Interleukin-6 (IL-6) production and cell growth of cultured human ameningiomas:- Interactions with interleukin-1β (IL-1β) and interleukin-4 (IL-4) in vitro

Effects of interleukin-1 and dexamethasone on interleukin-6 production and growth in human meningiomas

“…Such 17,18 and we confirm this, not only with respect to the IL-6 growth response but also with other parameters. There were significant differences in the secretory and growth responses to IL-1 and dexamethasone between these tumours.…”

“…13,[15][16][17] The cytokine interleukin-6 (IL-6) is synthesized and secreted by meningioma cells. 18,19 Expression of mRNA of other cytokines, IL-1 , IL-3, IL-8, TNF (tumour necrosis factor-) and TGF 1, 2, and 3 have been identified in meningioma tissue, 20 but apart from IL-6 and TGF, no effect on growth has been demonstrated. Reports on the effects of IL-6 on the growth of meningioma cells are diverse, with Boyle-Walsh et al 18 demonstrating a stimulation of growth in 60 per cent of tumours, whereas Todo et al 19 found that IL-6 inhibited proliferation.…”

“…18,19 Expression of mRNA of other cytokines, IL-1 , IL-3, IL-8, TNF (tumour necrosis factor-) and TGF 1, 2, and 3 have been identified in meningioma tissue, 20 but apart from IL-6 and TGF, no effect on growth has been demonstrated. Reports on the effects of IL-6 on the growth of meningioma cells are diverse, with Boyle-Walsh et al 18 demonstrating a stimulation of growth in 60 per cent of tumours, whereas Todo et al 19 found that IL-6 inhibited proliferation. The effect of IL-6 on meningioma cell growth is clearly complex; in the first study IL-6 stimulated growth, whereas IL-1 and IL-4, although increasing IL-6 production, resulted in an overall inhibition of growth.…”

“…The effect of IL-6 on meningioma cell growth is clearly complex; in the first study IL-6 stimulated growth, whereas IL-1 and IL-4, although increasing IL-6 production, resulted in an overall inhibition of growth. 18 The reasons for these diverse observations are not apparent, but it has been suggested that they may be due to a concentration-dependent effect of IL-6, with inhibition at low and stimulation at high concentrations. 20 Diverse effects of IL-6 on cell growth have also been found to occur in melanomas 21 and between normal and adenomatous pituitary tissue.…”

A comparative study of cytokine gene transcripts in normal and malignant breast tissue and primary cell cultures derived from the same tissue samples

“…In some models, IL-1 appears to control production of IL-6 (Erroi et aL, 1989;Boyle-Walsh et al, 1994), and in the present study, with only 4 exceptions where IL-1p…”