Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Kazemi, Ahmad; Gorabi, Armita Mahdavi; Forouzesh, Mehdi; Hosseini, Mojgan; Марков, А. В.; Imani, Danyal; Razi, Bahman; Mousavi, Mohammad Javad; Aslani, Saeed; Mikaeili, Haleh

doi:10.1186/s12865-020-00384-7

Cited by 19 publications

(8 citation statements)

References 69 publications

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“…In recent years, much research has been conducted studying the genetic markers of allergic pathology. Research in recent years has identified five DNA loci that are most common in children with CMA [ 17 ]. In particular, the first chromosome contains the filaggrin gene, which is involved in the formation of the protective epithelial barrier.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis that included 55 studies conducted by Kousha et al showed that the CT genotype of the IL-4 T589C locus polymorphism was associated with an increased risk of asthma in the general population, regardless of ethnicity [ 17 ]. It was also found that the AA genotype of the IL-13 R130Q (rs20541) locus polymorphism was significantly more common in children with asthma than in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Matsyura

Беш

Kens

et al. 2022

Life

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Cow’s milk allergy (CMA) is one of the most frequent types of food allergy. The aim of the study was to investigate whether IL-13 R130Q and IL-4 T589C polymorphisms are associated with the risk of CMA in young Ukrainian children. A total of 120 children (age range: 1–3 years) participated in the study and were divided into two groups: CMA (n = 60) and healthy controls (CNT, n = 60). The CMA group had two subgroups: specific oral tolerance induction (SOTI, n = 30) and milk elimination diet (MED, n = 30). The CNT group had two subgroups: positive family history of allergy (+FHA, n = 24) and negative family history of allergy (−FHA, n = 36). In the CMA group, molecular genetic testing of CC, CT, and TT genotypes of single nucleotide IL-4 T589C gene polymorphisms showed significantly higher rates of the CC genotype compared to healthy controls (92.2% vs. 58.8%; p < 0.01). In the CMA group, molecular genetic testing of GG, GA, and AA genotypes of single nucleotide IL-13 R130Q gene polymorphisms showed significantly higher rates of GA and AA polymorphic locus genotypes compared to healthy controls (43.5% vs. 22.4%, p < 0.05 and 8.7% vs. 0%, p < 0.05, respectively). In future studies, the genotypic and allelic distribution of these polymorphic variants will be determined in children with CMA and healthy children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Matsyura

Беш

Kens

et al. 2022

Life

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“…In the disease spectrum of PNV, IL-4 was speci cally associated with the choroidal thickness, and the choroidal thickness was associated with the single nucleotide polymorphism of IL-4-590 (rs2243250), which is a well-recognized allele associated with asthma and rhinitis. 14,15 Earlier, the molecular pathology of nAMD was examined by analyzing the aqueous humor of the patients. Several studies found a signi cant association of in ammatory cytokines with nAMD.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-4 with pachychoroid neovasculopathy

Baba

Koyama

Uotani

et al. 2022

Preprint

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The purpose of this study was to identify inflammatory cytokines that are associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of intracameral cytokines. In eyes with PNV, IL-1α, IL-1β, IL-2, IL-4, IL-10, and VEGF were significantly elevated compared to controls. Logistic regression analysis indicated highest association with pachyvessels was observed for IL-4, IL-2, and IL-1α. In eyes with PNV, IL-4, TNFα, IL-17, IL-2, IL-12, IL-15, IL-5, IL-13, IL-1α, and IL-1β significantly increased choroidal thickness. Highest correlation with choroidal thickness was observed for IL-4. In PNV eyes with polypoidal lesions, the level of IL-4, IL-17, and TNFβ significantly correlated with the number of polypoidal lesions. We determined how the different disease characteristics of PNV were associated with the elevated cytokines. Of all these cytokines, IL-4 contributed significantly to the thickening of the choroidal vessels and to the formation of polypoidal lesions. We conclude that IL-4 is most likely involved in the establishing the clinical characteristics of PNV and polypoidal vascular remodeling. This may help to establish future therapeutic strategy for PNV.

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“…Inflammatory gene-environment interactions in COPD IL13, and CSF2 genes [16] . Numerous reports associated IL4 gene polymorphisms with allergic rhinitis [39] , bronchial asthma [40] , and COPD [41,42] . IL4 is produced by activated immune cells and binds to the IL4 receptor [16] .…”

Section: Global Translational Medicinementioning

confidence: 99%

Gene-gene and gene-environment interactions of the inflammatory gene variants in the development of chronic obstructive pulmonary disease

Korytina¹,

Aznabaeva²,

Nasibullin³

et al. 2022

Global Transl Med

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Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that is characterized by partly reversible airflow limitation, chronic inflammation, fibrosis of small airways, and destruction of lung parenchyma. We aimed to assess the association of the inflammatory gene loci singly and in combinations with COPD in smokers and non-smokers in ethnic Tatar from Russia to evaluate the gene-gene and gene-environment interactions in COPD development. Eleven loci of inflammatory genes, including IL19, IL20, IL24, PPBP, IL4, IL4RA, С5, FAS, FASLG, and TGFb1, were genotyped in 484 smoking COPD patients, 517 healthy smokers, 117 non-smoking COPD patients, and 100 healthy non-smokers. Significant associations with COPD in smokers were identified for IL19 (rs2243193), IL4 (rs2243250), IL4 (rs2070874), and PPBP (rs352010). In non-smokers, associations were established for IL24 (rs291107), IL4 (rs2070874), and PPBP (rs352010). Associations of inflammatory genes loci IL19 (rs2243193), IL4 (rs2070874), TGFb1 (rs1800469), PPBP (rs352010), and FASLG (rs763110) and smoking index were determined. Associations of FAS (rs1800682), FASLG (rs763110), IL4 (rs2243250), IL4RA (rs1805010), and PPBP (rs352010) loci with pulmonary function variables were observed. The results of gene-gene interactions analysis showed distinctive patterns of association of inflammatory gene loci with COPD in groups stratified by smoking status. The combination of A allele of IL19 (rs2243193), C allele of IL4 (rs2243250), and T allele of PPBP (rs352010) was the main component of the majority of protective gene-gene combination associated with COPD in smokers. The highest risk of COPD was conferred by TT genotype of PPBP (rs352010) in combination with A allele of FAS (rs1800682). While in non-smokers, the most commonly featured was IL24 (rs291107) C allele in protective patterns and IL24 (rs291107) T allele in predisposing combinations. The highest risk of COPD in non-smokers was detected in a gene-gene combination consisting of A allele of IL12RB2 (rs3762317) together with G allele of IL12A (rs2243115), C allele of IL4 (rs2070874), and A allele of IL4RA (rs1805010).

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Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies

Cited by 19 publications

References 69 publications

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Association of IL-4 with pachychoroid neovasculopathy

Gene-gene and gene-environment interactions of the inflammatory gene variants in the development of chronic obstructive pulmonary disease

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