Interoceptive Stimulus Effects of Drugs of Abuse

Thompson, Brady M.; Bevins, Rick A.; Murray, Jennifer E.

doi:10.1016/b978-0-12-812202-0.00007-5

Cited by 7 publications

(12 citation statements)

References 139 publications

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“…It is possible that the large individual differences observed in IAcc change reflect the effects on interoception participants usually experience after drinking. If across their history of repeated alcohol consumption, participants experience a similar interoceptive effect, those interoceptive experiences could act as unconditioned stimuli shaping future expectancies through classical conditioning mechanisms 34,35 . This latter hypothesis reconciles our findings that IAcc positively correlates with positive mood changes after alcohol administration, implying that changes in mood could participate in learning mechanisms shaping future expectancies.…”

Section: Discussionsupporting

confidence: 82%

“…Alcohol expectancies are shaped in part by the previous experience of substance effects, 32 as positive substance effects shape future positive expectancies 33 . Interoceptive signals are posited to participate in associative learning processes through their support of a hedonic and incentive signature of alcohol effects 21,34 . Within this learning framework, 35 it is possible that alcohol expectancies are shaped not only by previous social or cognitive experiences but also by interoceptive experiences after alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

“…33 Interoceptive signals are posited to participate in associative learning processes through their support of a hedonic and incentive signature of alcohol effects. 21,34 Within this learning framework, 35 it is possible that alcohol expectancies are shaped not only by previous social or cognitive experiences but also by interoceptive experiences after alcohol consumption. Thus, in this report, we examine whether alcohol expectancies correlate with changes in interoceptive ability following alcohol consumption.…”

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confidence: 99%

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Changes in interoception after alcohol administration correlate with expectancies and subjective effects

et al. 2021

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Interoceptive signals give rise to subjective feeling states that can drive motivational and behavioural responses. In the context of alcohol use behaviours, interoceptive signals may shape subjective alcohol experiences and thereby support biobehavioural mechanisms of drinking behaviour change. This study examined the acute effects of alcohol on participants' interoceptive abilities and determined whether pharmacologically induced changes in heart beat detection correlate with subjective alcohol effects, craving and expectancies. Participants completed a two-session, double-blind placebo controlled experiment (n = 27). Participants consumed a beverage containing 0.4 g/kg of alcohol or a placebo. They also completed measurements of alcohol expectancies at baseline, and alcohol-induced changes in mood, craving and lightheadedness. Interoceptive ability was measured using the heartbeat discrimination task prior to and following beverage administration, yielding indices of interoceptive accuracy, confidence and meta-cognition. Alcohol administration increased interoceptive accuracy compared with baseline and placebo; and those changes in interoception negatively correlated with negative alcohol expectancies. Further, changes in interoception positively correlated with perceived light-headedness and positive mood after alcohol administration, whereas null effects were found for craving. In the placebo condition, null results were obtained. Alcohol is well established to change bodily states, and here, we find that the extent to which alcohol increases participants' sensitivity to bodily states correlates with their subjective drinking experiences. This was observed in relation to mood, light-headedness and prospective alcohol expectancies. We posit that over successive alcohol experiences, changes in bodily states may feed into the development of alcohol expectancies that could in turn predict future drinking behaviours.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Changes in interoception after alcohol administration correlate with expectancies and subjective effects

et al. 2021

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“…However, (for example, the blood sugar level in the circulation when hunger does not necessarily decrease), but both can be stimulated by environmental stimuli (such as stimulated by signals that indicate availability). A study also shows that craving and relapsing do not depend on direct physiological drug effects ( 119 ). Furthermore, the ecological validity of the cue-induced paradigm is poor, as the subject may be affected by response tendency and social expectations, which may influence the correlation between brain activation and craving scores.…”

Section: Discussionmentioning

confidence: 99%

Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA

Zhang

Liu

et al. 2022

Front. Psychiatry

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Abuses of most illegal drugs, including methamphetamine, marijuana, cocaine, heroin, and polydrug, are usually in conjunction with alcohol and tobacco. There are similarities and associations between the behavior, gene, and neurophysiology of such abusers, but the neural overlaps of their cue-reactivity and the correlation of neural overlap with drug craving still needs to be further explored. In this study, an Activation Likelihood Estimation (ALE) was performed on brain activation under legal (tobacco, alcohol) and illegal drug cues, for identifying the similarities in brain functions between different craving states. A Comprehensive meta-analysis (CMA) on the correlation coefficient between brain activation and craving scores in the selected literatures with subjective craving reports explained the degree of the craving via brain imaging results. In ALE, co-activation areas of the three cue-reactivity (posterior cingulate, caudate, and thalamus) suggest that the three cue-reactivity may all arouse drug-use identity which is a predictor of relapse and generation of conditioned reflexes under reward memory, thus leading to illegal drug relapses. In CMA, the brain activation was significantly correlated with subjective craving, with a correlation coefficient of 0.222. The neural overlap of tobacco, alcohol and most of the prevalent illegal drug cues not only further helps us understand the neural mechanism of substance co-abuse and relapse, but also provides implications to detoxification. Furthermore, the correlation between brain activation and craving is low, suggesting the accuracy of craving-based quantitative evaluation by neuroimaging remains unclear.

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“…Alternatively, exaggerated interoceptive responses to negative or uncomfortable stimuli (e.g., increased heart rate) may lead an individual to seek out substances such as alcohol, opioids, or benzodiazepines to alleviate these sensations. Interoception is also linked to drug craving, wherein the anterior INS directs attention away from cognitive tasks and towards interoceptive stimuli, such as the bodily effects of substance use, and cues cravings to use in the future [ 29 ]. Below, we review the literature for evidence of interoceptive dysfunction in iSUD.…”

Section: The Role Of Interoception In Sudmentioning

confidence: 99%

Mindfulness-Based Interventions for the Treatment of Aberrant Interoceptive Processing in Substance Use Disorders

et al. 2022

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Altered interoception, or the processing of bodily signals, has been argued to play a role in the development and maintenance of substance use disorders (SUD). Therefore, interoceptive interventions focusing on bodily awareness, such as mindfulness meditation, may improve treatment outcomes for individuals with SUD. Here we review: (1) subjective, behavioral and brain evidence for altered interoceptive processing in SUD, focusing on insular and anterior cingulate cortices (INS, ACC), key regions for interoceptive processing; (2) research highlighting links between mindfulness and brain function; and (3) extant brain research investigating mindfulness-based interventions in SUD. SUD tend to be characterized by heightened INS and ACC responses to drug cues but blunted interoceptive awareness and attenuated INS and ACC responses during tasks involving bodily attention and/or perturbations. In contrast, mindfulness interventions in healthy individuals are linked to enhanced INS and ACC responses and heightened interoceptive awareness. It is crucial for future research to identify: (1) whether mindfulness-based treatments are efficacious across substance classes; (2) what particular approaches and dosages show the largest effect sizes in enhancing INS and ACC function to non-drug stimuli and reducing responsivity to substance cues, thereby improving SUD treatment outcomes (reducing drug craving and relapse).

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Interoceptive Stimulus Effects of Drugs of Abuse

Cited by 7 publications

References 139 publications

Changes in interoception after alcohol administration correlate with expectancies and subjective effects

Changes in interoception after alcohol administration correlate with expectancies and subjective effects

Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA

Mindfulness-Based Interventions for the Treatment of Aberrant Interoceptive Processing in Substance Use Disorders

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