Toona sinensis modulates autophagy and cytokines in lipopolysaccharide-induced RAW 264.7 macrophages

Kuo, Chun-En; Wu, Shu-Chun; Lee, Chen‐Hsiang; Lai, Yun-Ru; Lu, Cheng-Hsien; Chen, Po‐Cheng; Cheng, Jai-Hong; Tsai, Li-Yu; Yen, Ke-Tien; Yu, Tang

doi:10.1016/j.biopha.2020.110386

Cited by 12 publications

(8 citation statements)

References 49 publications

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“…TSL aqueous extracts increased the level of total GSH and the ratio of GSH/glutathione oxide (GSSG) in RAW264.7 cells treated with LPS but decreased the levels of GSSG, total NO, nitrate, nitrite, MDA and superoxide anion. TSL water extracts reversed the effects of LPS-induced cytokines, including IL-6 and IL-10, to modulate autophagy during inflammation [70]. The adventitious shoot extracts of T. sinensis showed good anti-inflammatory activity on LPS-treated RAW 264.7 cells and Propionibacterium acnes-treated HaCaT cells.…”

Section: Anti-inflammatory Activitymentioning

confidence: 95%

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Zhao,

Li,

Wang

et al. 2024

Molecules

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Toona sinensis (A. Juss.) Roem., which is widely distributed in China, is a homologous plant resource of medicine and food. The leaves, seeds, barks, buds and pericarps of T. sinensis can be used as medicine with traditional efficacy. Due to its extensive use in traditional medicine in the ancient world, the T. sinensis plant has significant development potential. In this review, 206 compounds, including triterpenoids (1–133), sesquiterpenoids (134–135), diterpenoids (136–142), sterols (143–147), phenols (148–167), flavonoids (168–186), phenylpropanoids (187–192) and others (193–206), are isolated from the T. sinensis plant. The mass spectrum cracking laws of representative compounds (64, 128, 129, 154–156, 175, 177, 179 and 183) are reviewed, which are conducive to the discovery of novel active substances. Modern pharmacological studies have shown that T. sinensis extracts and their compounds have antidiabetic, antidiabetic nephropathy, antioxidant, anti-inflammatory, antitumor, hepatoprotective, antiviral, antibacterial, immunopotentiation and other biological activities. The traditional uses, chemical constituents, compound cracking laws and pharmacological activities of different parts of T. sinensis are reviewed, laying the foundation for improving the development and utilization of its medicinal value.

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Section: Anti-inflammatory Activitymentioning

confidence: 95%

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Zhao,

Li,

Wang

et al. 2024

Molecules

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“…For instance, the inhibition of the mTOR signal can cause the limited expression of the downstream protein, P70S6K, which in turn may increase neuronal autophagy ( 73 ). Also, the inhibition of the mTOR phosphorylation promotes LC3-II expression and increases the ratio of LC3-II/LC3-I, which is concomitant with autophagy increased ( 74 ). Although neurons have moderate autophagy in the process of maintaining homeostasis, long-term overactivated autophagy can cause serious damage to neurons.…”

Section: The Mtor Signaling Pathwaymentioning

confidence: 99%

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Wang

Botchway

et al. 2022

Front. Neurol.

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The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress caused by secondary SCI may instigate serious consequences in the event of SCI. The mammalian target of rapamycin (mTOR), as a key signaling molecule, participates in the regulation of inflammation, apoptosis, and autophagy in several processes associated with SCI. Quercetin can reduce the loss of myelin sheath, enhance the ability of antioxidant stress, and promote axonal regeneration. Moreover, quercetin is also a significant player in regulating the mTOR signaling pathway that improves pathological alterations following neuronal injury. Herein, we review the therapeutic effects of quercetin in SCI through its modulation of the mTOR signaling pathway and elaborate on how it can be a potential interventional agent for SCI.

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“…Autophagy selectively degrades cellular components to minimize cell injury [3]. Autophagy is related to inflammation and immunity regulation and has tumor-suppressive properties [51].…”

Section: Intervention Clinical Trialmentioning

confidence: 99%

“…Cancer, in general, develops due to successive mutations in genes, which alter cell morphology and physiology [2]. Oxidative stress leads to inflammation through redox pathways, increasing inflammatory marker circulation [3,4]. The inflammatory response causes tissue injury and DNA damage [3,5].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Mechanisms of Coffee on Prostate Cancer Prevention

Montenegro

Freitas-Silva

Teodoro

2022

BioMed Research International

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Prostate cancer (PCa) is one of the most common types of cancer among men, and coffee is associated with a reduced risk of developing PCa. Therefore, we aim to review possible coffee molecular mechanisms that contribute to PCa prevention. Coffee has an important antioxidant capacity that reduces oxidative stress, leading to a reduced mutation in cells. Beyond direct antioxidant activity, coffee stimulates phase II enzymatic activity, which is related to the detoxification of reactive metabolites. The anti-inflammatory effects of coffee reduce tissue damage related to PCa development. Coffee induces autophagy, regulates the NF-κB pathway, and reduces the expression of iNOS and inflammatory mediators, such as TNF-α, IL-6, IL-8, and CRP. Also, coffee modulates transcriptional factors and pathways. It has been shown that coffee increases testosterone and reduces sex hormone-binding globulin, estrogen, and prostate-specific antigen. Coffee also enhances insulin resistance and glucose metabolism. All these effects may contribute to protection against PCa development.

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Toona sinensis modulates autophagy and cytokines in lipopolysaccharide-induced RAW 264.7 macrophages

Cited by 12 publications

References 49 publications

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Traditional Uses, Chemical Constituents and Pharmacological Activities of the Toona sinensis Plant

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Molecular Mechanisms of Coffee on Prostate Cancer Prevention

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