Interleukin-6 and ratio of plasma interleukin-6/interleukin-10 as risk factors of symptomatic lumbar osteoarthritis

Abstract

AIMTo determine the role of cartilage oligomeric matrix protein (COMP), interleukin (IL)-6, IL-10 and ratio of IL-6/IL-10 as risk factors of symptomatic lumbar osteoarthritis (OA) in postmenopausal women with estrogen deficiency.METHODSCase-control study had been conducted in Sanglah General Hospital from October 2015 until March 2016. The blood samples were obtained and analyzed by enzyme-linked immunosorbent assay (ELISA).RESULTSFrom 44 pairs of samples which divided into 44 samples as case group and 44 samples as control group showed that high level of COMP in estrogen deficiency postmenopausal women were not at risk (OR = 0.7; 95%CI: 0.261-1.751; P = 0.393) for symptomatic lumbar OA (cut-off point 0.946). Estrogen deficiency in postmenopausal women with the high level of IL-6 had 2.7 times risk (OR = 2.7; 95%CI: 0.991-8.320; P = 0.033) for symptomatic lumbar OA from the low level of IL-6 (cut-off point 2.264). At lower level of IL-10, there was no risk for symptomatic lumbar OA (OR = 0.6; 95%CI: 0.209-1.798; P = 0.345) than with the higher level of IL-10 (cut-off point 6.049). While the high ratio of IL-6/IL-10 level in estrogen deficiency postmenopausal women gave 3.4 times risk (OR = 3.4; 95%CI: 1.204-11.787; P = 0.011) for symptomatic lumbar OA than the low ratio of IL-6/IL-10 level (cut-off point 0.364).CONCLUSIONHigh ratio of IL-6/IL-10 plasma level was the highest risk factor for causing symptomatic lumbar OA in postmenopausal women with estrogen deficiency.

Altered Wnt and NF-<i>κ</i>B Signaling in Facet Joint Osteoarthritis: Insights from RNA Deep Sequencing

“…Osteoarthritis has been recognized as an inflammatory disease since inflammation is implicated in the osteoarthritis pain process and cartilage degradation process (Berenbaum 2013;Rahmati et al 2016). Many inflammatory cytokines and inflammatory mediators, such as interleukin-1, interleukin-6, and tumor necrosis factor, were involved in the pathophysiology of osteoarthritis (Fernandes et al 2002;Akeson and Malemud 2017;Suyasa et al 2017). Anti-inflammatory proteins were also demonstrated to exhibit a favorable role in the treatment of osteoarthritis (van Drumpt et al 2016;Hix et al 2017;Kon et al 2018).…”

Elevated High-Sensitivity C-Reactive Protein And Interleukin-6 Plasma As Risk Factors For Symptomatic Lumbar Osteoarthritis In Postmenopausal Women

“…Despite being a degeneration process, inflammation also plays a role in OA. The inflammatory development that happens in lumbar osteoarthritis involves the role of proinflammatory cytokines, or anti-inflammatory cytokines [ 2 ], [ 4 ].…”

“…The prevalence of osteoarthritis at the age of 50 years both in men and women is relatively similar and increasing in women of over 50 years old. Numerous causes have been proposed, including estrogen alterations that frequently arise in post menopausal women in post-menopausal age [ 1 ], [ 2 ].…”

“…Lumbar osteoarthritis (OA) is a cartilage degeneration involving the narrowing of the intervertebral discs, lumbar vertebral osteophyte, and osteoarthritis of the facet joints [ 2 ], [ 3 ], [ 4 ]. Some suspected causes of lumbar OA include hormonal changes in post menopausal women, including changes in the hormone estrogen, mechanical stress caused by weight gain and ageing process, and inflammatory process.…”

“…Chronic inflammation that occurs in lumbar OA involved the role of cytokines, like interleukin 6 (IL-6), IL-10 and IL-1ra [ 5 ]. According to another study, IL-6 level and IL-6/IL-10 ratio were predictive as the risk of lumbar OA [ 2 ]. An increased level of inflammatory mediators will cause a systemic inflammatory reaction.…”