Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

Li, Hsing Hui; Cheng, He Hsiung; Sun, Kien-Wen; Wei, Chang-Ching; Li, Chien‐Feng; Chen, Wen Chung; Wu, Wen-Yih; Chang, Ming Shi

doi:10.1016/j.clim.2008.07.006

Cited by 39 publications

(23 citation statements)

References 24 publications

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“…Liang et al [26] reported that IL-22 can induce renal proximal tubule metabolic activity and associated an acute-phase response. Moreover, increased IL-22R expression in kidney has been found in New Zealand Black/White (NZB/W) mice, which develop a severe disease with a proliferative and sclerosing diffuse glomerulonephritis [27]. However, in the current study, it is very hard to show a causative role from this association study.…”

Section: Discussionmentioning

confidence: 63%

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

et al. 2011

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Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in peripheral blood mononuclear cells (PBMCs) from patients with SLE and their correlations with disease activity and clinical data. Five-color flow cytometry (FCM) was used to assess IL-22 production of CD4+/CD8+ T cells in PBMCs from 31 patients with SLE and 22 healthy control subjects, following stimulation ex vivo with phorbol 12-myristate 13-acetate and ionomycin for 4 h. Results showed that the percentages of IL-22-positive CD4+ T cells were increased in the PBMCs of patients with SLE compared with healthy control subjects, whereas there were no significant differences in the percentages of IL-22-positive CD8+ T cells. There was a strong positive correlation between the proportion of CD4+ T cells expressing IL-22 and SLEDAI score (r (s) = 0.65, P < 0.001). Furthermore, the frequencies of IL-22-positive CD4+ T cells were significantly higher in patients with SLE with nephritis than those without nephritis (Z = -2.72, P < 0.01). In conclusion, increased frequencies of IL-22-positive CD4+ T cells in patients with SLE and positive correlation with SLEDAI score and lupus nephritis suggest that this cytokine may be implicated in the pathogenesis of the disease.

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Section: Discussionmentioning

confidence: 63%

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

et al. 2011

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“…Additional studies are needed to clarify whether IL-20 plays a role in high-dose glucose-induced B7.1 expression in podocytes. Moreover, we have previously demonstrated 29 that IL-20 induced ROS production in mesangial cells. This finding suggested that IL-20 might cause podocyte apoptosis directly or indirectly by triggering mesangial cells to produce ROS in the microenvironment of the glomerulus.…”

Section: Discussionmentioning

confidence: 85%

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu

Sung

et al. 2017

Exp Mol Med

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Interleukin (IL)-20, a proinflammatory cytokine of the IL-10 family, is involved in acute and chronic renal failure. The aim of this study was to elucidate the role of IL-20 during diabetic nephropathy development. We found that IL-20 and its receptor IL-20R1 were upregulated in the kidneys of mice and rats with STZ-induced diabetes. In vitro, IL-20 induced MMP-9, MCP-1, TGF-β1 and VEGF expression in podocytes. IL-20 was upregulated by hydrogen peroxide, high-dose glucose and TGF-β1. In addition, IL-20 induced apoptosis in podocytes by activating caspase-8. In STZ-induced early diabetic nephropathy, IL-20R1-deficient mice had lower blood glucose and serum BUN levels and a smaller glomerular area than did wild-type controls. Anti-IL-20 monoclonal antibody (7E) treatment reduced blood glucose and the glomerular area and improved renal functions in mice in the early stage of STZ-induced diabetic nephropathy. ELISA showed that the serum IL-20 level was higher in patients with diabetes mellitus than in healthy controls. The findings of this study suggest that IL-20 induces cell apoptosis of podocytes and plays a role in the pathogenesis of early diabetic nephropathy.

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“…IL-20 was initially identified in a human keratinocyte library. 30 IL-20 is a proinflammatory cytokine, playing key roles in skin diseases, particularly psoriasis, 31 and has been implicated in lupus nephritis, arthritis, and atherosclerosis, [32][33][34] and treatment with an anti-IL-20 antibody produced a therapeutic benefit in arthritis. 35 IL-20 is expressed in a wide variety of cell types, particularly in lung and skin as well as bronchial epithelial cells.…”

Section: Il-20 and Receptors (Il-20ra Il-20rb)mentioning

confidence: 99%

Immunoregulatory Pathways Involved in Inflammatory Bowel Disease

Fonseca‐Camarillo

Yamamoto-Furusho

2015

Inflammatory Bowel Diseases

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Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Several immunoregulatory abnormalities have been reported in patients with IBD, including the ratio of proinflammatory (tumor necrosis factor alpha, IL-6, IL-1-β) to immunoregulatory cytokines (IL-10, TGF-β, IL-35) and selective activation of T-helper (Th) lymphocyte subsets (Th1, Th2, Th9, Th17, and regulatory T cells). The purpose of this review is to show the immunoregulatory pathways (regulatory cells and cytokines) involved in IBD published in recent years.

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Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

Cited by 39 publications

References 24 publications

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Immunoregulatory Pathways Involved in Inflammatory Bowel Disease

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