Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery

Abstract

Mali et al.: Carboxymethyl cellulose-based hydrogel films for drug deliveryThe objective of this study was to synthesize and characterize citric acid crosslinked hydrogel films of carboxymethyl cellulose-tamarind gum for topical drug delivery. The hydrogel films were characterized by attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance spectroscopy and differential scanning calorimeter. The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Moxifloxacin hydrochloride was loaded into these hydrogel films and drug release was monitored in the phosphate buffer pH 7.4. Haemolysis assay was used to study biocompatibility of hydrogel films. Results of the attenuated total reflectance-Fourier-transform infrared spectroscopy, solid-state 13 C-nuclear magnetic resonance and differential scanning calorimeter confirmed the formation of citric acid-crosslinked hydrogel films. Total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of citric acid was increased. In contrast, swelling of hydrogel film was found to be decreased with increase in polymer ratio and amount of citric acid. Batch B1 showed highest drug loading with non-Fickian release mechanism. All remaining batches showed nonFickian release behavior with diffusion coefficient greater than 0.5. Results of haemolysis assay indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum hydrogels were safe to be used in drug delivery. These results indicated that the citric acid crosslinked carboxymethyl cellulose-tamarind gum composite hydrogel film has the potential to be used in topical novel drug delivery systems.

Swelling Kinetics and Corneal Hydration Level of Kaolinin-HPMC Hydrogel Film

“…Then the samples were removed at predetermined time intervals up to 6 h from buffer and dabbed with a filter paper to remove excess water. Films were reweighed (W s ) and swelling content (g/g) [10,11] was calculated using the Eqn., S=W s -W 0 / W 0 . Where S is the swelling content (g/g) of film, W s is the final weight of swollen film at time t, and W o is the initial weight of the dry film.…”

Delivery of drugs using tamarind gum and modified tamarind gum: A review

“…Moxifloxacin [107] Hydrogel film Chemical crosslinking TG-CMC (CA) Matrix former NA Ciprofloxacin [106] Phase separated hydrogels Solution casting, Covalent crosslinking TG-gelatin CMTG-gelatin (GA) Mucoadhesive,Vehicle for enteric drug delivery NA Metronidazole [108] Cryogel Physical crosslinking CMTG-PVA Release controlling agent NA Moxifloxacin [54] Hydrogel film Chemical crosslinking CMTG Matrix former NA Aspirin [74] Hydrogel tablet Microwave assisted grafting, Wet granulation TKP-g-PAM Matrix for pH dependent release NA NS [109] Hydrogel Grafting CMTG-HEMA Matrix for Bone tissue engineering NA NS [110] Hydrogel copolymerization CMTG-g-Polyacrylonitrile adsorbant NA TG-tamarind gum; CA-citric acid; CMTG-carboxymethyl tamarind gum; CMC-carboxymethylcellulose; GA-glutaraldehyde; PVA-polyvinyl alcohol; NAnot applicable; NS-not specified…”

A Novel Hydrogel Based on Renewable Materials for Agricultural Application

“…However, the majority of commercially available hydrogels are nonbiodegradable synthetic polymers based on acrylates, which degrade slowly; hence, they have been deemed potential pollutants of soil [7]. A great deal of recent research has focused on devising polymeric absorbent materials that are environmentally friendly, founded upon renewable resources as opposed to synthetic hydrogels of petroleum origin [8][9][10].…”

“…The high absorption, sensitivity to pH, and ionic strength it demonstrates mark it out as an ideal material for preparing hydrogels. When CMCNa is used alone, though, the resultant hydrogels show poor strength, as intramolecular cross-links are formed instead of intermolecular ones [8]. As a consequence, another cellulose derivative-hydroxyethylcellulose (HEC)-was applied in combination with CMCNa to improve such intermolecular cross-linking and stabilize the polymer structure [2,15].…”

“…As a consequence, another cellulose derivative-hydroxyethylcellulose (HEC)-was applied in combination with CMCNa to improve such intermolecular cross-linking and stabilize the polymer structure [2,15]. This type of CMCNa/HEC binary system has been featured in several papers in the literature, wherein swelling properties were reported as similar to conventional acrylate-originating products [8,[16][17][18].…”