Time-of-Flight Mass Spectrometry for Elemental Analysis

Mahoney, Patrick P.; Ray, Steven J.; Hieftje, Gary M.

doi:10.1366/0003702971938759

Cited by 80 publications

(80 citation statements)

References 61 publications

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“…[137][138][139][140][141] Detailed reviews of the development and analytical performance of TOF-MS combined with ICP ion source have been presented. [142][143][144][145] Attempts to couple TOF-MS to a microwave induced plasma (MIP) for elemental analysis have also been described.…”

Section: An Overview Of Analytical Applications Of Tof-ms Analyzersmentioning

confidence: 99%

An Overview of Analytical Applications of Time of Flight-Mass Spectrometric (TOF-MS) Analyzers and an Inductively Coupled Plasma-TOF-MS Technique

Balcerzak

2003

ANAL. SCI.

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Section: An Overview Of Analytical Applications Of Tof-ms Analyzersmentioning

confidence: 99%

An Overview of Analytical Applications of Time of Flight-Mass Spectrometric (TOF-MS) Analyzers and an Inductively Coupled Plasma-TOF-MS Technique

Balcerzak

2003

ANAL. SCI.

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“…With the notable exception of ICP-TOFMS, all multi-channel ICP-MS instruments are assumed to provide 100% duty cycle. For ICP-TOFMS, duty cycle is inherently limited [7].…”

Section: Duty Cycle and Scanning Ratesmentioning

confidence: 99%

“…Consequently, a single-channel system cannot ratio consecutive m/z values as precisely as can a multichannel system. For a multichannel system, counting or Poisson statistics limits precision [21] because multiplicative source noise can be overcome through isotope-ratio [7] or internal-standardization techniques. For the comparisons here, noise sources are separated into two categories: 1) noise that is multiplicative in nature and 2) noise dictated by Poisson statistics.…”

Section: Signal Noise and Precisionmentioning

confidence: 99%

“…Simulated single-channel results will include one of two different multiplicative source-noise levels, 1.0% and 0.2% RSD, in addition to counting statistics-related noise. Only noise due to counting statistics will be considered for theoretical multichannel data since multiplicative noise can then be overcome by ratioing [7]. A trio of isotope pairs, 107,109 Ag, 20,22 Ne, and 12,13 C, chosen because of their approximate abundance ratios, 1, 10, and 100 [22], respectively, will be used to generate ratio precision values.…”

Section: Signal Noise and Precisionmentioning

confidence: 99%

“…As cited earlier in the text, ICP-TOFMS is a notable exception in this comparison between the duty cycles of sequential and simultaneous instruments. While the duty cycle of an ICP-TOFMS instrument is independent of the number of channels of interest, it is inherently limited in duty cycle to a value well below 100% (5-10% is typical) [7]. The fraction of analyte that is wasted by the scanning system increases with the number of channels and equals 1-DC.…”

Section: Duty Cyclementioning

confidence: 99%

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Simultaneous or scanning data acquisition? A theoretical comparison relevant to inductively coupled plasma sector-field mass spectrometers

Solyom

Hieftje

2003

J. Am. Soc. Mass Spectrom.

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The benefits of simultaneous multichannel detection over single-channel scanning detection are well established in analytical chemistry. Multichannel detection increases duty cycle, which leads to enhanced sensitivity, detection limits, and reduced analysis time. Also, multichannel detection used with either isotope-ratio or internal-standard techniques provides a mechanism to reduce the effect of multiplicative or flicker noise prevalent in plasma sources. An additional benefit of simultaneous detection is superior analysis of short-lived transient signals. Presented here is a theoretical comparison between simultaneous/continuous multichannel acquisition and single-channel scanning acquisition. To conduct this comparison, reported sensitivity, single-channel precision, and background values for commercial inductively coupled plasma sector-field mass spectrometers (ICP-SFMS) are used to generate theoretical figures of merit for both acquisition methods. Among the figures of merit that will be considered are detection limits, precision, and analysis time, particularly for multi-element or multi-isotope analysis. (J Am Soc Mass Spectrom 2003, 14, 227-235)

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