Intermolecular Interaction between a Synthetic Pseudoceramide and a Sterol-Combined Fatty Acid

Precipitation of a Poorly Soluble Model Drug during In Vitro Lipolysis: Characterization and Dissolution of the Precipitate

“…Similar periodicity of the lamellar phase diffractions was observed in phospholipids and ethylene oxide (surfactant) system 31. XRPD patterns of both pellets also showed peaks at the d ‐spacing of 4.4 Å´ which can be attributed to the latteral packing of the hydrocarbon chains in the lamellar structure, indicating some degree of crystallinity in the sample 32–34. Overall, the XRPD measurements suggest the presence of lamellar phases (liquid crystalline and/or crystalline) of calcium soaps in the lipolysis precipitates.…”

On the effects of topical synthetic pseudoceramides: Comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides

“…For example, when present as the dominant species in a 3:1:1 molar ratio, they accelerate barrier recovery after acute abrogation in comparison to vehicletreated sites [4,14]. Two pseudo-Cer, i.e., N-(3-hexadecyloxy-2-hydroxypropyl)-N-2-hydroxyethylhexadecanamide (PC-104) and a similar structural compound, N-(2-hydroxyethyl)-2-pentadecanolylhexadecanamide (Bio391), can form lamellar/multilamellar structures in vitro with cholesterol and free fatty acids [15][16][17]. Accordingly, the cutaneous symptoms of atopic dermatitis appear to improve in patients treated with pseudo-Cer (PC-104 and others)-containing mixtures [4,18,19].…”

Effect of UVA or UVB Irradiation on Cutaneous Lipids in Films or in Solution

“…This technique is classically used to study the conformational evolution of lipid organization through the study of the variation of different band frequencies, describing, on the one hand the carbon chain behavior, and on the other hand the polar headgroup interaction (11,12). Other techniques such as X‐ray diffraction (13) or differential scanning calorimetry (14) made it possible previously to establish the different lipid states.…”