This chapter traces an overview of the evolution of the research on Intermedial Studies in the last two decades. It expands the research presented in the InTech volume Comparative Literature. Interdisciplinary Considerations, in a chapter entitled ‘Intermedial Comparative Literature: from the Sister-Arts Debate to the twentieth century Avant-gardes’. The literature review offers a description of the major interdisciplinary contributions that have shaped the field of Intermedial Studies, with areas such as media and communication studies, art history, and the visual arts, including theater, dance and performance, sequential art (comics, graphic novels), photography, radio, film studies, electronic literature, videogames and Artificial Intelligence.