Interleukin-6 for the diagnosis of ovarian torsion: A systematic review and meta-analysis

Abstract

Ovarian torsion may have significant fertility implications. Interleukin-6 is a pro-inflammatory cytokine, which may act as a helpful diagnostic test. Our objective was to investigate the accuracy of serum interleukin-6 in the diagnosis of ovarian torsion in women with ultrasonographic evidence of an ovarian cyst. An electronic search of published data, unpublished dissertations, theses and conference proceedings was performed. The systematic review involved observational studies. The studies had to provide data to construct 2 × 2 tables. A modified QUADAS tool was used to assess the quality of studies. Sensitivity, specificity, positive and negative predictive value, likelihood ratios and diagnostic odds ratios were calculated. Three studies were identified. Two were included in the meta-analysis. The prevalence of torsion was 30% (21/70). The pooled sensitivity was 85.1% and the pooled specificity was 84.1%. Although further cohort studies would be required, there may be a role for interleukin-6 in the diagnosis of ovarian torsion.

Use of cancer antigen 125, cancer antigen 19‐9, and the neutrophil‐to‐lymphocyte ratio to diagnose mature cystic teratoma with torsion

“…In the present study, white blood cell, neutrophil, and lymphocyte counts were all markedly higher in the torsion group than in the control group. Elevated serum concentrations of interleukin‐6 were previously shown to be associated with the occurrence of ovarian torsion . Cytokines might also function in the elevation of CA125 and the NLR …”

High-sensitivity C-reactive protein as a novel marker in early diagnosis of ovarian torsion: an experimental study

“…Serum D-dimer, ischemia-modified albumin, IL-6, IL-8, TNF-a, and E-selectin, have been investigated as serum markers in patients with ovarian torsion. Among these, elevated IL-6, D-dimer, and ischemia-modified albumin concentrations have been shown to be associated with ovarian torsion [2,[11][12][13][14][15]. Kart et al investigated the diagnostic value of plasma D-dimer level in an experimental rat ovarian torsion model and stated that D-dimer was well correlated with histopathological damage scores of ovarian injury and might be used as a plasma marker in early detection of ovarian torsion [14].…”

“…Christopoulos et al [11] investigated the accuracy of serum interleukin-6 in the diagnosis of ovarian torsion in women with ultrasonographic evidence of an ovarian cyst in a systematic review that involved observational studies. A total of three studies met their inclusion criteria [2,12,13].…”

A new biomarker for the early diagnosis of ovarian torsion: SCUBE-1

“…Several studies have shown that some serum biomarkers, such as serum d-dimer, IL-6, IL-8, tumor necrosis factor-alpha (TNF-α), heat shock protein 70, and ischemia-modified albumin, can play a role in the early detection of OT [ 7 27 28 29 ]. Kart et al [ 29 ] studied the diagnostic value of plasma d-dimer levels in an experimental rat OT model and found a significant correlation between plasma d-dimer levels and the histopathological damage scores of ovarian injuries.…”