Immunoregulatory Pathways Involved in Inflammatory Bowel Disease

Fonseca‐Camarillo, Gabriela; Yamamoto-Furusho, Jesús K.

doi:10.1097/mib.0000000000000477

Cited by 91 publications

(61 citation statements)

References 55 publications

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“…The interactions between these and other cells present in the inflamed mucosa are mediated by various cytokines including both pro‐inflammatory and anti‐inflammatory cytokines. It is widely known that IL‐10 can antagonize Th1 cytokines and stabilize intestinal mucosal immune balance, serving as an important anti‐inflammatory cytokines which plays a protective role in the development of IBD . Our data demonstrated that IL‐10 was up‐regulated after the treatment of IL‐35 recombinant protein.…”

Section: Discussionmentioning

confidence: 52%

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

Wang

Mao

Zhang

et al. 2017

J Cellular Molecular Medi

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Interleukin-35 (IL-35), a member of the IL-12 family, functions as a new anti-inflammatory factor involved in arthritis, psoriasis, inflammatory bowel disease (IBD) and other immune diseases. Although IL-35 can significantly prevent the development of inflammation in many diseases, there have been no early studies accounting for the role of IL-35 recombinant protein in IBD and psoriasis. In this study, we assessed the therapeutic potential of IL-35 recombinant protein in three well-known mouse models: the dextransulfate sodium ( Further analysis demonstrated that IL-35 recombinant protein may regulate inflammation through promoting the secretion of IL-10 and inhibiting the expression of pro-inflammatory cytokines such as IL-6, TNF-a and IL-17 in acute colitis model. In addition, lower dose of IL-35 recombinant protein could achieve long-term treatment effects as TNF-a monoclonal antibody did in the psoriasis mouse. In summary, the remarkable therapeutic effects of IL-35 recombinant protein in acute colitis and psoriasis mouse models indicated that IL-35 recombinant protein had a variety of anti-inflammatory effects and was expected to become an effective candidate drug for the treatment of inflammatory diseases.

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Section: Discussionmentioning

confidence: 52%

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

Wang

Mao

Zhang

et al. 2017

J Cellular Molecular Medi

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“…ILVs are formed by invagination of the limiting membrane of late endosome, which are then termed MVBs. After intracellular trafficking, MVBs dock at and subsequently fuse with plasma membrane, leading to the excretion of ILVs as exosomes . MVBs could also be targeted to lysosomes for degradation of their internal vesicles.…”

Section: Exosome Characterization and Involvement In Intestinal Mucosmentioning

confidence: 99%

“…The crucial role of T regulatory (Treg) cells in maintaining immune tolerance and restraining immune response from excessive amplification is well accepted. Treg cells exert their suppressive function mainly through cytokines secretion, including IL‐10, TGF‐β and IL‐35, or in a cell contact‐dependent manner . Increased apoptosis and deficiency of Treg cells had been observed in active IBD patients, which could be reversed by anti‐TNFα treatment.…”

Section: Exosome‐mediated Immunosuppression Of Treg Cellsmentioning

confidence: 99%

Exosome in intestinal mucosal immunity

Lü

Ran

et al. 2016

J of Gastro and Hepatol

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Intercellular communication of immune cells is critical to elicit efficient inflammatory responses. In intestinal mucosa, imbalance in pro-inflammatory and anti-inflammatory mediators, especially cytokines and chemokines, characterizes the underlying immune mechanisms of inflammatory bowel disease. Exosomes, small membrane vesicles secreted into the extracellular environment, are emerging as another important intercellular messenger in immune responses. A major recent breakthrough in this field unveils the capacity of exosomes to mediate the functional transfer of genetic materials (mRNAs and miRNAs) between immune cells. RAB27A and RAB27B are two small GTPases involved in exosome secretion. With respect to intestinal mucosal immunity, increased number of RAB27A-positive immune cells and RAB27B-positive immune cells are demonstrated in the colonic mucosa of patients with active ulcerative colitis as compared with that of healthy controls. This indicates the important role of exosome-mediated immune responses in the pathogenesis of inflammatory bowel disease. Here, we will discuss the immune properties of exosomes and recent advances in their function with a special focus on intestinal mucosal immunity.

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“…The Th1 pattern inflammation of IBD is featured as over production of Th1 cytokines, such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-176. Some ulcerative colitis is featured as a Th2 pattern inflammation, in which high levels of Th2 cytokines play a major role in the inflammation of the colon mucosa7.…”

mentioning

confidence: 99%

Induction of colitis in mice with food allergen-specific immune response

Zeng

et al. 2016

Sci Rep

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The pathogenesis of intestinal chronic inflammation is unclear. Food allergy plays an important role in the induction of intestinal inflammation. This study aims to test a hypothesis that food allergy initiates colitis. In this study, BALB/c mice were sensitized to a common food allergen, ovalbumin (OVA) with cholera toxin (CT) as an adjuvant. The colon epithelial barrier function was assessed with Ussing chamber technique. Expression of T cell immunoglobulin mucin domain molecule-4 (TIM4) in dendritic cells was evaluated by flow cytometry, RT-PCR and Western blotting. The results showed that allergen-related colitis was induced in mice as shown by heavy infiltration of inflammatory cells in the colon mucosa, loss of body weight of mice, increases in myeloperoxidase, tumor necrosis factor-α, interleukin-4, OVA-specific IgE in the colon tissue. The colon epithelial barrier function was markedly compromised in colitis group mice, which was mimicked by exposure the colon mucosa to CT in Ussing chamber. High frequency of TIM4+ dendritic cells was detected in the colon mucosa of colitis mice. Exposure of dendritic cells to CT markedly increased the expression of TIM4. We conclude that IBD-like inflammation can be induced in the mouse colon by the food allergen-related immune response.

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Immunoregulatory Pathways Involved in Inflammatory Bowel Disease

Cited by 91 publications

References 55 publications

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

IL‐35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells

Exosome in intestinal mucosal immunity

Induction of colitis in mice with food allergen-specific immune response

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