Internal glow discharge-fourier transform ion cyclotron resonance mass spectrometry

Goodner, Kevin; Milgram, K. Eric; Watson, Clifford H.; Eyler, John R.; Dejsupa, C.; Barshick, C. M.

doi:10.1016/1044-0305(96)00025-6

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…The high resolving power of FTICR has also been demonstrated in inorganic mass spectrometry via the coupling of plasma ion sources, such as glow discharge − and inductively coupled plasma . Figure , for example, shows a resolving power of 1.7 × 10 6 for 58 Fe + formed via glow discharge ionization using a 7 T FTICR spectrometer .…”

Section: Fourier Transform Ion Cyclotron Resonance Mass Spectrometrymentioning

confidence: 93%

“…130 Easterling et al recently demonstrated that mass measurement accuracies on the order of 2 ppm can be achieved routinely on ions derived from MALDI despite the relatively poor shot-to-shot reproducibility of the number of ions. 132 The high resolving power of FTICR has also been demonstrated in inorganic mass spectrometry via the coupling of plasma ion sources, such as glow discharge [133][134][135][136][137] and inductively coupled plasma. 138 Figure 14, for example, shows a resolving power of 1.7 × 10 6 for 58 Fe + formed via glow discharge ionization using a 7 T FTICR spectrometer.…”

Section: Fourier Transform Ion Cyclotron Resonance Mass Spectrometrymentioning

confidence: 99%

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Mass Analysis at the Advent of the 21st Century

2001

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There have been many new and exciting developments in mass spectrometer systems in recent years. Many of these developments are being driven by challenges presented by molecular biology. The activity is fueled by resources being devoted to drug development, for example, and other medically and biologically related activities. Progress in these applications will be accelerated by improved sensitivity, specificity, and speed. In mass spectrometry, this translates to greater mass resolving power, mass accuracy, mass-to-charge range, efficiency, and speed. It is safe to say that the demands resulting from current analytical needs are likely to be met to varying degrees but probably not by a single analyzer technology or hybrid instrument. On-line and/or off-line separations and manipulations combined with mass spectrometry will also play increasingly important roles. For any analyzer, or combination of analyzers, to become widely used it must have an important application for which its figures of merit are best suited, relative to competing approaches. The relative cost of competing technologies is also an important factor. The mass filter has seen so much use in the past 30 years because its characteristics best fit a wide range of applications. As an example, biological applications, which are currently driving many instrument development activities in mass spectrometry, demand more information, of higher quality, from less material, faster, and at lower cost. Which technologies will dominate biological applications in the coming years is open to speculation. However, in considering the relative merits of today's dominant mass analyzers, areas of opportunity for improvement are apparent. Furthermore, new and more demanding measurement needs are constantly being recognized that will continue to exercise the creativity of the mass spectrometry community.

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Section: Fourier Transform Ion Cyclotron Resonance Mass Spectrometrymentioning

confidence: 93%

Section: Fourier Transform Ion Cyclotron Resonance Mass Spectrometrymentioning

confidence: 99%

Mass Analysis at the Advent of the 21st Century

2001

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“…[18][19][20][21][22][23][24] The ion/ molecule chemistry discussed in this work could also be used to advantage in Fourier transform ion cyclotron resonance instruments which incorporate various atomic ion sources. [25][26][27][28] For example, selective ion/ molecule chemistry could be used to shift the m/z ratio of an interferent species so that selective and efficient removal from the trap could be effected prior to mass analysis.…”

Section: 15mentioning

confidence: 99%

Beneficial Ion/Molecule Reactions in Elemental Mass Spectrometry

Eiden

Barinaga

Koppenaal

1997

Rapid Commun. Mass Spectrom.

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A plasma source ion trap (PSIT) mass spectrometer has been modified to incorporate a radiofrequency octopole ion guide/collision cell between the ion source and the mass spectrometer. This modification allows ions sampled from the plasma to undergo reactions prior to mass spectrometric analysis. This capability can obviate the need for chemical or chromatographic separation of the sample, remove mass spectral intereferences and enable formation of analytically useful molecular ions. Distinct reaction chemistries can be utilized in the octopole and/or ion trap. Performance of the instrument is dramatically improved if hydrogen gas is introduced into the octopole; molecular hydrogen reacts with Ar + and certain other plasma ions, greatly reduces their intensities, and cools and focuses the ion beam prior to its injection into the ion trap.

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“…19 The trademark of Fourier trans-focal point form ion cyclotron resonance (FT-ICR) mass spectrometry remains its ability to provide extremely high resolving power. Goodner et al 25 and Marcus et al 26 have combined FT-ICR instruments with GD sources, and initial designs of an FT-ICR instrument coupled to the ICP have been presented. 27,28 When coupled to a GD source, the FT-ICR allows both molecular and atomic isobaric overlaps to be separated easily, with recently demonstrated resolving powers as high as 1,700,000.…”

Section: Alternative Mass Analyzers For Icpmsmentioning

confidence: 99%