. The hemolysis assay was used to study the biocompatibility of hydrogel films. The wound healing activity of optimized hydrogel film was studied in the albino mice of either sex. Results and Discussion: The results of ATR-FTIR, solid-state 13 C-NMR, DSC, and SEM confirmed the formation of citric acid cross-linked hydrogel films. The total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of cross-linker was increased. The prepared hydrogel dressing showed pH-dependent swelling and swelling was decreased significantly with increase in the concentration of TG and cross-linker. Optimized hydrogel dressing batch HD1 exhibited highest drug loading with non-Fickian drug release. Hydrogel dressings were found to be hemocompatible and exhibited wound healing activity in mice. Conclusion: It can be concluded that the citric acid cross-linked polysaccharide-based hydrogel dressings have potential application in the development of topical drug delivery systems for treatment of the wound.

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“…Acyclovir [101] IPNs Ionotropic gelation CMTG-SA (CaCl 2 ) Release controlling agent NA Aceclofenac [103] IPNs covalent cross linking CMTG-CH Release retardant NA TG-tamarind gum; SA-sodium alginate; CH-chitosan; GA-glutaraldehyde; CMTG-carboxymethyl tamarind gum; NA-not applicable…”

Section: Tg-ch (Ga)mentioning

confidence: 99%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac

Cited by 19 publications

References 32 publications

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Untitled

Delivery of drugs using tamarind gum and modified tamarind gum: A review

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